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Low Grade Biliary Intraepithelial Neoplasia

MedGen UID:
1738000
•Concept ID:
C5419868
•
Neoplastic Process
Synonyms: Low Grade BilIN; Low-Grade Biliary Intraepithelial Neoplasia; Low-Grade BilIN

Definition

Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Biliary Intraepithelial Neoplasia

Professional guidelines

PubMed

Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article
Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.
Zen Y, Aishima S, Ajioka Y, Haratake J, Kage M, Kondo F, Nimura Y, Sakamoto M, Sasaki M, Shimamatsu K, Wakasa K, Park YN, Chen MF, Atomi Y, Nakanuma Y
Pathol Int 2005 Apr;55(4):180-8. doi: 10.1111/j.1440-1827.2005.01816.x. PMID: 15826244

Recent clinical studies

Etiology

Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder.
Böger C, Haag J, Egberts JH, Röcken C
Pathol Res Pract 2016 Jan;212(1):54-8. Epub 2015 Nov 14 doi: 10.1016/j.prp.2015.11.010. PMID: 26643927

Diagnosis

Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder.
Böger C, Haag J, Egberts JH, Röcken C
Pathol Res Pract 2016 Jan;212(1):54-8. Epub 2015 Nov 14 doi: 10.1016/j.prp.2015.11.010. PMID: 26643927

Prognosis

Dichotomy in intrahepatic cholangiocarcinomas based on histologic similarities to hilar cholangiocarcinomas.
Akita M, Fujikura K, Ajiki T, Fukumoto T, Otani K, Azuma T, Itoh T, Ku Y, Zen Y
Mod Pathol 2017 Jul;30(7):986-997. Epub 2017 Mar 24 doi: 10.1038/modpathol.2017.22. PMID: 28338651

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