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Colon Conventional Adenoma

MedGen UID:
1738948
Concept ID:
C5419784
Neoplastic Process

Definition

A benign, premalignant colon neoplasm composed of dysplastic epithelium. The descriptor ""conventional"" distinguishes this from lesions in the serrated pathway. (WHO 2019) [from NCI]

Professional guidelines

PubMed

Chu JE, Hamm J, Gentile L, Telford JJ, Schaeffer DF
J Clin Gastroenterol 2022 Mar 1;56(3):243-248. doi: 10.1097/MCG.0000000000001519. PMID: 33780220
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Lenz L, Martins B, Andrade de Paulo G, Kawaguti FS, Baba ER, Uemura RS, Gusmon CC, Geiger SN, Moura RN, Pennacchi C, Simas de Lima M, Safatle-Ribeiro AV, Hashimoto CL, Ribeiro U, Maluf-Filho F
Gastrointest Endosc 2023 Mar;97(3):549-558. Epub 2022 Oct 26 doi: 10.1016/j.gie.2022.10.033. PMID: 36309072
Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY
Clin Gastroenterol Hepatol 2023 Feb;21(2):337-346.e3. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.07.006. PMID: 35863686
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Diagnosis

Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY
Clin Gastroenterol Hepatol 2023 Feb;21(2):337-346.e3. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.07.006. PMID: 35863686
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS
Cell 2021 Dec 22;184(26):6262-6280.e26. Epub 2021 Dec 14 doi: 10.1016/j.cell.2021.11.031. PMID: 34910928Free PMC Article
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Therapy

Lenz L, Martins B, Andrade de Paulo G, Kawaguti FS, Baba ER, Uemura RS, Gusmon CC, Geiger SN, Moura RN, Pennacchi C, Simas de Lima M, Safatle-Ribeiro AV, Hashimoto CL, Ribeiro U, Maluf-Filho F
Gastrointest Endosc 2023 Mar;97(3):549-558. Epub 2022 Oct 26 doi: 10.1016/j.gie.2022.10.033. PMID: 36309072
Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY
Clin Gastroenterol Hepatol 2023 Feb;21(2):337-346.e3. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.07.006. PMID: 35863686
Bever AM, Hang D, He X, Joshi AD, Ding M, Wu K, Chan AT, Giovannucci EL, Song M
Dig Dis Sci 2022 Aug;67(8):4078-4085. Epub 2021 Aug 17 doi: 10.1007/s10620-021-07193-x. PMID: 34403030Free PMC Article
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article

Prognosis

Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Clinical prediction guides

Lenz L, Martins B, Andrade de Paulo G, Kawaguti FS, Baba ER, Uemura RS, Gusmon CC, Geiger SN, Moura RN, Pennacchi C, Simas de Lima M, Safatle-Ribeiro AV, Hashimoto CL, Ribeiro U, Maluf-Filho F
Gastrointest Endosc 2023 Mar;97(3):549-558. Epub 2022 Oct 26 doi: 10.1016/j.gie.2022.10.033. PMID: 36309072
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Bever AM, Hang D, He X, Joshi AD, Ding M, Wu K, Chan AT, Giovannucci EL, Song M
Dig Dis Sci 2022 Aug;67(8):4078-4085. Epub 2021 Aug 17 doi: 10.1007/s10620-021-07193-x. PMID: 34403030Free PMC Article
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Recent systematic reviews

Jung YS, Park JH, Park CH
Clin Gastroenterol Hepatol 2022 Jan;20(1):31-43.e1. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.051. PMID: 33007512
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Castaneda D, Popov VB, Verheyen E, Wander P, Gross SA
Gastrointest Endosc 2018 Aug;88(2):209-222.e11. Epub 2018 Apr 1 doi: 10.1016/j.gie.2018.03.022. PMID: 29614263
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article
Backes Y, Moss A, Reitsma JB, Siersema PD, Moons LM
Am J Gastroenterol 2017 Jan;112(1):54-64. Epub 2016 Sep 20 doi: 10.1038/ajg.2016.403. PMID: 27644737

Supplemental Content

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