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Benign neoplasm of large intestine

MedGen UID:
91125
•Concept ID:
C0347272
•
Neoplastic Process
Synonyms: Benign Colorectal Neoplasm; benign colorectal neoplasm; Benign Colorectal Neoplasms; benign colorectal neoplasms; Benign Colorectal Tumor; benign colorectal tumor; Benign Colorectal Tumors; benign colorectal tumors; benign colorectal tumour; benign colorectal tumours; Benign Large Bowel Neoplasm; benign large bowel neoplasm; Benign Large Bowel Tumor; benign large bowel tumor; benign large bowel tumour; Benign Large Intestine Neoplasm; benign large intestine neoplasm; Benign Large Intestine Tumor; benign large intestine tumor; benign large intestine tumour; Benign Neoplasm of Large Bowel; benign neoplasm of large bowel; Benign Neoplasm of Large Intestine; benign neoplasm of large intestine; Benign Neoplasm of the Large Bowel; benign neoplasm of the large bowel; Benign Neoplasm of the Large Intestine; benign neoplasm of the large intestine; Benign Tumor of Large Bowel; benign tumor of large bowel; Benign tumor of large intestine; Benign Tumor of Large Intestine; benign tumor of large intestine; Benign Tumor of the Large Bowel; benign tumor of the large bowel; Benign Tumor of the Large Intestine; benign tumor of the large intestine; benign tumour of large bowel; benign tumour of large intestine; benign tumour of the large bowel; benign tumour of the large intestine; Colorectal Neoplasms, Benign; colorectal neoplasms, benign; Colorectal Tumors, Benign; colorectal tumors, benign; large intestine benign neoplasm; Neoplasms, Colorectal, Benign; neoplasms, colorectal, benign; Tumors, Colorectal, Benign; tumors, colorectal, benign
SNOMED CT: Benign tumor of large intestine (92170008); Benign neoplasm of large intestine (92170008)
 
Monarch Initiative: MONDO:0021444

Definition

A neoplasm that arises from the colon or rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

Cystic lesions of the retrorectal space.
Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344

Diagnosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
GISTs of the large intestine: review of the literature.
Syllaios A, Schizas D, Davakis S, Koutras A, Vailas M, Machairas N, Mpaili E, Felekouras E
J BUON 2020 Jan-Feb;25(1):15-22. PMID: 32277610
What influences preneoplastic colorectal lesion recurrence?
De Maio G, Zama E, Rengucci C, Calistri D
Oncotarget 2017 Feb 14;8(7):12406-12416. doi: 10.18632/oncotarget.13628. PMID: 27902488Free PMC Article
Colonoscopy.
Kaminski MF, Zagorowicz E
Gastrointest Endosc 2014 Sep;80(3):400-3. doi: 10.1016/j.gie.2014.07.005. PMID: 25127944
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study.
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Definition of the Rectum: An International, Expert-based Delphi Consensus.
DʼSouza N, de Neree Tot Babberich MPM, d'Hoore A, Tiret E, Xynos E, Beets-Tan RGH, Nagtegaal ID, Blomqvist L, Holm T, Glimelius B, Lacy A, Cervantes A, Glynne-Jones R, West NP, Perez RO, Quadros C, Lee KY, Madiba TE, Wexner SD, Garcia-Aguilar J, Sahani D, Moran B, Tekkis P, Rutten HJ, Tanis PJ, Wiggers T, Brown G
Ann Surg 2019 Dec;270(6):955-959. doi: 10.1097/SLA.0000000000003251. PMID: 30973385
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Colorectal polyps in childhood.
Thakkar K, Fishman DS, Gilger MA
Curr Opin Pediatr 2012 Oct;24(5):632-7. doi: 10.1097/MOP.0b013e328357419f. PMID: 22890064

Prognosis

GISTs of the large intestine: review of the literature.
Syllaios A, Schizas D, Davakis S, Koutras A, Vailas M, Machairas N, Mpaili E, Felekouras E
J BUON 2020 Jan-Feb;25(1):15-22. PMID: 32277610
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Molecular pathology of colorectal cancer.
Bosman F, Yan P
Pol J Pathol 2014 Dec;65(4):257-66. doi: 10.5114/pjp.2014.48094. PMID: 25693079
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344
The epidemiology and pathogenesis of neoplasia in the small intestine.
Schottenfeld D, Beebe-Dimmer JL, Vigneau FD
Ann Epidemiol 2009 Jan;19(1):58-69. doi: 10.1016/j.annepidem.2008.10.004. PMID: 19064190Free PMC Article

Clinical prediction guides

AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review.
Murthy SK, Feuerstein JD, Nguyen GC, Velayos FS
Gastroenterology 2021 Sep;161(3):1043-1051.e4. doi: 10.1053/j.gastro.2021.05.063. PMID: 34416977
Attenuated adenomatous polyposis of the large bowel: Present and future.
Roncucci L, Pedroni M, Mariani F
World J Gastroenterol 2017 Jun 21;23(23):4135-4139. doi: 10.3748/wjg.v23.i23.4135. PMID: 28694653Free PMC Article
What influences preneoplastic colorectal lesion recurrence?
De Maio G, Zama E, Rengucci C, Calistri D
Oncotarget 2017 Feb 14;8(7):12406-12416. doi: 10.18632/oncotarget.13628. PMID: 27902488Free PMC Article
Molecular pathology of colorectal cancer.
Bosman F, Yan P
Pol J Pathol 2014 Dec;65(4):257-66. doi: 10.5114/pjp.2014.48094. PMID: 25693079
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma.
Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, Barnes R, Watson P, Allen-Vercoe E, Moore RA, Holt RA
Genome Res 2012 Feb;22(2):299-306. Epub 2011 Oct 18 doi: 10.1101/gr.126516.111. PMID: 22009989Free PMC Article

Recent systematic reviews

Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis.
Xiang J, Yan H, Li J, Wang X, Chen H, Zheng X
World J Surg Oncol 2019 Feb 13;17(1):31. doi: 10.1186/s12957-019-1573-0. PMID: 30760274Free PMC Article
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845
Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804

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