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Liver Neuroendocrine Tumor G1

MedGen UID:
1741024
•Concept ID:
C5419811
•
Neoplastic Process
Synonym: Hepatic Neuroendocrine Tumor G1

Definition

A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is less than 2 per 10 HPF. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Neuroendocrine Tumor G1

Professional guidelines

PubMed

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Diagnostic Management of Gastroenteropancreatic Neuroendocrine Neoplasms: Technique Optimization and Tips and Tricks for Radiologists.
Pellegrino F, Granata V, Fusco R, Grassi F, Tafuto S, Perrucci L, Tralli G, Scaglione M
Tomography 2023 Jan 27;9(1):217-246. doi: 10.3390/tomography9010018. PMID: 36828370Free PMC Article
Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms.
Janson ET, Sorbye H, Welin S, Federspiel B, Grønbæk H, Hellman P, Ladekarl M, Langer SW, Mortensen J, Schalin-Jäntti C, Sundin A, Sundlöv A, Thiis-Evensen E, Knigge U
Acta Oncol 2014 Oct;53(10):1284-97. Epub 2014 Aug 20 doi: 10.3109/0284186X.2014.941999. PMID: 25140861

Recent clinical studies

Etiology

Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor.
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
A Theranostic Cellulose Nanocrystal-Based Drug Delivery System with Enhanced Retention in Pulmonary Metastasis of Melanoma.
Imlimthan S, Khng YC, Keinänen O, Zhang W, Airaksinen AJ, Kostiainen MA, Zeglis BM, Santos HA, Sarparanta M
Small 2021 May;17(18):e2007705. Epub 2021 Mar 18 doi: 10.1002/smll.202007705. PMID: 33738957Free PMC Article
Nonconventional Doses of Somatostatin Analogs in Patients With Progressing Well-Differentiated Neuroendocrine Tumor.
Lamberti G, Faggiano A, Brighi N, Tafuto S, Ibrahim T, Brizzi MP, Pusceddu S, Albertelli M, Massironi S, Panzuto F, Badalamenti G, Riccardi F, Butturini G, Gelsomino F, De Divitiis C, Modica R, Bongiovanni A, La Salvia A, Torchio M, Colao A, Ferone D, Campana D
J Clin Endocrinol Metab 2020 Jan 1;105(1) doi: 10.1210/clinem/dgz035. PMID: 31545377
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Prognoses of GEP-NETS with undetermined malignant potentials of their primary sites.
Kudo A, Ban D, Akashi T, Kumagai J, Aihara A, Inokuchi M, Kojima K, Kawano T, Tanaka S, Arii S
Hepatogastroenterology 2012 Sep;59(118):1682-6. doi: 10.5754/hge12275. PMID: 22584425

Diagnosis

Improving outcomes in carcinoid heart disease - learning from a single centre.
Cope J, Maclean R, Hota S, Ramage JK, Mullholland N, Clement D, Brown S, Piper S, MaCarthy P, Wendler O, Srirajaskanthan R
Nucl Med Commun 2023 Nov 1;44(11):968-976. Epub 2023 Sep 4 doi: 10.1097/MNM.0000000000001749. PMID: 37661777
Diagnostic Management of Gastroenteropancreatic Neuroendocrine Neoplasms: Technique Optimization and Tips and Tricks for Radiologists.
Pellegrino F, Granata V, Fusco R, Grassi F, Tafuto S, Perrucci L, Tralli G, Scaglione M
Tomography 2023 Jan 27;9(1):217-246. doi: 10.3390/tomography9010018. PMID: 36828370Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms.
Janson ET, Sorbye H, Welin S, Federspiel B, Grønbæk H, Hellman P, Ladekarl M, Langer SW, Mortensen J, Schalin-Jäntti C, Sundin A, Sundlöv A, Thiis-Evensen E, Knigge U
Acta Oncol 2014 Oct;53(10):1284-97. Epub 2014 Aug 20 doi: 10.3109/0284186X.2014.941999. PMID: 25140861
A new simplified catalyzed signal amplification system for minimizing non-specific staining in tissues with supersensitive immunohistochemistry.
Hasui K, Murata F
Arch Histol Cytol 2005;68(1):1-17. doi: 10.1679/aohc.68.1. PMID: 15827374

Therapy

Improving outcomes in carcinoid heart disease - learning from a single centre.
Cope J, Maclean R, Hota S, Ramage JK, Mullholland N, Clement D, Brown S, Piper S, MaCarthy P, Wendler O, Srirajaskanthan R
Nucl Med Commun 2023 Nov 1;44(11):968-976. Epub 2023 Sep 4 doi: 10.1097/MNM.0000000000001749. PMID: 37661777
Transplant oncology: multivisceral transplantation for neuroendocrine tumor and liver metastasis.
Nagai S
Curr Opin Organ Transplant 2023 Jun 1;28(3):222-227. Epub 2023 Apr 10 doi: 10.1097/MOT.0000000000001063. PMID: 37040627
Mechanistic Target of Rapamycin (mTOR) Inhibitors.
Wang D, Eisen HJ
Handb Exp Pharmacol 2022;272:53-72. doi: 10.1007/164_2021_553. PMID: 35091825
Nonconventional Doses of Somatostatin Analogs in Patients With Progressing Well-Differentiated Neuroendocrine Tumor.
Lamberti G, Faggiano A, Brighi N, Tafuto S, Ibrahim T, Brizzi MP, Pusceddu S, Albertelli M, Massironi S, Panzuto F, Badalamenti G, Riccardi F, Butturini G, Gelsomino F, De Divitiis C, Modica R, Bongiovanni A, La Salvia A, Torchio M, Colao A, Ferone D, Campana D
J Clin Endocrinol Metab 2020 Jan 1;105(1) doi: 10.1210/clinem/dgz035. PMID: 31545377
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Prognosis

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Improving outcomes in carcinoid heart disease - learning from a single centre.
Cope J, Maclean R, Hota S, Ramage JK, Mullholland N, Clement D, Brown S, Piper S, MaCarthy P, Wendler O, Srirajaskanthan R
Nucl Med Commun 2023 Nov 1;44(11):968-976. Epub 2023 Sep 4 doi: 10.1097/MNM.0000000000001749. PMID: 37661777
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor.
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Nonconventional Doses of Somatostatin Analogs in Patients With Progressing Well-Differentiated Neuroendocrine Tumor.
Lamberti G, Faggiano A, Brighi N, Tafuto S, Ibrahim T, Brizzi MP, Pusceddu S, Albertelli M, Massironi S, Panzuto F, Badalamenti G, Riccardi F, Butturini G, Gelsomino F, De Divitiis C, Modica R, Bongiovanni A, La Salvia A, Torchio M, Colao A, Ferone D, Campana D
J Clin Endocrinol Metab 2020 Jan 1;105(1) doi: 10.1210/clinem/dgz035. PMID: 31545377
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

Clinical prediction guides

Therapeutic Challenges for Gastric Neuroendocrine Neoplasms: Take It or Leave It?
Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Improving outcomes in carcinoid heart disease - learning from a single centre.
Cope J, Maclean R, Hota S, Ramage JK, Mullholland N, Clement D, Brown S, Piper S, MaCarthy P, Wendler O, Srirajaskanthan R
Nucl Med Commun 2023 Nov 1;44(11):968-976. Epub 2023 Sep 4 doi: 10.1097/MNM.0000000000001749. PMID: 37661777
Liver Transplant for Patients With Neuroendocrine Tumor: A Report of 2 Exceptional Cases and Literature Review.
Moradi A, Lamsehchi N, Khaki S, Nasiri-Toosi M, Jafarian A
Exp Clin Transplant 2023 Jul;21(7):578-585. doi: 10.6002/ect.2023.0110. PMID: 37584538
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

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