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Eye Melanocytoma

MedGen UID:
1742372
•Concept ID:
C5421369
•
Neoplastic Process

Definition

A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea. [from NCI]

Professional guidelines

PubMed

Value of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control study.
Chen W, Yang W, Li D, Wang Z, Zhao Q, Li Y, Cui R, Shen L
Indian J Ophthalmol 2023 Mar;71(3):983-988. doi: 10.4103/ijo.IJO_1397_22. PMID: 36872722Free PMC Article
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Autofluorescence imaging in the differential diagnosis of optic disc melanocytoma.
Salvanos P, Utheim TP, Moe MC, Eide N, Bragadόttir R
Acta Ophthalmol 2015 Aug;93(5):476-480. Epub 2015 Apr 28 doi: 10.1111/aos.12725. PMID: 25923254

Recent clinical studies

Etiology

Primary Optic Disc Tumors - Case Series and Literature Overview.
Leclaire MD, Schatten H, Biermann J
Klin Monbl Augenheilkd 2022 Nov;239(11):1325-1336. Epub 2022 Aug 18 doi: 10.1055/a-1927-4111. PMID: 35981557
Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
Mirzayev I, Gündüz AK, Okçu Heper A
Eye (Lond) 2022 May;36(5):969-977. Epub 2021 May 3 doi: 10.1038/s41433-021-01545-7. PMID: 33941875Free PMC Article
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE
Nat Rev Dis Primers 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. PMID: 32273508
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055

Diagnosis

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE
Nat Rev Dis Primers 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. PMID: 32273508
BRCA1-associated protein (BAP1)-inactivated melanocytic tumors.
Zhang AJ, Rush PS, Tsao H, Duncan LM
J Cutan Pathol 2019 Dec;46(12):965-972. Epub 2019 Jul 11 doi: 10.1111/cup.13530. PMID: 31233225
Iris melanocytoma.
Radovanović AB, Krnjaja BD, Jaksić V
Srp Arh Celok Lek 2016 Jan-Feb;144(1-2):74-6. doi: 10.2298/sarh1602074b. PMID: 27276862
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063

Therapy

Optic disk melanocytoma associated with polypoidal choroidal vasculopathy lesions, after combination treatment of photodynamic therapy and intavitreal aflibercept (Eylea), a case report.
Rouvas A, Gouliopoulos NS, Moschos MM, Theodossiadis P
BMC Ophthalmol 2018 Oct 12;18(1):267. doi: 10.1186/s12886-018-0927-7. PMID: 30309335Free PMC Article
Pigment dispersion syndrome associated with optic nerve melanocytoma.
Asorey-García A, Méndez-Hernández CD, Santos-Bueso E, García-Feijoo J
Arch Soc Esp Oftalmol 2015 Oct;90(10):484-6. Epub 2015 May 23 doi: 10.1016/j.oftal.2015.04.005. PMID: 26008928
Choroidal neovascularization of optic disk melanocytoma treated with bevacizumab.
Kamisasanuk T, Uchino E, Sakamoto T
Eur J Ophthalmol 2012 May-Jun;22(3):503-5. doi: 10.5301/ejo.5000060. PMID: 21959681
Aggressive management of orbital meningeal melanocytoma.
de Tella OI Jr, Agner C, Aguiar PH, Herculano MA, Prandini MN, Stavile JN
Acta Neurochir (Wien) 2003 Dec;145(12):1121-6. Epub 2003 Oct 13 doi: 10.1007/s00701-003-0121-3. PMID: 14663571
Clinical evaluation of posterior embryotoxon in one institution.
Ozeki H, Shirai S, Majima A, Sano M, Ikeda K
Jpn J Ophthalmol 1997 Nov-Dec;41(6):422-5. doi: 10.1016/s0021-5155(97)00080-4. PMID: 9509311

Prognosis

Primary Optic Disc Tumors - Case Series and Literature Overview.
Leclaire MD, Schatten H, Biermann J
Klin Monbl Augenheilkd 2022 Nov;239(11):1325-1336. Epub 2022 Aug 18 doi: 10.1055/a-1927-4111. PMID: 35981557
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Iris melanocytoma and secondary glaucoma.
Xavier C, Hipolito-Fernandes D, Cardigos J, Magriço A
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-237269. PMID: 33318246Free PMC Article
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE
Nat Rev Dis Primers 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. PMID: 32273508
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055

Clinical prediction guides

Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
Mirzayev I, Gündüz AK, Okçu Heper A
Eye (Lond) 2022 May;36(5):969-977. Epub 2021 May 3 doi: 10.1038/s41433-021-01545-7. PMID: 33941875Free PMC Article
Clinicopathologic analysis of 32 ciliary body tumors.
Goto H, Yamakawa N, Tsubota K, Umazume K, Usui Y
Jpn J Ophthalmol 2021 Mar;65(2):237-249. Epub 2021 Feb 19 doi: 10.1007/s10384-021-00814-y. PMID: 33606097
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Iris melanocytoma: clinical features and natural course in 47 cases.
Demirci H, Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2005 Mar;139(3):468-75. doi: 10.1016/j.ajo.2004.10.008. PMID: 15767055
Melanocytomas of the optic nerve and uvea.
Khadem JJ, Weiter JJ
Int Ophthalmol Clin 1997 Fall;37(4):149-58. doi: 10.1097/00004397-199703740-00013. PMID: 9429938

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