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Unresectable Thyroid Gland Oncocytic Carcinoma

MedGen UID:
1742418
•Concept ID:
C5420862
•
Neoplastic Process
Synonyms: Unresectable Thyroid Gland Hurthle Cell Carcinoma; Unresectable Thyroid Gland Oncocytic (Hurthle Cell) Carcinoma

Definition

Thyroid gland oncocytic carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Thyroid Gland Oncocytic Carcinoma

Professional guidelines

PubMed

Radioiodine and radiotherapy in the management of thyroid cancers.
Simpson WJ
Otolaryngol Clin North Am 1990 Jun;23(3):509-21. PMID: 1694984

Recent clinical studies

Etiology

Lenvatinib-induced thyroid abnormalities in unresectable hepatocellular carcinoma.
Koizumi Y, Hirooka M, Hiraoka A, Ochi H, Tanaka T, Yukimoto A, Imai Y, Watanabe T, Yoshida O, Miyake T, Matsuura B, Michitaka K, Joko K, Abe M, Hiasa Y
Endocr J 2019 Sep 28;66(9):787-792. Epub 2019 May 30 doi: 10.1507/endocrj.EJ19-0140. PMID: 31142692
Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation.
Faure Conter C, Fresneau B, Thebaud E, Bertrand A, Dijoud F, Rome A, Dumesnil C, Castex MP, Ghanem A, Orbach D
J Pediatr Hematol Oncol 2017 Jul;39(5):388-394. doi: 10.1097/MPH.0000000000000823. PMID: 28375941
Surgical management of metastases to the thyroid gland.
Nixon IJ, Whitcher M, Glick J, Palmer FL, Shaha AR, Shah JP, Patel SG, Ganly I
Ann Surg Oncol 2011 Mar;18(3):800-4. Epub 2010 Nov 3 doi: 10.1245/s10434-010-1408-2. PMID: 21046263
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908

Diagnosis

Potential role of sorafenib as neoadjuvant therapy in unresectable papillary thyroid cancer.
Danilovic DLS, Castro G Jr, Roitberg FSR, Vanderlei FAB, Bonani FA, Freitas RMC, Coura-Filho GB, Camargo RY, Kulcsar MA, Marui S, Hoff AO
Arch Endocrinol Metab 2018 Jun;62(3):370-375. Epub 2018 May 17 doi: 10.20945/2359-3997000000046. PMID: 29791660Free PMC Article
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation.
Faure Conter C, Fresneau B, Thebaud E, Bertrand A, Dijoud F, Rome A, Dumesnil C, Castex MP, Ghanem A, Orbach D
J Pediatr Hematol Oncol 2017 Jul;39(5):388-394. doi: 10.1097/MPH.0000000000000823. PMID: 28375941
Mixed squamous cell carcinoma and follicular carcinoma of the thyroid gland.
Mercante G, Marchesi A, Covello R, Dainese L, Spriano G
Auris Nasus Larynx 2012 Jun;39(3):310-3. Epub 2011 Sep 8 doi: 10.1016/j.anl.2011.07.003. PMID: 21855238
Presentation of a medullary endocrine neoplasia 2A kindred with Cushing's syndrome.
Zaydfudim V, Stover DG, Caro SW, Phay JE
Am Surg 2008 Jul;74(7):659-61. PMID: 18646485
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908

Therapy

Lenvatinib-induced thyroid abnormalities in unresectable hepatocellular carcinoma.
Koizumi Y, Hirooka M, Hiraoka A, Ochi H, Tanaka T, Yukimoto A, Imai Y, Watanabe T, Yoshida O, Miyake T, Matsuura B, Michitaka K, Joko K, Abe M, Hiasa Y
Endocr J 2019 Sep 28;66(9):787-792. Epub 2019 May 30 doi: 10.1507/endocrj.EJ19-0140. PMID: 31142692
Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article
Potential role of sorafenib as neoadjuvant therapy in unresectable papillary thyroid cancer.
Danilovic DLS, Castro G Jr, Roitberg FSR, Vanderlei FAB, Bonani FA, Freitas RMC, Coura-Filho GB, Camargo RY, Kulcsar MA, Marui S, Hoff AO
Arch Endocrinol Metab 2018 Jun;62(3):370-375. Epub 2018 May 17 doi: 10.20945/2359-3997000000046. PMID: 29791660Free PMC Article
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908
Radioiodine and radiotherapy in the management of thyroid cancers.
Simpson WJ
Otolaryngol Clin North Am 1990 Jun;23(3):509-21. PMID: 1694984

Prognosis

Lenvatinib-induced thyroid abnormalities in unresectable hepatocellular carcinoma.
Koizumi Y, Hirooka M, Hiraoka A, Ochi H, Tanaka T, Yukimoto A, Imai Y, Watanabe T, Yoshida O, Miyake T, Matsuura B, Michitaka K, Joko K, Abe M, Hiasa Y
Endocr J 2019 Sep 28;66(9):787-792. Epub 2019 May 30 doi: 10.1507/endocrj.EJ19-0140. PMID: 31142692
Surgical management of metastases to the thyroid gland.
Nixon IJ, Whitcher M, Glick J, Palmer FL, Shaha AR, Shah JP, Patel SG, Ganly I
Ann Surg Oncol 2011 Mar;18(3):800-4. Epub 2010 Nov 3 doi: 10.1245/s10434-010-1408-2. PMID: 21046263
Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy.
Nar Demirer A, Ayturk S, Tutuncu NB, Gursoy A, Pak Y, Demirag NG
Exp Clin Endocrinol Diabetes 2009 Apr;117(4):155-8. Epub 2008 Jun 17 doi: 10.1055/s-2008-1078743. PMID: 18561094
Multiple endocrine neoplasia type 2.
Gertner ME, Kebebew E
Curr Treat Options Oncol 2004 Aug;5(4):315-25. doi: 10.1007/s11864-004-0022-6. PMID: 15233908
Radioiodine and radiotherapy in the management of thyroid cancers.
Simpson WJ
Otolaryngol Clin North Am 1990 Jun;23(3):509-21. PMID: 1694984

Clinical prediction guides

Lenvatinib-induced thyroid abnormalities in unresectable hepatocellular carcinoma.
Koizumi Y, Hirooka M, Hiraoka A, Ochi H, Tanaka T, Yukimoto A, Imai Y, Watanabe T, Yoshida O, Miyake T, Matsuura B, Michitaka K, Joko K, Abe M, Hiasa Y
Endocr J 2019 Sep 28;66(9):787-792. Epub 2019 May 30 doi: 10.1507/endocrj.EJ19-0140. PMID: 31142692
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation.
Faure Conter C, Fresneau B, Thebaud E, Bertrand A, Dijoud F, Rome A, Dumesnil C, Castex MP, Ghanem A, Orbach D
J Pediatr Hematol Oncol 2017 Jul;39(5):388-394. doi: 10.1097/MPH.0000000000000823. PMID: 28375941
Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy.
Nar Demirer A, Ayturk S, Tutuncu NB, Gursoy A, Pak Y, Demirag NG
Exp Clin Endocrinol Diabetes 2009 Apr;117(4):155-8. Epub 2008 Jun 17 doi: 10.1055/s-2008-1078743. PMID: 18561094
Phase I clinical trial of targeted therapy using 131I-Hepama-1 mAb in patients with hepatocellular carcinoma.
Chen S, Li B, Xie H, Xu L, Niu G, Fan K, Fan Q
Cancer Biother Radiopharm 2004 Oct;19(5):589-600. doi: 10.1089/cbr.2004.19.589. PMID: 15650451

Recent systematic reviews

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article

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