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Follicular thyroid carcinoma(NMTC2)

MedGen UID:
64630
Concept ID:
C0206682
Neoplastic Process
Synonyms: NMTC2; Thyroid cancer, follicular; Thyroid gland follicular carcinoma
SNOMED CT: Follicular adenocarcinoma - well differentiated (28173006); Follicular carcinoma - well differentiated (28173006); FTC - follicular thyroid carcinoma (255028004); Follicular thyroid carcinoma (255028004); Follicular adenocarcinoma, well differentiated (28173006); Follicular carcinoma, well differentiated (28173006); Follicular adenocarcinoma (5257006); Follicular carcinoma (5257006)
 
HPO: HP:0006731
Monarch Initiative: MONDO:0005034
OMIM®: 605391

Definition

The presence of an follicular adenocarcinoma of the thyroid gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFollicular thyroid carcinoma

Conditions with this feature

Thyroid cancer, nonmedullary, 2
MedGen UID:
904175
Concept ID:
C4225426
Neoplastic Process
Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550).

Professional guidelines

PubMed

Bolin J
J Nucl Med Technol 2021 Sep;49(3):199-208. Epub 2021 Jul 9 doi: 10.2967/jnmt.120.257105. PMID: 34244225
Jung CK, Kim Y, Jeon S, Jo K, Lee S, Bae JS
Hum Pathol 2018 Nov;81:9-17. Epub 2018 May 1 doi: 10.1016/j.humpath.2018.04.018. PMID: 29723601
Ríos A, Rodríguez JM, Parrilla P
Cir Esp 2015 Dec;93(10):611-8. Epub 2015 Sep 26 doi: 10.1016/j.ciresp.2015.06.004. PMID: 26412746

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024

UK NICE Guideline NG230, Thyroid cancer: assessment and management

Recent clinical studies

Etiology

Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Kuo TC, Wu MH, Chen KY, Hsieh MS, Chen A, Chen CN
Asian J Surg 2020 Jan;43(1):339-346. Epub 2019 Jun 8 doi: 10.1016/j.asjsur.2019.04.016. PMID: 31182260
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Bauer AJ
Endocr Dev 2014;26:183-201. Epub 2014 Aug 29 doi: 10.1159/000363164. PMID: 25231453

Diagnosis

Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Dickerson T, Poche W, Meaux T
Skinmed 2021;19(1):69-71. Epub 2021 Feb 1 PMID: 33658120
Yakushina VD, Lerner LV, Lavrov AV
Thyroid 2018 Feb;28(2):158-167. doi: 10.1089/thy.2017.0318. PMID: 29281951
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Therapy

Schmidt M, Görges R, Drzezga A, Dietlein M
J Nucl Med 2018 Aug;59(8):1195-1201. Epub 2018 May 10 doi: 10.2967/jnumed.117.191338. PMID: 29748234
Sturniolo G, Violi MA, Galletti B, Baldari S, Campennì A, Vermiglio F, Moleti M
Endocrine 2016 Jan;51(1):189-98. Epub 2015 May 19 doi: 10.1007/s12020-015-0593-y. PMID: 25987346
Haigh PI
Curr Treat Options Oncol 2002 Aug;3(4):349-54. doi: 10.1007/s11864-002-0034-z. PMID: 12074771
Schlumberger MJ, Torlantano M
Baillieres Best Pract Res Clin Endocrinol Metab 2000 Dec;14(4):601-13. doi: 10.1053/beem.2000.0105. PMID: 11289737
Schlumberger MJ
N Engl J Med 1998 Jan 29;338(5):297-306. doi: 10.1056/NEJM199801293380506. PMID: 9445411

Prognosis

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Yakushina VD, Lerner LV, Lavrov AV
Thyroid 2018 Feb;28(2):158-167. doi: 10.1089/thy.2017.0318. PMID: 29281951
Baloch ZW, LiVolsi VA
Histopathology 2018 Jan;72(1):40-52. doi: 10.1111/his.13348. PMID: 29239042
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Clinical prediction guides

Díaz R, Domínguez JM, Tala H, Olmos R, Pineda P, Olivarí D, Jiménez M, Mimica X, Lanas A, Ocares G, Sapunar J
Arch Endocrinol Metab 2023 Mar 30;67(3):348-354. Epub 2023 Jan 17 doi: 10.20945/2359-3997000000580. PMID: 36651709Free PMC Article
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Yu Q, Liu K, Xie C, Ma D, Wu Y, Jiang H, Dai W
Clin Endocrinol (Oxf) 2019 Aug;91(2):348-355. Epub 2019 May 9 doi: 10.1111/cen.14002. PMID: 31050007
Sturniolo G, Violi MA, Galletti B, Baldari S, Campennì A, Vermiglio F, Moleti M
Endocrine 2016 Jan;51(1):189-98. Epub 2015 May 19 doi: 10.1007/s12020-015-0593-y. PMID: 25987346
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
San Juan MD, Paz-Pacheco E
J ASEAN Fed Endocr Soc 2023;38(1):100-107. Epub 2023 Mar 2 doi: 10.15605/jafes.038.01.14. PMID: 37252408Free PMC Article
Varadarajan VV, Pace EK, Patel V, Sawhney R, Amdur RJ, Dziegielewski PT
BMC Cancer 2017 Mar 28;17(1):225. doi: 10.1186/s12885-017-3199-3. PMID: 28351395Free PMC Article
Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H
Head Neck 2016 Apr;38 Suppl 1:E2297-305. Epub 2015 Sep 3 doi: 10.1002/hed.24218. PMID: 26335228

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024
    • NICE, 2022
      UK NICE Guideline NG230, Thyroid cancer: assessment and management

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