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Head and Neck Melanocytic Neoplasm

MedGen UID:
1749486
•Concept ID:
C5420234
•
Neoplastic Process

Definition

A melanocytic neoplasm that arises from the skin or mucosal sites in the head and neck region. [from NCI]

Professional guidelines

PubMed

Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Lentigo maligna: diagnosis and treatment.
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288

Recent clinical studies

Etiology

Implementing structured pathology reporting protocol for non-melanocytic skin cancers: practical considerations.
Gupta R, Selinger CI, Ashford B, Chua MST, Clark JR, Damian DL, Jackett LA, James C, Johnson S, Ladwa R, Lambie D, McKenzie C, Tan ST, Scolyer RA
Pathology 2023 Oct;55(6):743-759. Epub 2023 Jul 28 doi: 10.1016/j.pathol.2023.07.003. PMID: 37573165
Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
PRAME Expression in Mucosal Melanoma of the Head and Neck Region.
Ricci C, Altavilla MV, Corti B, Pasquini E, Presutti L, Baietti AM, Amorosa L, Balbi T, Baldovini C, Ambrosi F, Grillini M, D'Errico A, Fiorentino M, Foschini MP
Am J Surg Pathol 2023 May 1;47(5):599-610. Epub 2023 Mar 13 doi: 10.1097/PAS.0000000000002032. PMID: 36912431Free PMC Article
Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.
Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM, Mosaieby E, Slouka D, Ferlito A
Adv Anat Pathol 2022 Jul 1;29(4):217-226. Epub 2022 Mar 7 doi: 10.1097/PAP.0000000000000339. PMID: 35249992
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article

Diagnosis

The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base.
Thompson LDR, Bishop JA
Head Neck Pathol 2022 Mar;16(1):1-18. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01406-5. PMID: 35312976Free PMC Article
Lentigo maligna: diagnosis and treatment.
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
The deep penetrating nevus.
Strazzula L, Senna MM, Yasuda M, Belazarian L
J Am Acad Dermatol 2014 Dec;71(6):1234-40. Epub 2014 Aug 28 doi: 10.1016/j.jaad.2014.07.026. PMID: 25175710
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245

Therapy

Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
Kanazawa K, Kishimoto K, Nomura M, Kurosawa K, Kato H, Inoue Y, Miura K, Fukui K, Yamashita Y, Sato I, Tsuji H, Watanabe T, Tanaka T, Yasuda J, Tanuma N, Shima H
Cancer Sci 2021 Jun;112(6):2233-2244. Epub 2021 Apr 10 doi: 10.1111/cas.14895. PMID: 33743547Free PMC Article
A systematic review of non-surgical treatments for lentigo maligna.
Read T, Noonan C, David M, Wagels M, Foote M, Schaider H, Soyer HP, Smithers BM
J Eur Acad Dermatol Venereol 2016 May;30(5):748-53. Epub 2015 Aug 24 doi: 10.1111/jdv.13252. PMID: 26299846
Src family kinases and paclitaxel sensitivity.
Le XF, Bast RC Jr
Cancer Biol Ther 2011 Aug 15;12(4):260-9. doi: 10.4161/cbt.12.4.16430. PMID: 21646863Free PMC Article
Lentigo maligna : prognosis and treatment options.
Stevenson O, Ahmed I
Am J Clin Dermatol 2005;6(3):151-64. doi: 10.2165/00128071-200506030-00002. PMID: 15943492
Management of lentigo maligna and lentigo maligna melanoma: seminars in surgical oncology.
Arlette JP, Trotter MJ, Trotter T, Temple CL
J Surg Oncol 2004 Jul 1;86(4):179-86. doi: 10.1002/jso.20081. PMID: 15221924

Prognosis

Epidemiology, staging and management of mucosal melanoma of the head and neck: a narrative review.
Jeong YJ, Thompson JF, Ch'ng S
Chin Clin Oncol 2023 Jun;12(3):28. doi: 10.21037/cco-23-16. PMID: 37417292
Human melanocyte development and melanoma dedifferentiation at single-cell resolution.
Belote RL, Le D, Maynard A, Lang UE, Sinclair A, Lohman BK, Planells-Palop V, Baskin L, Tward AD, Darmanis S, Judson-Torres RL
Nat Cell Biol 2021 Sep;23(9):1035-1047. Epub 2021 Sep 2 doi: 10.1038/s41556-021-00740-8. PMID: 34475532
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245
Lentigo maligna.
Smalberger GJ, Siegel DM, Khachemoune A
Dermatol Ther 2008 Nov-Dec;21(6):439-46. doi: 10.1111/j.1529-8019.2008.00244.x. PMID: 19076621
Desmoplastic melanoma.
Batsakis JG, Raymond AK
Ann Otol Rhinol Laryngol 1994 Jan;103(1):77-9. doi: 10.1177/000348949410300115. PMID: 8291864

Clinical prediction guides

PRAME Expression in Mucosal Melanoma of the Head and Neck Region.
Ricci C, Altavilla MV, Corti B, Pasquini E, Presutti L, Baietti AM, Amorosa L, Balbi T, Baldovini C, Ambrosi F, Grillini M, D'Errico A, Fiorentino M, Foschini MP
Am J Surg Pathol 2023 May 1;47(5):599-610. Epub 2023 Mar 13 doi: 10.1097/PAS.0000000000002032. PMID: 36912431Free PMC Article
Human melanocyte development and melanoma dedifferentiation at single-cell resolution.
Belote RL, Le D, Maynard A, Lang UE, Sinclair A, Lohman BK, Planells-Palop V, Baskin L, Tward AD, Darmanis S, Judson-Torres RL
Nat Cell Biol 2021 Sep;23(9):1035-1047. Epub 2021 Sep 2 doi: 10.1038/s41556-021-00740-8. PMID: 34475532
Malignant Melanoma Cells and Hair Follicles.
Dika E, Veronesi G, Misciali C, Corti B, Dika I, Riefolo M, Scarfì F, Lambertini M, Patrizi A
Am J Clin Pathol 2019 Jun 5;152(1):109-114. doi: 10.1093/ajcp/aqz029. PMID: 31165166
Dermatopathology updates on melanocytic lesions.
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049
Src family kinases and paclitaxel sensitivity.
Le XF, Bast RC Jr
Cancer Biol Ther 2011 Aug 15;12(4):260-9. doi: 10.4161/cbt.12.4.16430. PMID: 21646863Free PMC Article

Recent systematic reviews

Vitamin D Receptor Polymorphisms and Cancer.
Gnagnarella P, Raimondi S, Aristarco V, Johansson HA, Bellerba F, Corso F, Gandini S
Adv Exp Med Biol 2020;1268:53-114. doi: 10.1007/978-3-030-46227-7_4. PMID: 32918214
Malignant peripheral nerve sheath tumors of the eighth cranial nerve arising without prior irradiation.
Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487
A systematic review of non-surgical treatments for lentigo maligna.
Read T, Noonan C, David M, Wagels M, Foote M, Schaider H, Soyer HP, Smithers BM
J Eur Acad Dermatol Venereol 2016 May;30(5):748-53. Epub 2015 Aug 24 doi: 10.1111/jdv.13252. PMID: 26299846
Divided nevus of the eyelid: review of embryology, pathology and treatment.
Desai SC, Walen S, Holds JB, Branham G
Am J Otolaryngol 2013 May-Jun;34(3):223-9. Epub 2013 Feb 4 doi: 10.1016/j.amjoto.2013.01.004. PMID: 23380310
Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case.
Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Aug;102(2):204-16. Epub 2006 Jun 8 doi: 10.1016/j.tripleo.2005.08.010. PMID: 16876064

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