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Advanced Differentiated Thyroid Gland Carcinoma

MedGen UID:
1756186
•Concept ID:
C5420499
•
Neoplastic Process

Definition

Differentiated thyroid gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Differentiated Thyroid Gland Carcinoma

Professional guidelines

PubMed

Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
Updates on the Management of Thyroid Cancer.
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent clinical studies

Etiology

Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
Thyroid cancer, recent advances in diagnosis and therapy.
Nabhan F, Dedhia PH, Ringel MD
Int J Cancer 2021 Sep 1;149(5):984-992. Epub 2021 May 29 doi: 10.1002/ijc.33690. PMID: 34013533
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Updates on the Management of Thyroid Cancer.
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Diagnosis

Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
Thyroid cancer, recent advances in diagnosis and therapy.
Nabhan F, Dedhia PH, Ringel MD
Int J Cancer 2021 Sep 1;149(5):984-992. Epub 2021 May 29 doi: 10.1002/ijc.33690. PMID: 34013533
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Updates on the Management of Thyroid Cancer.
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Therapy

Current Guidelines for Management of Medullary Thyroid Carcinoma.
Kim M, Kim BH
Endocrinol Metab (Seoul) 2021 Jun;36(3):514-524. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.1082. PMID: 34154310Free PMC Article
Current practice in patients with differentiated thyroid cancer.
Schlumberger M, Leboulleux S
Nat Rev Endocrinol 2021 Mar;17(3):176-188. Epub 2020 Dec 18 doi: 10.1038/s41574-020-00448-z. PMID: 33339988
Updates on the Management of Thyroid Cancer.
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy.
Liu J, Liu Y, Lin Y, Liang J
Endocrinol Metab (Seoul) 2019 Sep;34(3):215-225. doi: 10.3803/EnM.2019.34.3.215. PMID: 31565873Free PMC Article
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial.
Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, Sherman SI, Smit JW, Chung J, Kappeler C, Peña C, Molnár I, Schlumberger MJ; DECISION investigators
Lancet 2014 Jul 26;384(9940):319-28. Epub 2014 Apr 24 doi: 10.1016/S0140-6736(14)60421-9. PMID: 24768112Free PMC Article

Prognosis

Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Updates on the Management of Thyroid Cancer.
Araque KA, Gubbi S, Klubo-Gwiezdzinska J
Horm Metab Res 2020 Aug;52(8):562-577. Epub 2020 Feb 10 doi: 10.1055/a-1089-7870. PMID: 32040962Free PMC Article
Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.
Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA
J Clin Invest 2016 Mar 1;126(3):1052-66. Epub 2016 Feb 15 doi: 10.1172/JCI85271. PMID: 26878173Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Clinical prediction guides

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.
Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA
J Clin Invest 2016 Mar 1;126(3):1052-66. Epub 2016 Feb 15 doi: 10.1172/JCI85271. PMID: 26878173Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article
Thyroid Gland Malignancies.
Cabanillas ME, Dadu R, Hu MI, Lu C, Gunn GB, Grubbs EG, Lai SY, Williams MD
Hematol Oncol Clin North Am 2015 Dec;29(6):1123-43. doi: 10.1016/j.hoc.2015.07.011. PMID: 26568552

Recent systematic reviews

Microbiota and Thyroid Disease: An Updated Systematic Review.
Stramazzo I, Capriello S, Filardo S, Centanni M, Virili C
Adv Exp Med Biol 2023;1370:125-144. doi: 10.1007/5584_2023_770. PMID: 36971966
The Role of postoperative external beam radiotherapy for differentiated thyroid carcinoma: A Systematic review and meta-analysis.
Jacomina LE, Jacinto JKM, Co LBA, Yu KKL, Agas RAF, Co JL, Mejia MBA
Head Neck 2020 Aug;42(8):2181-2193. Epub 2020 Mar 4 doi: 10.1002/hed.26133. PMID: 32129545
Lenvatinib for the treatment of radioiodine-refractory differentiated thyroid carcinoma: a systematic review and indirect comparison with sorafenib.
Kawalec P, Malinowska-Lipień I, Brzostek T, Kózka M
Expert Rev Anticancer Ther 2016 Dec;16(12):1303-1309. Epub 2016 Oct 28 doi: 10.1080/14737140.2016.1247697. PMID: 27734713
Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review.
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T
Endocr Relat Cancer 2016 Feb;23(2):R71-84. doi: 10.1530/ERC-15-0194. PMID: 27064164
Pharmacotherapy options for advanced thyroid cancer: a systematic review.
Lerch C, Richter B
Drugs 2012 Jan 1;72(1):67-85. doi: 10.2165/11594890-000000000-00000. PMID: 22191796

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