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Advanced Adenocarcinoma

MedGen UID:
1693607
•Concept ID:
C5204526
•
Neoplastic Process

Definition

An adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adenocarcinoma

Professional guidelines

PubMed

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Recent clinical studies

Etiology

Efficacy of ramucirumab combination chemotherapy as second-line treatment in patients with advanced adenocarcinoma of the stomach or gastroesophageal junction after exposure to checkpoint inhibitors and chemotherapy as first-line therapy.
Masetti M, Al-Batran SE, Goetze TO, Thuss-Patience P, Knorrenschild JR, Goekkurt E, Folprecht G, Ettrich TJ, Lindig U, Luley KB, Pink D, Dechow T, Sookthai D, Junge S, Loose M, Pauligk C, Lorenzen S
Int J Cancer 2024 Jun 15;154(12):2142-2150. Epub 2024 Mar 6 doi: 10.1002/ijc.34894. PMID: 38447003
Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Surgical approach to advanced Siewert II cancer: beyond the borders? The West Side.
Hölscher AH, Bollschweiler E, Fetzner UK, Babic B
Updates Surg 2023 Feb;75(2):329-333. Epub 2022 Aug 24 doi: 10.1007/s13304-022-01363-w. PMID: 36001282
Androgen deprivation therapy impact on quality of life and cardiovascular health, monitoring therapeutic replacement.
Trost LW, Serefoglu E, Gokce A, Linder BJ, Sartor AO, Hellstrom WJ
J Sex Med 2013 Feb;10 Suppl 1:84-101. doi: 10.1111/jsm.12036. PMID: 23387914
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Diagnosis

Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Biomarkers for Selection of Therapy for Adenocarcinoma of the Lung.
Bernicker EH, Miller RA, Cagle PT
J Oncol Pract 2017 Apr;13(4):221-227. doi: 10.1200/JOP.2016.019182. PMID: 28399384
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Pathology of lung cancer.
Travis WD
Clin Chest Med 2011 Dec;32(4):669-92. doi: 10.1016/j.ccm.2011.08.005. PMID: 22054879
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Therapy

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study.
Türeci O, Sahin U, Schulze-Bergkamen H, Zvirbule Z, Lordick F, Koeberle D, Thuss-Patience P, Ettrich T, Arnold D, Bassermann F, Al-Batran SE, Wiechen K, Dhaene K, Maurus D, Gold M, Huber C, Krivoshik A, Arozullah A, Park JW, Schuler M
Ann Oncol 2019 Sep 1;30(9):1487-1495. doi: 10.1093/annonc/mdz199. PMID: 31240302Free PMC Article
Antiangiogenic Therapy in Gastroesophageal Cancer.
Jin Z, Yoon HH
Hematol Oncol Clin North Am 2017 Jun;31(3):499-510. Epub 2017 Mar 22 doi: 10.1016/j.hoc.2017.01.008. PMID: 28501090
Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie.
Al-Batran SE, Hartmann JT, Probst S, Schmalenberg H, Hollerbach S, Hofheinz R, Rethwisch V, Seipelt G, Homann N, Wilhelm G, Schuch G, Stoehlmacher J, Derigs HG, Hegewisch-Becker S, Grossmann J, Pauligk C, Atmaca A, Bokemeyer C, Knuth A, Jäger E; Arbeitsgemeinschaft Internistische Onkologie
J Clin Oncol 2008 Mar 20;26(9):1435-42. doi: 10.1200/JCO.2007.13.9378. PMID: 18349393

Prognosis

Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Biomarkers for Selection of Therapy for Adenocarcinoma of the Lung.
Bernicker EH, Miller RA, Cagle PT
J Oncol Pract 2017 Apr;13(4):221-227. doi: 10.1200/JOP.2016.019182. PMID: 28399384
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Clinical prediction guides

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Biomarkers for Selection of Therapy for Adenocarcinoma of the Lung.
Bernicker EH, Miller RA, Cagle PT
J Oncol Pract 2017 Apr;13(4):221-227. doi: 10.1200/JOP.2016.019182. PMID: 28399384
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472

Recent systematic reviews

Prevalence of highly actionable mutations among Indian patients with advanced non-small cell lung cancer: A systematic review and meta-analysis.
Raman R, Ramamohan V, Rathore A, Jain D, Mohan A, Vashistha V
Asia Pac J Clin Oncol 2023 Feb;19(1):158-171. Epub 2022 May 30 doi: 10.1111/ajco.13802. PMID: 35634796
Molecular-targeted first-line therapy for advanced gastric cancer.
Song H, Zhu J, Lu D
Cochrane Database Syst Rev 2016 Jul 19;7(7):CD011461. doi: 10.1002/14651858.CD011461.pub2. PMID: 27432490Free PMC Article
Short versus long duration infusions of paclitaxel for any advanced adenocarcinoma.
Williams C, Bryant A
Cochrane Database Syst Rev 2011 May 11;2011(5):CD003911. doi: 10.1002/14651858.CD003911.pub2. PMID: 21563139Free PMC Article
Short versus long duration infusions of paclitaxel for any adenocarcinoma.
Williams C, Collingwood M, Simera I, Grafton C
Cochrane Database Syst Rev 2003;(1):CD003911. doi: 10.1002/14651858.CD003911. PMID: 12535492
Short versus long duration infusions of paclitaxel for any adenocarcinoma.
Williams C, Collingwood M, Simera I, Grafton C
Cochrane Database Syst Rev 2002;(4):CD003911. doi: 10.1002/14651858.CD003911. PMID: 12519619

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