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Iris Mixed Cell Melanoma

MedGen UID:
1756478
•Concept ID:
C5420819
•
Neoplastic Process

Definition

A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIris Mixed Cell Melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article

Recent clinical studies

Etiology

Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Clinical and pathologic characteristics of biopsy-proven iris melanoma: a multicenter international study.
Khan S, Finger PT, Yu GP, Razzaq L, Jager MJ, de Keizer RJ, Sandkull P, Seregard S, Gologorsky D, Schefler AC, Murray TG, Kivelä T, Giuliari GP, McGowan H, Simpson ER, Corriveau C, Coupland SE, Damato BE
Arch Ophthalmol 2012 Jan;130(1):57-64. Epub 2011 Sep 12 doi: 10.1001/archophthalmol.2011.286. PMID: 21911649
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Diagnosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Therapy

Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs.
Zhao J, Ye H, Lu Q, Wang K, Chen X, Song J, Wang H, Lu Y, Cheng M, He Z, Zhai Y, Zhang H, Sun J
J Nanobiotechnology 2022 Feb 2;20(1):62. doi: 10.1186/s12951-022-01270-7. PMID: 35109878Free PMC Article
No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Nucleolar organizer regions in iris nevi and melanomas.
Marcus DM, Mawn LA, Egan KM, Albert DM
Am J Ophthalmol 1992 Aug 15;114(2):202-7. doi: 10.1016/s0002-9394(14)73985-6. PMID: 1642296
Iris melanoma seeding through a trabeculectomy site.
Grossniklaus HE, Brown RH, Stulting RD, Blasberg RD
Arch Ophthalmol 1990 Sep;108(9):1287-90. doi: 10.1001/archopht.1990.01070110103033. PMID: 2400348
Trends in incidence of ocular malignant melanoma in Denmark 1943-1982.
Osterlind A
Int J Cancer 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206. PMID: 3610385

Prognosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Clinical prediction guides

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article

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