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Iris melanoma

MedGen UID:
87559
•Concept ID:
C0346373
•
Neoplastic Process
Synonyms: Iris Malignant Melanoma; iris malignant melanoma; Iris Melanoma; iris melanoma; iris melanoma (disease); malignant iris melanoma; Malignant melanoma of iris; Malignant Melanoma of Iris; malignant melanoma of iris; Malignant Melanoma of the Iris; malignant melanoma of the iris; melanoma (disease) of iris; Melanoma of Iris; melanoma of iris; Melanoma of the Iris; melanoma of the iris
SNOMED CT: Iris melanoma (255012009); Malignant melanoma of iris (255012009)
 
HPO: HP:0011524
Monarch Initiative: MONDO:0004064

Definition

Malignant tumor of melanocytes affecting the iris. [from HPO]

Professional guidelines

PubMed

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing.
van Poppelen NM, de Bruyn DP, Bicer T, Verdijk R, Naus N, Mensink H, Paridaens D, de Klein A, Brosens E, Kiliҫ E
Int J Mol Sci 2020 Dec 30;22(1) doi: 10.3390/ijms22010336. PMID: 33396957Free PMC Article
Glaucoma secondary to intraocular tumors: mechanisms and management.
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240

Recent clinical studies

Etiology

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Proton Therapy for 166 Patients with Iris Melanoma: Side Effects and Oncologic Outcomes.
Gollrad J, Böker A, Vitzthum S, Besserer A, Heufelder J, Gauger U, Böhmer D, Budach V, Zeitz O, Joussen AM
Ophthalmol Retina 2023 Mar;7(3):266-274. Epub 2022 Sep 8 doi: 10.1016/j.oret.2022.08.026. PMID: 36087876
Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know.
Bol KF, Donia M, Heegaard S, Kiilgaard JF, Svane IM
Int J Mol Sci 2020 Jul 23;21(15) doi: 10.3390/ijms21155231. PMID: 32718045Free PMC Article
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Diagnosis

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Topography and clinical features of iris melanoma.
Krohn J, Sundal KV, Frøystein T
BMC Ophthalmol 2022 Jan 3;22(1):6. doi: 10.1186/s12886-021-02236-3. PMID: 34980044Free PMC Article
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Therapy

Proton Therapy for 166 Patients with Iris Melanoma: Side Effects and Oncologic Outcomes.
Gollrad J, Böker A, Vitzthum S, Besserer A, Heufelder J, Gauger U, Böhmer D, Budach V, Zeitz O, Joussen AM
Ophthalmol Retina 2023 Mar;7(3):266-274. Epub 2022 Sep 8 doi: 10.1016/j.oret.2022.08.026. PMID: 36087876
Endocapsular artificial iris implantation for iris defects: Reducing symptoms, restoring visual function and improving cosmesis.
Crawford AZ, Freundlich SEN, Lim J, McGhee CNJ
Clin Exp Ophthalmol 2022 Jul;50(5):490-499. Epub 2022 Apr 26 doi: 10.1111/ceo.14083. PMID: 35420244Free PMC Article
The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma.
Ny L, Jespersen H, Karlsson J, Alsén S, Filges S, All-Eriksson C, Andersson B, Carneiro A, Helgadottir H, Levin M, Ljuslinder I, Olofsson Bagge R, Sah VR, Stierner U, Ståhlberg A, Ullenhag G, Nilsson LM, Nilsson JA
Nat Commun 2021 Aug 27;12(1):5155. doi: 10.1038/s41467-021-25332-w. PMID: 34453044Free PMC Article
Glaucoma secondary to intraocular tumors: mechanisms and management.
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240
Management of traumatic hyphema.
Walton W, Von Hagen S, Grigorian R, Zarbin M
Surv Ophthalmol 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x. PMID: 12161209

Prognosis

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing.
van Poppelen NM, de Bruyn DP, Bicer T, Verdijk R, Naus N, Mensink H, Paridaens D, de Klein A, Brosens E, Kiliҫ E
Int J Mol Sci 2020 Dec 30;22(1) doi: 10.3390/ijms22010336. PMID: 33396957Free PMC Article
Variability of Bad Prognosis in Uveal Melanoma.
Shao YF, Echegaray JJ, Singh N, Singh AD
Ophthalmol Retina 2019 Feb;3(2):186-193. Epub 2018 Sep 21 doi: 10.1016/j.oret.2018.09.007. PMID: 31014770
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Clinical prediction guides

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Clinicopathologic analysis of 32 ciliary body tumors.
Goto H, Yamakawa N, Tsubota K, Umazume K, Usui Y
Jpn J Ophthalmol 2021 Mar;65(2):237-249. Epub 2021 Feb 19 doi: 10.1007/s10384-021-00814-y. PMID: 33606097
Variability of Bad Prognosis in Uveal Melanoma.
Shao YF, Echegaray JJ, Singh N, Singh AD
Ophthalmol Retina 2019 Feb;3(2):186-193. Epub 2018 Sep 21 doi: 10.1016/j.oret.2018.09.007. PMID: 31014770
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659

Recent systematic reviews

The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.
Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261

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