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Advanced Carcinosarcoma

MedGen UID:
1757356
•Concept ID:
C5418882
•
Neoplastic Process

Definition

Carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Incorporation of anti-PD1 or anti PD-L1 agents to platinum-based chemotherapy for the primary treatment of advanced or recurrent endometrial cancer. A meta-analysis.
Bartoletti M, Montico M, Lorusso D, Mazzeo R, Oaknin A, Musacchio L, Scambia G, Puglisi F, Pignata S
Cancer Treat Rev 2024 Apr;125:102701. Epub 2024 Feb 27 doi: 10.1016/j.ctrv.2024.102701. PMID: 38422895
Comprehensive review of undifferentiated carcinoma of the pancreas: from epidemiology to treatment.
Imaoka H, Ikeda M, Umemoto K, Sunakawa Y, Ueno M, Ueno H, Ozaka M, Kuwahara T, Okano N, Kanai M, Hisano T, Suzuki Y, Asagi A, Shioji K, Todaka A, Tsuji K, Ikezawa K, Miki I, Komatsu Y, Akutsu N, Yamashita T, Okuyama H, Furuse J, Nagano H
Jpn J Clin Oncol 2023 Aug 30;53(9):764-773. doi: 10.1093/jjco/hyad062. PMID: 37325968Free PMC Article
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690

Recent clinical studies

Etiology

Carcinosarcoma of the ovary: a case-control study.
Rauh-Hain JA, Growdon WB, Rodriguez N, Goodman AK, Boruta DM 2nd, Schorge JO, Horowitz NS, del Carmen MG
Gynecol Oncol 2011 Jun 1;121(3):477-81. Epub 2011 Mar 21 doi: 10.1016/j.ygyno.2011.02.023. PMID: 21420726
A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus: A Gynecologic Oncology Group Study.
Sutton G, Brunetto VL, Kilgore L, Soper JT, McGehee R, Olt G, Lentz SS, Sorosky J, Hsiu JG
Gynecol Oncol 2000 Nov;79(2):147-53. doi: 10.1006/gyno.2000.6001. PMID: 11063636

Diagnosis

An uncommon response to metronomic therapy in a heavily pretreated patient with metastatic carcinosarcoma: a case report.
Gagliato Dde M, Linck RD, Bezerra RO, Souto M, Lopes GL, Baiocchi G, Mano MS
J Med Case Rep 2016 Mar 14;10:60. doi: 10.1186/s13256-016-0837-3. PMID: 26971567Free PMC Article
Carcinosarcoma of the ovary: a case-control study.
Rauh-Hain JA, Growdon WB, Rodriguez N, Goodman AK, Boruta DM 2nd, Schorge JO, Horowitz NS, del Carmen MG
Gynecol Oncol 2011 Jun 1;121(3):477-81. Epub 2011 Mar 21 doi: 10.1016/j.ygyno.2011.02.023. PMID: 21420726
Dermatomyositis as a paraneoplastic syndrome in carcinosarcoma of uterine origin.
Chandiramani M, Joynson C, Panchal R, Symonds RP, Brown LJ, Morgan B, Decatris M
Clin Oncol (R Coll Radiol) 2006 Nov;18(9):641-8. doi: 10.1016/j.clon.2006.07.008. PMID: 17100148

Therapy

An uncommon response to metronomic therapy in a heavily pretreated patient with metastatic carcinosarcoma: a case report.
Gagliato Dde M, Linck RD, Bezerra RO, Souto M, Lopes GL, Baiocchi G, Mano MS
J Med Case Rep 2016 Mar 14;10:60. doi: 10.1186/s13256-016-0837-3. PMID: 26971567Free PMC Article
Carcinosarcoma of the ovary: a case-control study.
Rauh-Hain JA, Growdon WB, Rodriguez N, Goodman AK, Boruta DM 2nd, Schorge JO, Horowitz NS, del Carmen MG
Gynecol Oncol 2011 Jun 1;121(3):477-81. Epub 2011 Mar 21 doi: 10.1016/j.ygyno.2011.02.023. PMID: 21420726
Dermatomyositis as a paraneoplastic syndrome in carcinosarcoma of uterine origin.
Chandiramani M, Joynson C, Panchal R, Symonds RP, Brown LJ, Morgan B, Decatris M
Clin Oncol (R Coll Radiol) 2006 Nov;18(9):641-8. doi: 10.1016/j.clon.2006.07.008. PMID: 17100148
A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus: A Gynecologic Oncology Group Study.
Sutton G, Brunetto VL, Kilgore L, Soper JT, McGehee R, Olt G, Lentz SS, Sorosky J, Hsiu JG
Gynecol Oncol 2000 Nov;79(2):147-53. doi: 10.1006/gyno.2000.6001. PMID: 11063636

Prognosis

Carcinosarcoma of the ovary: a case-control study.
Rauh-Hain JA, Growdon WB, Rodriguez N, Goodman AK, Boruta DM 2nd, Schorge JO, Horowitz NS, del Carmen MG
Gynecol Oncol 2011 Jun 1;121(3):477-81. Epub 2011 Mar 21 doi: 10.1016/j.ygyno.2011.02.023. PMID: 21420726
Aggressive carcinosarcoma of the uterine cervix associated with high levels of granulocyte colony stimulating factor: case report and laboratory correlates.
Connor JP
Gynecol Oncol 2006 Oct;103(1):349-53. Epub 2006 Jun 16 doi: 10.1016/j.ygyno.2006.04.021. PMID: 16782175
A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus: A Gynecologic Oncology Group Study.
Sutton G, Brunetto VL, Kilgore L, Soper JT, McGehee R, Olt G, Lentz SS, Sorosky J, Hsiu JG
Gynecol Oncol 2000 Nov;79(2):147-53. doi: 10.1006/gyno.2000.6001. PMID: 11063636

Clinical prediction guides

Carcinosarcoma of the ovary: a case-control study.
Rauh-Hain JA, Growdon WB, Rodriguez N, Goodman AK, Boruta DM 2nd, Schorge JO, Horowitz NS, del Carmen MG
Gynecol Oncol 2011 Jun 1;121(3):477-81. Epub 2011 Mar 21 doi: 10.1016/j.ygyno.2011.02.023. PMID: 21420726

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