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Advanced Rectal Carcinoma

MedGen UID:
1762574
•Concept ID:
C5418786
•
Neoplastic Process

Definition

Rectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Beyond T, N and M: The impact of tumor deposits on the staging and treatment of colorectal and gastric carcinoma.
Peparini N
Surg Oncol 2018 Jun;27(2):129-137. Epub 2018 Feb 21 doi: 10.1016/j.suronc.2018.02.007. PMID: 29937162
Neoadjuvant treatment intensification or adjuvant chemotherapy for locally advanced carcinoma rectum: The optimum treatment approach remains unresolved.
Mallick S, Benson R, Haresh KP, Rath GK
J Egypt Natl Canc Inst 2015 Dec;27(4):179-85. Epub 2015 Jun 10 doi: 10.1016/j.jnci.2015.05.003. PMID: 26071798
Preoperative versus postoperative treatment for locally advanced rectal carcinoma.
Pasetto LM
Future Oncol 2005 Apr;1(2):209-20. doi: 10.1517/14796694.1.2.209. PMID: 16555993

Recent clinical studies

Etiology

Nodal staging with MRI after neoadjuvant chemo-radiotherapy for locally advanced rectal cancer: a fast and reliable method.
Crimì F, Cabrelle G, Campi C, Schillaci A, Bao QR, Pepe A, Spolverato G, Pucciarelli S, Vernuccio F, Quaia E
Eur Radiol 2024 May;34(5):3205-3214. Epub 2023 Nov 6 doi: 10.1007/s00330-023-10265-3. PMID: 37930408
Factors influencing downstaging after neoadjuvant long-course chemoradiotherapy in rectal carcinoma.
Kohl VKB, Weber K, Brunner M, Geppert CI, Fietkau R, Grützmann R, Semrau S, Merkel S
Int J Colorectal Dis 2022 Jun;37(6):1355-1365. Epub 2022 May 11 doi: 10.1007/s00384-022-04174-y. PMID: 35545701Free PMC Article
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Prognostic significance of clinical and pathological stages on locally advanced rectal carcinoma after neoadjuvant chemoradiotherapy.
Wen B, Zhang L, Wang C, Huang R, Peng H, Zhang T, Dong J, Xiao W, Zeng Z, Liu M, Gao Y
Radiat Oncol 2015 Jun 4;10:124. doi: 10.1186/s13014-015-0425-5. PMID: 26040453Free PMC Article

Diagnosis

Nodal staging with MRI after neoadjuvant chemo-radiotherapy for locally advanced rectal cancer: a fast and reliable method.
Crimì F, Cabrelle G, Campi C, Schillaci A, Bao QR, Pepe A, Spolverato G, Pucciarelli S, Vernuccio F, Quaia E
Eur Radiol 2024 May;34(5):3205-3214. Epub 2023 Nov 6 doi: 10.1007/s00330-023-10265-3. PMID: 37930408
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Preoperative radiotherapy with capecitabine and mitomycin C in locally advanced rectal carcinoma.
Stojanovic S, Popov I, Radosevic-Jelic L, Micev M, Borojevic N, Nikolic V, Krivokapic Z, Kecmanovic D, Gavrilovic D, Kezic I
Cancer Chemother Pharmacol 2011 Sep;68(3):787-93. Epub 2010 Dec 28 doi: 10.1007/s00280-010-1469-8. PMID: 21188380
Preoperative versus postoperative treatment for locally advanced rectal carcinoma.
Pasetto LM
Future Oncol 2005 Apr;1(2):209-20. doi: 10.1517/14796694.1.2.209. PMID: 16555993

Therapy

Which is the best neoadjuvant (pre-surgery) chemoradiation regimen for locally advanced rectal carcinoma? Short or long course of radiation therapy? Do we have new data?
Koukourakis G
J BUON 2020 Jan-Feb;25(1):51-61. PMID: 32277614
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Prognostic significance of clinical and pathological stages on locally advanced rectal carcinoma after neoadjuvant chemoradiotherapy.
Wen B, Zhang L, Wang C, Huang R, Peng H, Zhang T, Dong J, Xiao W, Zeng Z, Liu M, Gao Y
Radiat Oncol 2015 Jun 4;10:124. doi: 10.1186/s13014-015-0425-5. PMID: 26040453Free PMC Article
Preoperative versus postoperative treatment for locally advanced rectal carcinoma.
Pasetto LM
Future Oncol 2005 Apr;1(2):209-20. doi: 10.1517/14796694.1.2.209. PMID: 16555993

Prognosis

Factors influencing downstaging after neoadjuvant long-course chemoradiotherapy in rectal carcinoma.
Kohl VKB, Weber K, Brunner M, Geppert CI, Fietkau R, Grützmann R, Semrau S, Merkel S
Int J Colorectal Dis 2022 Jun;37(6):1355-1365. Epub 2022 May 11 doi: 10.1007/s00384-022-04174-y. PMID: 35545701Free PMC Article
Which is the best neoadjuvant (pre-surgery) chemoradiation regimen for locally advanced rectal carcinoma? Short or long course of radiation therapy? Do we have new data?
Koukourakis G
J BUON 2020 Jan-Feb;25(1):51-61. PMID: 32277614
Beyond T, N and M: The impact of tumor deposits on the staging and treatment of colorectal and gastric carcinoma.
Peparini N
Surg Oncol 2018 Jun;27(2):129-137. Epub 2018 Feb 21 doi: 10.1016/j.suronc.2018.02.007. PMID: 29937162
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article

Clinical prediction guides

Factors influencing downstaging after neoadjuvant long-course chemoradiotherapy in rectal carcinoma.
Kohl VKB, Weber K, Brunner M, Geppert CI, Fietkau R, Grützmann R, Semrau S, Merkel S
Int J Colorectal Dis 2022 Jun;37(6):1355-1365. Epub 2022 May 11 doi: 10.1007/s00384-022-04174-y. PMID: 35545701Free PMC Article
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Multivisceral resection for primary locally advanced rectal carcinoma.
Harris DA, Davies M, Lucas MG, Drew P, Carr ND, Beynon J; Swansea Pelvic Oncology Group
Br J Surg 2011 Apr;98(4):582-8. Epub 2010 Dec 24 doi: 10.1002/bjs.7373. PMID: 21656723
Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival.
Meterissian SH, Skibber JM, Giacco GG, el-Naggar AK, Hess KR, Rich TA
Surgery 1997 May;121(5):479-87. doi: 10.1016/s0039-6060(97)90100-8. PMID: 9142144

Recent systematic reviews

Pre-treatment carcinoembryonic antigen and outcome of patients with rectal cancer receiving neo-adjuvant chemo-radiation and surgical resection: a systematic review and meta-analysis.
Colloca G, Venturino A, Vitucci P
Med Oncol 2017 Sep 7;34(10):177. doi: 10.1007/s12032-017-1037-8. PMID: 28884291

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