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Unresectable Sinonasal Squamous Cell Carcinoma

MedGen UID:
1778363
•Concept ID:
C5447283
•
Neoplastic Process

Definition

Sinonasal squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Sinonasal Squamous Cell Carcinoma

Professional guidelines

PubMed

Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article

Recent clinical studies

Etiology

The SINTART 2 Study. A phase II non-randomised controlled trial of induction chemotherapy, photon-, proton- and carbon-ion-based radiotherapy integration in patients with locally advanced unresectable sinonasal tumours.
Bossi P, Orlandi E, Resteghini C, Vischioni B, Nicolai P, Castelnuovo P, Gambazza S, Locati LD, Turri-Zanoni M, Ferrari M, Facchinetti N, Iacovelli NA, Calareso G, Quattrone P, Cavallo A, Tuzi A, Licitra L
Eur J Cancer 2023 Jul;187:134-143. Epub 2023 Apr 7 doi: 10.1016/j.ejca.2023.03.034. PMID: 37163806
Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability.
Yeung JT, Caminer DM, Young IM, Sughrue ME, Teo C
World Neurosurg 2021 Jun;150:e102-e107. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.092. PMID: 33647490
Outcomes of Patients With Sinonasal Squamous Cell Carcinoma Treated With Particle Therapy Using Protons or Carbon Ions.
Toyomasu Y, Demizu Y, Matsuo Y, Sulaiman NS, Mima M, Nagano F, Terashima K, Tokumaru S, Hayakawa T, Daimon T, Fuwa N, Sakuma H, Nomoto Y, Okimoto T
Int J Radiat Oncol Biol Phys 2018 Aug 1;101(5):1096-1103. Epub 2018 Apr 22 doi: 10.1016/j.ijrobp.2018.04.041. PMID: 29859787
Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article
Potential of helical tomotherapy to reduce dose to the ocular structures for patients treated for unresectable sinonasal cancer.
Chen AM, Sreeraman R, Mathai M, Vijayakumar S, Purdy JA
Am J Clin Oncol 2010 Dec;33(6):595-8. doi: 10.1097/COC.0b013e3181c44535. PMID: 20142725

Diagnosis

Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article
Potential of helical tomotherapy to reduce dose to the ocular structures for patients treated for unresectable sinonasal cancer.
Chen AM, Sreeraman R, Mathai M, Vijayakumar S, Purdy JA
Am J Clin Oncol 2010 Dec;33(6):595-8. doi: 10.1097/COC.0b013e3181c44535. PMID: 20142725

Therapy

Complete remission in a patient with sinonasal squamous cell carcinoma receiving neoadjuvant tislelizumab plus chemotherapy: a case report.
Chen F, Zhang H, Li Y, Liang T, Zhang T
Front Immunol 2024;15:1414529. Epub 2024 Jul 15 doi: 10.3389/fimmu.2024.1414529. PMID: 39076983Free PMC Article
The SINTART 2 Study. A phase II non-randomised controlled trial of induction chemotherapy, photon-, proton- and carbon-ion-based radiotherapy integration in patients with locally advanced unresectable sinonasal tumours.
Bossi P, Orlandi E, Resteghini C, Vischioni B, Nicolai P, Castelnuovo P, Gambazza S, Locati LD, Turri-Zanoni M, Ferrari M, Facchinetti N, Iacovelli NA, Calareso G, Quattrone P, Cavallo A, Tuzi A, Licitra L
Eur J Cancer 2023 Jul;187:134-143. Epub 2023 Apr 7 doi: 10.1016/j.ejca.2023.03.034. PMID: 37163806
Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article

Prognosis

The SINTART 2 Study. A phase II non-randomised controlled trial of induction chemotherapy, photon-, proton- and carbon-ion-based radiotherapy integration in patients with locally advanced unresectable sinonasal tumours.
Bossi P, Orlandi E, Resteghini C, Vischioni B, Nicolai P, Castelnuovo P, Gambazza S, Locati LD, Turri-Zanoni M, Ferrari M, Facchinetti N, Iacovelli NA, Calareso G, Quattrone P, Cavallo A, Tuzi A, Licitra L
Eur J Cancer 2023 Jul;187:134-143. Epub 2023 Apr 7 doi: 10.1016/j.ejca.2023.03.034. PMID: 37163806
Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability.
Yeung JT, Caminer DM, Young IM, Sughrue ME, Teo C
World Neurosurg 2021 Jun;150:e102-e107. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.092. PMID: 33647490
Outcomes of Patients With Sinonasal Squamous Cell Carcinoma Treated With Particle Therapy Using Protons or Carbon Ions.
Toyomasu Y, Demizu Y, Matsuo Y, Sulaiman NS, Mima M, Nagano F, Terashima K, Tokumaru S, Hayakawa T, Daimon T, Fuwa N, Sakuma H, Nomoto Y, Okimoto T
Int J Radiat Oncol Biol Phys 2018 Aug 1;101(5):1096-1103. Epub 2018 Apr 22 doi: 10.1016/j.ijrobp.2018.04.041. PMID: 29859787
Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article
Potential of helical tomotherapy to reduce dose to the ocular structures for patients treated for unresectable sinonasal cancer.
Chen AM, Sreeraman R, Mathai M, Vijayakumar S, Purdy JA
Am J Clin Oncol 2010 Dec;33(6):595-8. doi: 10.1097/COC.0b013e3181c44535. PMID: 20142725

Clinical prediction guides

The SINTART 2 Study. A phase II non-randomised controlled trial of induction chemotherapy, photon-, proton- and carbon-ion-based radiotherapy integration in patients with locally advanced unresectable sinonasal tumours.
Bossi P, Orlandi E, Resteghini C, Vischioni B, Nicolai P, Castelnuovo P, Gambazza S, Locati LD, Turri-Zanoni M, Ferrari M, Facchinetti N, Iacovelli NA, Calareso G, Quattrone P, Cavallo A, Tuzi A, Licitra L
Eur J Cancer 2023 Jul;187:134-143. Epub 2023 Apr 7 doi: 10.1016/j.ejca.2023.03.034. PMID: 37163806
Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article

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