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Metastatic Nasopharyngeal Nonkeratinizing Carcinoma

MedGen UID:
1780642
•Concept ID:
C5447600
•
Neoplastic Process

Definition

Nasopharyngeal nonkeratinizing carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Nasopharyngeal Nonkeratinizing Carcinoma

Recent clinical studies

Etiology

Clinical features and prognostic factors of nasopharyngeal carcinoma with brain metastases.
Chen K, Shi M, Mo S, Liu T, Zhao Y, Zhang L, Zhao S
Oral Oncol 2024 Apr;151:106738. Epub 2024 Mar 7 doi: 10.1016/j.oraloncology.2024.106738. PMID: 38458037
Induction Chemotherapy Followed by Radiotherapy vs Chemoradiotherapy in Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Dai J, Zhang B, Su Y, Pan Y, Ye Z, Cai R, Qin G, Kong X, Mo Y, Zhang R, Liu Z, Xie Y, Ruan X, Jiang W
JAMA Oncol 2024 Apr 1;10(4):456-463. doi: 10.1001/jamaoncol.2023.6552. PMID: 38329737Free PMC Article
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053

Diagnosis

Clinical features and prognostic factors of nasopharyngeal carcinoma with brain metastases.
Chen K, Shi M, Mo S, Liu T, Zhao Y, Zhang L, Zhao S
Oral Oncol 2024 Apr;151:106738. Epub 2024 Mar 7 doi: 10.1016/j.oraloncology.2024.106738. PMID: 38458037
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Expression of potential therapeutic target SSTR2a in primary and metastatic non-keratinizing nasopharyngeal carcinoma.
Tao L, Chen Y, Shi X, Yu G, Yin W, Huang Y
Virchows Arch 2020 Oct;477(4):573-579. Epub 2020 Apr 23 doi: 10.1007/s00428-020-02815-7. PMID: 32328798
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Nasopharyngeal carcinoma.
Wenig BM
Ann Diagn Pathol 1999 Dec;3(6):374-85. doi: 10.1016/s1092-9134(99)80017-3. PMID: 10594290

Therapy

Induction Chemotherapy Followed by Radiotherapy vs Chemoradiotherapy in Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Dai J, Zhang B, Su Y, Pan Y, Ye Z, Cai R, Qin G, Kong X, Mo Y, Zhang R, Liu Z, Xie Y, Ruan X, Jiang W
JAMA Oncol 2024 Apr 1;10(4):456-463. doi: 10.1001/jamaoncol.2023.6552. PMID: 38329737Free PMC Article
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Immunotherapeutic approaches in nasopharyngeal carcinoma.
Chow JC, Ngan RK, Cheung KM, Cho WC
Expert Opin Biol Ther 2019 Nov;19(11):1165-1172. Epub 2019 Aug 13 doi: 10.1080/14712598.2019.1650910. PMID: 31361154

Prognosis

Clinical features and prognostic factors of nasopharyngeal carcinoma with brain metastases.
Chen K, Shi M, Mo S, Liu T, Zhao Y, Zhang L, Zhao S
Oral Oncol 2024 Apr;151:106738. Epub 2024 Mar 7 doi: 10.1016/j.oraloncology.2024.106738. PMID: 38458037
Construction of Prognostic Nomogram in Patients with N3-Stage Nasopharyngeal Carcinoma.
Cao W, Li X, Yang J, Xing E, Wu W, Ge Y, Wang B
ORL J Otorhinolaryngol Relat Spec 2023;85(4):195-207. Epub 2023 May 5 doi: 10.1159/000530053. PMID: 37232012
A systematic review and recommendations on the use of plasma EBV DNA for nasopharyngeal carcinoma.
Lee AWM, Lee VHF, Ng WT, Strojan P, Saba NF, Rinaldo A, Willems SM, Rodrigo JP, Forastiere AA, Ferlito A
Eur J Cancer 2021 Aug;153:109-122. Epub 2021 Jun 18 doi: 10.1016/j.ejca.2021.05.022. PMID: 34153713
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Nasopharyngeal carcinoma.
Wenig BM
Ann Diagn Pathol 1999 Dec;3(6):374-85. doi: 10.1016/s1092-9134(99)80017-3. PMID: 10594290

Clinical prediction guides

Induction Chemotherapy Followed by Radiotherapy vs Chemoradiotherapy in Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Dai J, Zhang B, Su Y, Pan Y, Ye Z, Cai R, Qin G, Kong X, Mo Y, Zhang R, Liu Z, Xie Y, Ruan X, Jiang W
JAMA Oncol 2024 Apr 1;10(4):456-463. doi: 10.1001/jamaoncol.2023.6552. PMID: 38329737Free PMC Article
Construction of Prognostic Nomogram in Patients with N3-Stage Nasopharyngeal Carcinoma.
Cao W, Li X, Yang J, Xing E, Wu W, Ge Y, Wang B
ORL J Otorhinolaryngol Relat Spec 2023;85(4):195-207. Epub 2023 May 5 doi: 10.1159/000530053. PMID: 37232012
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Expression of potential therapeutic target SSTR2a in primary and metastatic non-keratinizing nasopharyngeal carcinoma.
Tao L, Chen Y, Shi X, Yu G, Yin W, Huang Y
Virchows Arch 2020 Oct;477(4):573-579. Epub 2020 Apr 23 doi: 10.1007/s00428-020-02815-7. PMID: 32328798

Recent systematic reviews

A systematic review and recommendations on the use of plasma EBV DNA for nasopharyngeal carcinoma.
Lee AWM, Lee VHF, Ng WT, Strojan P, Saba NF, Rinaldo A, Willems SM, Rodrigo JP, Forastiere AA, Ferlito A
Eur J Cancer 2021 Aug;153:109-122. Epub 2021 Jun 18 doi: 10.1016/j.ejca.2021.05.022. PMID: 34153713

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