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Distant Metastasis

MedGen UID:
1785231
•Concept ID:
C5441917
•
Pathologic Function
Synonym: Distant Cancer

Definition

A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDistant Metastasis

Professional guidelines

PubMed

Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.
Gauci ML, Aristei C, Becker JC, Blom A, Bataille V, Dreno B, Del Marmol V, Forsea AM, Fargnoli MC, Grob JJ, Gomes F, Hauschild A, Hoeller C, Harwood C, Kelleners-Smeets N, Kaufmann R, Lallas A, Malvehy J, Moreno-Ramirez D, Peris K, Pellacani G, Saiag P, Stratigos AJ, Vieira R, Zalaudek I, van Akkooi ACJ, Lorigan P, Garbe C, Lebbé C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Aug;171:203-231. Epub 2022 Jun 19 doi: 10.1016/j.ejca.2022.03.043. PMID: 35732101
Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring.
Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Advances in diagnosis and treatment of metastatic cervical cancer.
Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673Free PMC Article

Recent clinical studies

Etiology

The value of multimodal treatment in anaplastic thyroid cancer patients with distant metastasis.
Guo H, Lin H
BMC Surg 2024 Mar 4;24(1):79. doi: 10.1186/s12893-024-02375-6. PMID: 38438944Free PMC Article
Poorly differentiated eccrine carcinomas are associated with increased risk for poor outcomes.
Gupta N, Conomikes A, Murad F, Ruiz ES
J Am Acad Dermatol 2023 Jan;88(1):210-212. Epub 2022 Apr 27 doi: 10.1016/j.jaad.2022.04.039. PMID: 35489550
Risk Factors, Prognostic Factors, and Nomograms for Distant Metastasis in Patients With Newly Diagnosed Osteosarcoma: A Population-Based Study.
Chen B, Zeng Y, Liu B, Lu G, Xiang Z, Chen J, Yu Y, Zuo Z, Lin Y, Ma J
Front Endocrinol (Lausanne) 2021;12:672024. Epub 2021 Jul 30 doi: 10.3389/fendo.2021.672024. PMID: 34393996Free PMC Article
Long-Term MINDACT Results Affirm Excellent Prognosis for Clinically and Genetically Low-Risk Early Breast Cancer.
Oncologist 2021 Feb;26 Suppl 2(Suppl 2):S13-S14. Epub 2021 Jan 5 doi: 10.1002/onco.13666. PMID: 33399243Free PMC Article
The prevention and management of distant metastases in women with breast cancer.
Glück S
Cancer Invest 2007 Feb;25(1):6-13. doi: 10.1080/07357900701226974. PMID: 17364551

Diagnosis

The value of multimodal treatment in anaplastic thyroid cancer patients with distant metastasis.
Guo H, Lin H
BMC Surg 2024 Mar 4;24(1):79. doi: 10.1186/s12893-024-02375-6. PMID: 38438944Free PMC Article
Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3.
Li F, Xu T, Chen P, Sun R, Li C, Zhao X, Ou J, Li J, Liu T, Zeng M, Zheng W, Lin Y, Yang L, Li Z, Chen H, Zhang Q
Int J Biol Sci 2022;18(15):5858-5872. Epub 2022 Sep 24 doi: 10.7150/ijbs.76162. PMID: 36263165Free PMC Article
Metastases of malignant neoplasms to the hand.
Żyluk A, Fliciński F
Pol Przegl Chir 2022 Feb 11;94(5):13-17. doi: 10.5604/01.3001.0015.7341. PMID: 36169589
Dermatofibrosarcoma Protuberans Of Trunk In A Male Patient.
Hashmi JZ, Ghafoor A, Rauf Khan Hiraj MU, Chaudhary WA
J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):364-365. doi: 10.55519/JAMC-02-8960. PMID: 35576304
Locoregional and distant recurrences after breast conserving therapy in patients with triple-negative breast cancer: a meta-analysis.
Wang J, Xie X, Wang X, Tang J, Pan Q, Zhang Y, Di M
Surg Oncol 2013 Dec;22(4):247-55. Epub 2013 Oct 12 doi: 10.1016/j.suronc.2013.10.001. PMID: 24144808

Therapy

Melanoma neoantigen vaccines: Are we getting more personal now?
Latifyan S, Haanen JB
Med 2024 Apr 12;5(4):288-290. doi: 10.1016/j.medj.2024.03.004. PMID: 38614074
Vaccines for colorectal cancer: an update.
Sarvizadeh M, Ghasemi F, Tavakoli F, Sadat Khatami S, Razi E, Sharifi H, Biouki NM, Taghizadeh M
J Cell Biochem 2019 Jun;120(6):8815-8828. Epub 2018 Dec 9 doi: 10.1002/jcb.28179. PMID: 30536960
Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC.
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, Kurata T, Chiappori A, Lee KH, de Wit M, Cho BC, Bourhaba M, Quantin X, Tokito T, Mekhail T, Planchard D, Kim YC, Karapetis CS, Hiret S, Ostoros G, Kubota K, Gray JE, Paz-Ares L, de Castro Carpeño J, Faivre-Finn C, Reck M, Vansteenkiste J, Spigel DR, Wadsworth C, Melillo G, Taboada M, Dennis PA, Özgüroğlu M; PACIFIC Investigators
N Engl J Med 2018 Dec 13;379(24):2342-2350. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1809697. PMID: 30280658
Melanoma.
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, Yokoi T, Chiappori A, Lee KH, de Wit M, Cho BC, Bourhaba M, Quantin X, Tokito T, Mekhail T, Planchard D, Kim YC, Karapetis CS, Hiret S, Ostoros G, Kubota K, Gray JE, Paz-Ares L, de Castro Carpeño J, Wadsworth C, Melillo G, Jiang H, Huang Y, Dennis PA, Özgüroğlu M; PACIFIC Investigators
N Engl J Med 2017 Nov 16;377(20):1919-1929. Epub 2017 Sep 8 doi: 10.1056/NEJMoa1709937. PMID: 28885881

Prognosis

Survival After Contralateral Axillary Metastasis in Breast Cancer.
Jung JJ, Cheun JH, Kang E, Shin I, Byeon J, Lee H, Kim HK, Lee HB, Han W, Moon HG
Ann Surg Oncol 2024 Aug;31(8):5189-5196. Epub 2024 May 2 doi: 10.1245/s10434-024-15370-1. PMID: 38695982Free PMC Article
Laryngeal adenoid cystic carcinoma: Radical or conservative surgery?
Lionello M, Canal F, Presotto F, Palumbo R, Rizzotto G, Bertolin A
Am J Otolaryngol 2021 Jul-Aug;42(4):102974. Epub 2021 Feb 16 doi: 10.1016/j.amjoto.2021.102974. PMID: 33652330
APC Promoter Hypermethylation as a Prognostic Marker in Breast Cancer Patients.
Saelee P, Pongtheerat T
Asian Pac J Cancer Prev 2020 Dec 1;21(12):3627-3632. doi: 10.31557/APJCP.2020.21.12.3627. PMID: 33369461Free PMC Article
Ductal adenocarcinoma of the prostate: a Hong Kong case series.
Kan RW, Kan CF, Wong JH, Fu KK, Ng CF, Chan SW
Int Urol Nephrol 2014 Nov;46(11):2133-7. Epub 2014 Jul 31 doi: 10.1007/s11255-014-0793-z. PMID: 25080209
Elevated plasma visfatin levels correlate with poor prognosis of gastric cancer patients.
Lu GW, Wang QJ, Xia MM, Qian J
Peptides 2014 Aug;58:60-4. Epub 2014 Jun 6 doi: 10.1016/j.peptides.2014.05.016. PMID: 24911837

Clinical prediction guides

Systematic review and meta-analysis of prediction models used in cervical cancer.
Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Prognostic value of Ki-67 in nasopharyngeal carcinoma: a meta-analysis.
Li Y, Yue L, Li Y, Zhang Q, Liang X
Biosci Rep 2021 May 28;41(5) doi: 10.1042/BSR20203334. PMID: 33393626Free PMC Article
Anaplastic thyroid carcinoma: Updates on WHO classification, clinicopathological features and staging.
Abe I, Lam AK
Histol Histopathol 2021 Mar;36(3):239-248. Epub 2020 Nov 10 doi: 10.14670/HH-18-277. PMID: 33170501
State-of-the-art preoperative staging of gastric cancer by MDCT and magnetic resonance imaging.
Choi JI, Joo I, Lee JM
World J Gastroenterol 2014 Apr 28;20(16):4546-57. doi: 10.3748/wjg.v20.i16.4546. PMID: 24782607Free PMC Article
Gene-expression assays: new tools to individualize treatment of early-stage breast cancer.
Dobbe E, Gurney K, Kiekow S, Lafferty JS, Kolesar JM
Am J Health Syst Pharm 2008 Jan 1;65(1):23-8. doi: 10.2146/ajhp060352. PMID: 18159035

Recent systematic reviews

Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer.
Zhu JQ, Wu H, Li ZL, Xu XF, Xing H, Wang MD, Jia HD, Liang L, Li C, Sun LY, Wang YG, Shen F, Huang DS, Yang T
Adv Mater 2022 Sep;34(38):e2201651. Epub 2022 Aug 19 doi: 10.1002/adma.202201651. PMID: 35583434
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis.
Gandini S, Zanna I, De Angelis S, Palli D, Raimondi S, Ribero S, Masala G, Suppa M, Bellerba F, Corso F, Nezi L, Nagore E, Caini S
Crit Rev Oncol Hematol 2021 Apr;160:103288. Epub 2021 Mar 3 doi: 10.1016/j.critrevonc.2021.103288. PMID: 33675908
Effect of BRCA germline mutations on breast cancer prognosis: A systematic review and meta-analysis.
Baretta Z, Mocellin S, Goldin E, Olopade OI, Huo D
Medicine (Baltimore) 2016 Oct;95(40):e4975. doi: 10.1097/MD.0000000000004975. PMID: 27749552Free PMC Article

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