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Refractory Malignant Salivary Gland Neoplasm

MedGen UID:
1786322
•Concept ID:
C5447973
•
Neoplastic Process

Definition

A malignant salivary gland neoplasm that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Salivary Gland Neoplasm

Professional guidelines

PubMed

New agents in the treatment for malignancies of the salivary and thyroid glands.
Mehra R, Cohen RB
Hematol Oncol Clin North Am 2008 Dec;22(6):1279-95, xi. doi: 10.1016/j.hoc.2008.08.010. PMID: 19010274Free PMC Article

Recent clinical studies

Etiology

Partial response to RC-48 as palliative treatment in a patient with locallocally advanced carcinoma ex pleomorphic adenoma harboring a HER2 mutation: a case report.
Yu W, Ding C, Li K
Oral Oncol 2023 Nov;146:106541. Epub 2023 Aug 16 doi: 10.1016/j.oraloncology.2023.106541. PMID: 37595449
Nivolumab for recurrent or metastatic head and neck cancer patients with non-squamous cell carcinoma and/or a primary subsite excluded from CheckMate141, a retrospective study.
Ueda Y, Okano S, Enokida T, Fujisawa T, Ito K, Sato M, Tanaka H, Wada A, Tahara M
Oral Oncol 2022 Jul;130:105932. Epub 2022 May 27 doi: 10.1016/j.oraloncology.2022.105932. PMID: 35636078
Pediatric trans-oral submandibular gland excision: A safe and effective technique.
Hughes CA, Brown J
Int J Pediatr Otorhinolaryngol 2017 Feb;93:13-16. Epub 2016 Dec 1 doi: 10.1016/j.ijporl.2016.11.026. PMID: 28109484
Sialendoscopy for Patients with Radioiodine-Induced Sialadenitis and Xerostomia.
Bhayani MK, Acharya V, Kongkiatkamon S, Farah S, Roberts DB, Sterba J, Chambers MS, Lai SY
Thyroid 2015 Jul;25(7):834-8. Epub 2015 May 15 doi: 10.1089/thy.2014.0572. PMID: 25860842Free PMC Article
Prevention of Frey syndrome with superficial temporal fascia interpositioning: a retrospective study.
Sharma R
Int J Oral Maxillofac Surg 2014 Apr;43(4):413-7. Epub 2014 Jan 22 doi: 10.1016/j.ijom.2013.12.001. PMID: 24461587

Diagnosis

Endoscopic multiport resection of a transspatial, retromaxillary tumor.
Godse NR, Alsulaimani S, Sindwani R, Recinos PF
Clin Neurol Neurosurg 2023 Aug;231:107825. Epub 2023 Jun 9 doi: 10.1016/j.clineuro.2023.107825. PMID: 37348316
A Rare Case of Primary Pulmonary Adenoid Cystic Carcinoma and the Diagnostic Challenges on Cytology.
White K, Askeland R, Bohy K
S D Med 2021 Jul;74(7):329-331. PMID: 34449997
Phase I, first-in-human trial of programmed cell death receptor-1 (PD-1) inhibitor, JTX-4014, in adult patients with advanced, refractory, solid tumors.
Papadopoulos KP, Lakhani N, Falchook GS, Riley G, Baeck J, Brown KS, Gordon G, Le L, Wang JS
Cancer Immunol Immunother 2021 Mar;70(3):763-772. Epub 2020 Sep 28 doi: 10.1007/s00262-020-02730-5. PMID: 32989552Free PMC Article
IgG4-related disease: what a hematologist needs to know.
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Refractory Facial Paralysis: A Case Report.
Hsu YW, Lee JT, Liao YS, Nieh S, Cheng CA, Tsai CK
Acta Neurol Taiwan 2017 Jun 15;26(2):68-71. PMID: 29250758

Therapy

Nivolumab for recurrent or metastatic head and neck cancer patients with non-squamous cell carcinoma and/or a primary subsite excluded from CheckMate141, a retrospective study.
Ueda Y, Okano S, Enokida T, Fujisawa T, Ito K, Sato M, Tanaka H, Wada A, Tahara M
Oral Oncol 2022 Jul;130:105932. Epub 2022 May 27 doi: 10.1016/j.oraloncology.2022.105932. PMID: 35636078
First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy.
Diamond JR, Boni V, Lim E, Nowakowski G, Cordoba R, Morillo D, Valencia R, Genvresse I, Merz C, Boix O, Frigault MM, Greer JM, Hamdy AM, Huang X, Izumi R, Wong H, Moreno V
Clin Cancer Res 2022 Apr 1;28(7):1285-1293. doi: 10.1158/1078-0432.CCR-21-3617. PMID: 35046056
Pan-Cancer Efficacy of Vemurafenib in BRAF (V600)-Mutant Non-Melanoma Cancers.
Subbiah V, Puzanov I, Blay JY, Chau I, Lockhart AC, Raje NS, Wolf J, Baselga J, Meric-Bernstam F, Roszik J, Diamond EL, Riely GJ, Sherman EJ, Riehl T, Pitcher B, Hyman DM
Cancer Discov 2020 May;10(5):657-663. Epub 2020 Feb 6 doi: 10.1158/2159-8290.CD-19-1265. PMID: 32029534Free PMC Article
Sialendoscopy for Patients with Radioiodine-Induced Sialadenitis and Xerostomia.
Bhayani MK, Acharya V, Kongkiatkamon S, Farah S, Roberts DB, Sterba J, Chambers MS, Lai SY
Thyroid 2015 Jul;25(7):834-8. Epub 2015 May 15 doi: 10.1089/thy.2014.0572. PMID: 25860842Free PMC Article
New agents in the treatment for malignancies of the salivary and thyroid glands.
Mehra R, Cohen RB
Hematol Oncol Clin North Am 2008 Dec;22(6):1279-95, xi. doi: 10.1016/j.hoc.2008.08.010. PMID: 19010274Free PMC Article

Prognosis

Partial response to RC-48 as palliative treatment in a patient with locallocally advanced carcinoma ex pleomorphic adenoma harboring a HER2 mutation: a case report.
Yu W, Ding C, Li K
Oral Oncol 2023 Nov;146:106541. Epub 2023 Aug 16 doi: 10.1016/j.oraloncology.2023.106541. PMID: 37595449
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling.
Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E
Cell Death Dis 2022 Aug 5;13(8):678. doi: 10.1038/s41419-022-05133-9. PMID: 35931701Free PMC Article
First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy.
Diamond JR, Boni V, Lim E, Nowakowski G, Cordoba R, Morillo D, Valencia R, Genvresse I, Merz C, Boix O, Frigault MM, Greer JM, Hamdy AM, Huang X, Izumi R, Wong H, Moreno V
Clin Cancer Res 2022 Apr 1;28(7):1285-1293. doi: 10.1158/1078-0432.CCR-21-3617. PMID: 35046056
IgG4-related disease: what a hematologist needs to know.
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Pediatric trans-oral submandibular gland excision: A safe and effective technique.
Hughes CA, Brown J
Int J Pediatr Otorhinolaryngol 2017 Feb;93:13-16. Epub 2016 Dec 1 doi: 10.1016/j.ijporl.2016.11.026. PMID: 28109484

Clinical prediction guides

Nivolumab for recurrent or metastatic head and neck cancer patients with non-squamous cell carcinoma and/or a primary subsite excluded from CheckMate141, a retrospective study.
Ueda Y, Okano S, Enokida T, Fujisawa T, Ito K, Sato M, Tanaka H, Wada A, Tahara M
Oral Oncol 2022 Jul;130:105932. Epub 2022 May 27 doi: 10.1016/j.oraloncology.2022.105932. PMID: 35636078
First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy.
Diamond JR, Boni V, Lim E, Nowakowski G, Cordoba R, Morillo D, Valencia R, Genvresse I, Merz C, Boix O, Frigault MM, Greer JM, Hamdy AM, Huang X, Izumi R, Wong H, Moreno V
Clin Cancer Res 2022 Apr 1;28(7):1285-1293. doi: 10.1158/1078-0432.CCR-21-3617. PMID: 35046056
Pan-Cancer Efficacy of Vemurafenib in BRAF (V600)-Mutant Non-Melanoma Cancers.
Subbiah V, Puzanov I, Blay JY, Chau I, Lockhart AC, Raje NS, Wolf J, Baselga J, Meric-Bernstam F, Roszik J, Diamond EL, Riely GJ, Sherman EJ, Riehl T, Pitcher B, Hyman DM
Cancer Discov 2020 May;10(5):657-663. Epub 2020 Feb 6 doi: 10.1158/2159-8290.CD-19-1265. PMID: 32029534Free PMC Article
Phase I trial of afatinib and 3-weekly trastuzumab with optimal anti-diarrheal management in patients with HER2-positive metastatic cancer.
Martin N, Isambert N, Gomez-Roca C, Goeldner RG, Zanetta S, Sadrolhefazi B, de Mont-Serrat H, Campone M, Delord JP
Cancer Chemother Pharmacol 2018 Dec;82(6):979-986. Epub 2018 Oct 22 doi: 10.1007/s00280-018-3689-2. PMID: 30350178Free PMC Article
Lack of expression of transforming growth factor-beta type II receptor associated with malignant progression in human salivary gland cell clones.
Azuma M, Yuki T, Tamatani T, Motegi K, Yoshida H, Sato M
Int J Cancer 1996 Jun 11;66(6):802-5. doi: 10.1002/(SICI)1097-0215(19960611)66:6<802::AID-IJC16>3.0.CO;2-4. PMID: 8647653

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