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Refractory Malignant Head and Neck Neoplasm

MedGen UID:
1659739
Concept ID:
C4726631
Neoplastic Process
Synonym: Refractory Head and Neck Cancer

Definition

A malignant head and neck neoplasm that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Ancker OV, Krüger M, Wehland M, Infanger M, Grimm D
Int J Mol Sci 2019 Dec 18;21(1) doi: 10.3390/ijms21010010. PMID: 31861373Free PMC Article
Xing M, Haugen BR, Schlumberger M
Lancet 2013 Mar 23;381(9871):1058-69. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(13)60109-9. PMID: 23668556Free PMC Article

Recent clinical studies

Etiology

Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, Polimeni A, Nuti M, Merlano MC, Mezi S, Marchetti P
Front Immunol 2021;12:705096. Epub 2021 Aug 9 doi: 10.3389/fimmu.2021.705096. PMID: 34434192Free PMC Article
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI
N Engl J Med 2015 Feb 12;372(7):621-30. doi: 10.1056/NEJMoa1406470. PMID: 25671254
Xing M, Haugen BR, Schlumberger M
Lancet 2013 Mar 23;381(9871):1058-69. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(13)60109-9. PMID: 23668556Free PMC Article

Diagnosis

Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Santoro FA, Stoopler ET, Werth VP
Dent Clin North Am 2013 Oct;57(4):597-610. Epub 2013 Aug 12 doi: 10.1016/j.cden.2013.06.002. PMID: 24034068Free PMC Article
Xing M, Haugen BR, Schlumberger M
Lancet 2013 Mar 23;381(9871):1058-69. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(13)60109-9. PMID: 23668556Free PMC Article

Therapy

Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, Polimeni A, Nuti M, Merlano MC, Mezi S, Marchetti P
Front Immunol 2021;12:705096. Epub 2021 Aug 9 doi: 10.3389/fimmu.2021.705096. PMID: 34434192Free PMC Article
Ancker OV, Krüger M, Wehland M, Infanger M, Grimm D
Int J Mol Sci 2019 Dec 18;21(1) doi: 10.3390/ijms21010010. PMID: 31861373Free PMC Article
Cramer JD, Burtness B, Ferris RL
Oral Oncol 2019 Dec;99:104460. Epub 2019 Nov 1 doi: 10.1016/j.oraloncology.2019.104460. PMID: 31683169Free PMC Article
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI
N Engl J Med 2015 Feb 12;372(7):621-30. doi: 10.1056/NEJMoa1406470. PMID: 25671254

Prognosis

Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Pu W, Shi X, Yu P, Zhang M, Liu Z, Tan L, Han P, Wang Y, Ji D, Gan H, Wei W, Lu Z, Qu N, Hu J, Hu X, Luo Z, Li H, Ji Q, Wang J, Zhang X, Wang YL
Nat Commun 2021 Oct 18;12(1):6058. doi: 10.1038/s41467-021-26343-3. PMID: 34663816Free PMC Article
Ancker OV, Krüger M, Wehland M, Infanger M, Grimm D
Int J Mol Sci 2019 Dec 18;21(1) doi: 10.3390/ijms21010010. PMID: 31861373Free PMC Article
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Xing M, Haugen BR, Schlumberger M
Lancet 2013 Mar 23;381(9871):1058-69. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(13)60109-9. PMID: 23668556Free PMC Article

Clinical prediction guides

de Sousa LG, Ferrarotto R
Expert Rev Anticancer Ther 2021 Dec;21(12):1321-1331. Epub 2021 Nov 2 doi: 10.1080/14737140.2021.1996228. PMID: 34689660
Cramer JD, Burtness B, Ferris RL
Oral Oncol 2019 Dec;99:104460. Epub 2019 Nov 1 doi: 10.1016/j.oraloncology.2019.104460. PMID: 31683169Free PMC Article
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI
N Engl J Med 2015 Feb 12;372(7):621-30. doi: 10.1056/NEJMoa1406470. PMID: 25671254
Cortes JE, Pazdur R
J Clin Oncol 1995 Oct;13(10):2643-55. doi: 10.1200/JCO.1995.13.10.2643. PMID: 7595719

Recent systematic reviews

Maciejewski A, Lacka K
Int J Mol Sci 2022 Nov 7;23(21) doi: 10.3390/ijms232113661. PMID: 36362448Free PMC Article
Gao TT, Shan JH, Yang YX, Zhang ZW, Liu SL, Xi M, Liu MZ, Zhao L
BMC Cancer 2022 Sep 17;22(1):992. doi: 10.1186/s12885-022-10086-5. PMID: 36115960Free PMC Article
Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, Polimeni A, Nuti M, Merlano MC, Mezi S, Marchetti P
Front Immunol 2021;12:705096. Epub 2021 Aug 9 doi: 10.3389/fimmu.2021.705096. PMID: 34434192Free PMC Article
Guidi A, Codecà C, Ferrari D
Med Oncol 2018 Feb 13;35(3):37. doi: 10.1007/s12032-018-1096-5. PMID: 29441454
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article

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