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Angiomyxoma

MedGen UID:
1790210
•Concept ID:
C5551004
•
Neoplastic Process
Synonym: Angiomyxomas
SNOMED CT: Angiomyxoma (404083008); Angiomyxoma (57723004)
 
Monarch Initiative: MONDO:0006086

Definition

A benign soft tissue neoplasm characterized by the presence of neoplastic spindle and stellate cells, and vascular proliferation in a myxoid stroma. [from NCI]

Professional guidelines

PubMed

Aggressive Pelvic Angiomyxoma in a Patient with Twin Pregnancy: Diagnosis, Treatment, and Clinical Complications in Light of the Literature.
Aquino CI, Tinelli R, Libretti A, Bertinato R, Boldorini RL, Giana M, Sorrentino F, Nappi L, Remorgida V, Surico D
Medicina (Kaunas) 2023 Aug 3;59(8) doi: 10.3390/medicina59081417. PMID: 37629707Free PMC Article
Treatment Outcomes and Sensitivity to Hormone Therapy of Aggressive Angiomyxoma: A Multicenter, International, Retrospective Study.
Fucà G, Hindi N, Ray-Coquard I, Colia V, Dei Tos AP, Martin-Broto J, Brahmi M, Collini P, Lorusso D, Raspagliesi F, Pantaleo MA, Vincenzi B, Fumagalli E, Gronchi A, Casali PG, Sanfilippo R
Oncologist 2019 Jul;24(7):e536-e541. Epub 2018 Dec 5 doi: 10.1634/theoncologist.2018-0338. PMID: 30518617Free PMC Article

Recent clinical studies

Etiology

Multimodality imaging of diseases of the vagina.
Pulappadi VP, Manchanda S, Dhamija E, Jana M
Br J Radiol 2024 Feb 28;97(1155):513-525. doi: 10.1093/bjr/tqad052. PMID: 38419147
Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Retrospective analysis of clinicopathological features and prognosis for aggressive angiomyxoma of 27 cases in a tertiary center: a 14-year survey and related literature review.
Zou R, Xu H, Shi Y, Wang J, Wang S, Zhu L
Arch Gynecol Obstet 2020 Jul;302(1):219-229. Epub 2020 May 19 doi: 10.1007/s00404-020-05592-5. PMID: 32430760
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

Diagnosis

Aggressive Pelvic Angiomyxoma in a Patient with Twin Pregnancy: Diagnosis, Treatment, and Clinical Complications in Light of the Literature.
Aquino CI, Tinelli R, Libretti A, Bertinato R, Boldorini RL, Giana M, Sorrentino F, Nappi L, Remorgida V, Surico D
Medicina (Kaunas) 2023 Aug 3;59(8) doi: 10.3390/medicina59081417. PMID: 37629707Free PMC Article
Aggressive Angiomyxoma. A case series of eight years of experience.
Gorgulu G, Kole MÇ, Ayaz D, Kuru O, Gokcu M, Sanci M
Ann Ital Chir 2022;93:562-565. PMID: 36353852
Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
Aggressive angiomyxoma.
Sutton BJ, Laudadio J
Arch Pathol Lab Med 2012 Feb;136(2):217-21. doi: 10.5858/arpa.2011-0056-RS. PMID: 22288973

Therapy

Hormonal therapies in uterine sarcomas, aggressive angiomyxoma, and desmoid-type fibromatosis.
Pannier D, Cordoba A, Ryckewaert T, Robin YM, Penel N
Crit Rev Oncol Hematol 2019 Nov;143:62-66. Epub 2019 Aug 31 doi: 10.1016/j.critrevonc.2019.08.007. PMID: 31494310
Huge abdominal and perineal aggressive angiomyxoma: A misdiagnosed case report and literature review.
Ma J, Wan J, Jiang B, Wang H, Zhang W, Zhang X
Cell Mol Biol (Noisy-le-grand) 2018 May 15;64(6):110-113. PMID: 29808809
Paravaginal aggressive angiomyxoma.
Abu Saadeh F, Galvin D, Alsharbaty MJ, Gleeson N
BMJ Case Rep 2015 Apr 1;2015 doi: 10.1136/bcr-2014-207287. PMID: 25833906Free PMC Article
Hormonal therapy for aggressive angiomyxoma: a case report and proposed management algorithm.
Schwartz PE, Hui P, McCarthy S
J Low Genit Tract Dis 2014 Apr;18(2):E55-61. doi: 10.1097/LGT.0b013e3182a22019. PMID: 24402356
Aggressive angiomyxoma.
Gay F, Champigneulle J, Tortuyaux JM, Cuny T, Régent D, Laurent-Croisé V
Diagn Interv Imaging 2013 Jun;94(6):657-61. Epub 2013 Feb 26 doi: 10.1016/j.diii.2013.01.009. PMID: 23453353

Prognosis

Aggressive angiomyxoma of the vagina: Case report and review of the literature.
Hidalgo-Zambrano DM, Reyes-Vega DF, Luis Guillermo CA
Rev Colomb Obstet Ginecol 2020 Dec;71(4):384-394. doi: 10.18597/rcog.3527. PMID: 33515445
Retrospective analysis of clinicopathological features and prognosis for aggressive angiomyxoma of 27 cases in a tertiary center: a 14-year survey and related literature review.
Zou R, Xu H, Shi Y, Wang J, Wang S, Zhu L
Arch Gynecol Obstet 2020 Jul;302(1):219-229. Epub 2020 May 19 doi: 10.1007/s00404-020-05592-5. PMID: 32430760
Aggressive angiomyxoma.
Sutton BJ, Laudadio J
Arch Pathol Lab Med 2012 Feb;136(2):217-21. doi: 10.5858/arpa.2011-0056-RS. PMID: 22288973
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

Clinical prediction guides

Aggressive Pelvic Angiomyxoma in a Patient with Twin Pregnancy: Diagnosis, Treatment, and Clinical Complications in Light of the Literature.
Aquino CI, Tinelli R, Libretti A, Bertinato R, Boldorini RL, Giana M, Sorrentino F, Nappi L, Remorgida V, Surico D
Medicina (Kaunas) 2023 Aug 3;59(8) doi: 10.3390/medicina59081417. PMID: 37629707Free PMC Article
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Hafeez F, Krakowski AC, Lian CG, Nazarian RM, Maleszewski JJ
Histopathology 2022 May;80(6):1001-1003. Epub 2022 Mar 17 doi: 10.1111/his.14568. PMID: 34532875
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

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