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Testicular seminoma

MedGen UID:
1790467
Concept ID:
C5551428
Neoplastic Process
Synonyms: Seminoma of testis; Seminoma of Testis; seminoma of testis; Seminoma of the Testis; seminoma of the testis; seminoma testis; Seminomatous germ cell tumor of testis; seminomatous germ cell tumor of testis; seminomatous germ cell tumour of testis; Testicular Seminoma; testicular seminoma; testicular seminoma (disease); Testicular Seminoma Pure; testicular seminoma Pure; testicular seminomatous germ cell tumor; Testicular seminomatous germ cell tumor; testicular seminomatous germ cell tumour; testis seminoma
SNOMED CT: Seminoma of testis (255107005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0100617
Monarch Initiative: MONDO:0003669
Orphanet: ORPHA842

Definition

The presence of a seminoma, an undifferentiated germ cell tumor of the testis. [from HPO]

Conditions with this feature

Silver-Russell syndrome 1
MedGen UID:
1718472
Concept ID:
C5393125
Disease or Syndrome
Silver-Russell Syndrome (SRS) is typically characterized by asymmetric gestational growth restriction resulting in affected individuals being born small for gestational age, with relative macrocephaly at birth (head circumference =1.5 SD above birth weight and/or length), prominent forehead usually with frontal bossing, and frequently body asymmetry. This is followed by postnatal growth failure, and in some cases progressive limb length discrepancy and feeding difficulties. Additional clinical features include triangular facies, fifth-finger clinodactyly, and micrognathia with narrow chin. Except for the limb length asymmetry, the growth failure is proportionate and head growth normal. The average adult height in untreated individuals is ~3.1±1.4 SD below the mean. The Netchine-Harbison Clinical Scoring System (NH-CSS) is a sensitive diagnostic scoring system. Clinical diagnosis can be established in an individual who meets at least four of the NH-CSS clinical criteria – prominent forehead/frontal bossing and relative macrocephaly at birth plus two additional findings – and in whom other disorders have been ruled out.

Professional guidelines

PubMed

Mrinakova B, Kajo K, Lehotska V, Ondrusova M, Balogova S, Pinakova Z, Novotna V, Usakova V, Fedorkova L, Waczulikova I, Kausitz J, Ondrus D
Neoplasma 2021 May;68(3):613-620. Epub 2021 Jan 28 doi: 10.4149/neo_2021_200630N677. PMID: 33502887
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Pearce SM, Liauw SL, Eggener SE
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Recent clinical studies

Etiology

Rosen DB, Tan AJN, Pursley J, Kamran SC
World J Urol 2023 Dec;41(12):3895-3903. Epub 2023 Nov 18 doi: 10.1007/s00345-023-04674-8. PMID: 37979002
Farkouh A, Shete K, Cheng KW, Buell MI, Hu B
Urol Oncol 2023 Dec;41(12):476-482. Epub 2023 Nov 14 doi: 10.1016/j.urolonc.2023.10.008. PMID: 37968167
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816

Diagnosis

Jansson AK, Söderling J, Reutfors J, Thor A, Sköld C, Cohn-Cedermark G, Ståhl O, Smedby KE, Pettersson A, Glimelius I
Br J Cancer 2023 Jun;128(12):2261-2269. Epub 2023 Apr 24 doi: 10.1038/s41416-023-02260-8. PMID: 37088800Free PMC Article
Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EURACAN
Ann Oncol 2022 Apr;33(4):362-375. Epub 2022 Jan 19 doi: 10.1016/j.annonc.2022.01.002. PMID: 35065204
Liu R, Lei Z, Li A, Jiang Y, Ji J
Medicine (Baltimore) 2019 Nov;98(45):e17937. doi: 10.1097/MD.0000000000017937. PMID: 31702681Free PMC Article
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
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Therapy

Mansur MB, deSouza NM, Natrajan R, Abegglen LM, Schiffman JD, Greaves M
Nat Ecol Evol 2023 Nov;7(11):1761-1770. Epub 2023 Aug 24 doi: 10.1038/s41559-023-02159-w. PMID: 37620552
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816
Reddy EK, Burke M, Giri S, Krishnan L, Gemer L, Evans R, Mebust WK, Wiegel J
J Natl Med Assoc 1990 Sep;82(9):651-5. PMID: 2120460Free PMC Article
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Prognosis

Expert Panel on Urological Imaging, Schieda N, Oto A, Allen BC, Akin O, Barker SJ, Fulgham PF, Gettle LM, Maranchie JK, Patel BN, Schuster DM, Smith D, Turkbey IB, Lockhart ME
J Am Coll Radiol 2022 May;19(5S):S194-S207. doi: 10.1016/j.jacr.2022.02.009. PMID: 35550802
Albany C, Kesler K, Cary C
Curr Oncol Rep 2019 Jan 21;21(1):5. doi: 10.1007/s11912-019-0758-6. PMID: 30666469
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816
Reddy EK, Burke M, Giri S, Krishnan L, Gemer L, Evans R, Mebust WK, Wiegel J
J Natl Med Assoc 1990 Sep;82(9):651-5. PMID: 2120460Free PMC Article
Aygun C, Slawson RG, Bajaj K, Salazar OM
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Clinical prediction guides

Malcher A, Graczyk Z, Bauer H, Stokowy T, Berman A, Smolibowski M, Blaszczyk D, Jedrzejczak P, Yatsenko AN, Kurpisz M
Sci Rep 2023 Oct 2;13(1):16563. doi: 10.1038/s41598-023-43854-9. PMID: 37783880Free PMC Article
Marini M, Tani A, Manetti M, Sgambati E
Acta Histochem 2020 Apr;122(3):151532. Epub 2020 Mar 3 doi: 10.1016/j.acthis.2020.151532. PMID: 32143917
Wang K, Chen Y, Zhao Z, Feng M, Zhang S
Mol Med Rep 2019 Nov;20(5):4013-4022. Epub 2019 Sep 16 doi: 10.3892/mmr.2019.10684. PMID: 31545448Free PMC Article
Albany C, Kesler K, Cary C
Curr Oncol Rep 2019 Jan 21;21(1):5. doi: 10.1007/s11912-019-0758-6. PMID: 30666469
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
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Recent systematic reviews

Farkouh A, Shete K, Cheng KW, Buell MI, Hu B
Urol Oncol 2023 Dec;41(12):476-482. Epub 2023 Nov 14 doi: 10.1016/j.urolonc.2023.10.008. PMID: 37968167
Winter C, Zengerling F, Busch J, Heinzelbecker J, Pfister D, Ruf C, Lackner J, Albers P, Kliesch S, Schmidt S, Bokemeyer C
World J Urol 2022 Dec;40(12):2863-2878. Epub 2022 May 12 doi: 10.1007/s00345-022-04009-z. PMID: 35554637Free PMC Article
Soon JA, Anton A, Torres J, Lawrence R, Parente P, McKendrick J, Davis ID, Pezaro C
Support Care Cancer 2019 Feb;27(2):373-382. Epub 2018 Oct 22 doi: 10.1007/s00520-018-4492-7. PMID: 30350189
Giannatempo P, Greco T, Mariani L, Nicolai N, Tana S, Farè E, Raggi D, Piva L, Catanzaro M, Biasoni D, Torelli T, Stagni S, Avuzzi B, Maffezzini M, Landoni G, De Braud F, Gianni AM, Sonpavde G, Salvioni R, Necchi A
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Chung P, Mayhew LA, Warde P, Winquist E, Lukka H; Genitourinary Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
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