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Testicular Seminoma with Syncytiotrophoblastic Cells

MedGen UID:
273634
•Concept ID:
C1515295
•
Neoplastic Process

Definition

A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Seminoma with Syncytiotrophoblastic Cells

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Prognosis

Choriogonadotropin positive seminoma-a clinicopathological and molecular genetic study of 15 cases.
Hes O, Pivovarcikova K, Stehlik J, Martinek P, Vanecek T, Bauleth K, Dolejsova O, Petersson F, Hora M, Perez Montiel D, Peckova K, Branzovsky J, Slouka D, Vodicka J, Kokoskova B, Matej R, Michal M
Ann Diagn Pathol 2014 Apr;18(2):89-94. Epub 2013 Dec 24 doi: 10.1016/j.anndiagpath.2013.12.004. PMID: 24480432
Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors.
Hechelhammer L, Störkel S, Odermatt B, Heitz PU, Jochum W
Virchows Arch 2003 Jul;443(1):28-31. Epub 2003 Jun 3 doi: 10.1007/s00428-003-0835-x. PMID: 12783324
Testicular seminoma with human chorionic gonadotropin production.
Hori K, Uematsu K, Yasoshima H, Yamada A, Sakurai K, Ohya M
Pathol Int 1997 Sep;47(9):592-9. doi: 10.1111/j.1440-1827.1997.tb04547.x. PMID: 9311009
Deoxyribonucleic acid ploidy in seminomas with and without syncytiotrophoblastic cells.
Baretton G, Diebold J, DePascale T, Bussar-Maatz R, Weissbach L, Löhrs U
J Urol 1994 Jan;151(1):67-71. doi: 10.1016/s0022-5347(17)34873-5. PMID: 8254835
The biological and clinical significance of HCG-containing cells in seminoma.
Butcher DN, Gregory WM, Gunter PA, Masters JR, Parkinson MC
Br J Cancer 1985 Apr;51(4):473-8. doi: 10.1038/bjc.1985.68. PMID: 3884029Free PMC Article

Clinical prediction guides

Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases.
Sung MT, Maclennan GT, Lopez-Beltran A, Zhang S, Montironi R, Cheng L
Am J Surg Pathol 2008 Jan;32(1):146-55. doi: 10.1097/PAS.0b013e3181379edf. PMID: 18162782
Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors.
Hechelhammer L, Störkel S, Odermatt B, Heitz PU, Jochum W
Virchows Arch 2003 Jul;443(1):28-31. Epub 2003 Jun 3 doi: 10.1007/s00428-003-0835-x. PMID: 12783324
Testicular seminoma with human chorionic gonadotropin production.
Hori K, Uematsu K, Yasoshima H, Yamada A, Sakurai K, Ohya M
Pathol Int 1997 Sep;47(9):592-9. doi: 10.1111/j.1440-1827.1997.tb04547.x. PMID: 9311009
Deoxyribonucleic acid ploidy in seminomas with and without syncytiotrophoblastic cells.
Baretton G, Diebold J, DePascale T, Bussar-Maatz R, Weissbach L, Löhrs U
J Urol 1994 Jan;151(1):67-71. doi: 10.1016/s0022-5347(17)34873-5. PMID: 8254835
The biological and clinical significance of HCG-containing cells in seminoma.
Butcher DN, Gregory WM, Gunter PA, Masters JR, Parkinson MC
Br J Cancer 1985 Apr;51(4):473-8. doi: 10.1038/bjc.1985.68. PMID: 3884029Free PMC Article

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