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Recurrent Malignant Nongerminomatous Germ Cell Tumor

MedGen UID:
1791050
•Concept ID:
C5554609
•
Neoplastic Process

Definition

The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Nongerminomatous Germ Cell Tumor

Professional guidelines

PubMed

Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience.
Lai IC, Wong TT, Shiau CY, Hu YW, Ho DM, Chang KP, Guo WY, Chang FC, Liang ML, Lee YY, Chen HH, Yen SH, Chen YW
Childs Nerv Syst 2015 May;31(5):683-91. Epub 2015 Mar 8 doi: 10.1007/s00381-015-2623-8. PMID: 25749900
Clinical management of primary central nervous system germ cell tumors.
Matsutani M
Semin Oncol 2004 Oct;31(5):676-83. doi: 10.1053/j.seminoncol.2004.07.010. PMID: 15497121
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Recent clinical studies

Etiology

Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities.
Li B, Zhao S, Li S, Li C, Liu W, Li L, Cui B, Liu X, Chen H, Zhang J, Ren Y, Liu F, Yang M, Jiang T, Liu Y, Qiu X
Neuro Oncol 2024 Jul 5;26(7):1335-1351. doi: 10.1093/neuonc/noae038. PMID: 38430549Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Phase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study.
Fangusaro J, Wu S, MacDonald S, Murphy E, Shaw D, Bartels U, Khatua S, Souweidane M, Lu HM, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G
J Clin Oncol 2019 Dec 1;37(34):3283-3290. Epub 2019 Sep 23 doi: 10.1200/JCO.19.00701. PMID: 31545689Free PMC Article
Human chorionic gonadotropin detection in cerebrospinal fluid of patients with a germinoma and its prognostic significance: assessment by using a highly sensitive enzyme immunoassay.
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi JI, Mishima K, Fujimaki T, Katakami H, Matsutani M, Nishikawa R
J Neurosurg Pediatr 2016 Nov;18(5):573-577. Epub 2016 Jul 8 doi: 10.3171/2016.4.PEDS1658. PMID: 27391806
Medulloblastoma arising from an immature teratoma of the posterior fossa. Case report.
Das S, Muro K, Goldman S, Rajaram V, DiPatri AJ Jr
J Neurosurg 2007 Jan;106(1 Suppl):61-4. doi: 10.3171/ped.2007.106.1.61. PMID: 17233316

Diagnosis

Brain and Spinal Tumors Originating from the Germ Line Cells.
Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Human chorionic gonadotropin detection in cerebrospinal fluid of patients with a germinoma and its prognostic significance: assessment by using a highly sensitive enzyme immunoassay.
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi JI, Mishima K, Fujimaki T, Katakami H, Matsutani M, Nishikawa R
J Neurosurg Pediatr 2016 Nov;18(5):573-577. Epub 2016 Jul 8 doi: 10.3171/2016.4.PEDS1658. PMID: 27391806
Medulloblastoma arising from an immature teratoma of the posterior fossa. Case report.
Das S, Muro K, Goldman S, Rajaram V, DiPatri AJ Jr
J Neurosurg 2007 Jan;106(1 Suppl):61-4. doi: 10.3171/ped.2007.106.1.61. PMID: 17233316

Therapy

A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Phase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study.
Fangusaro J, Wu S, MacDonald S, Murphy E, Shaw D, Bartels U, Khatua S, Souweidane M, Lu HM, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G
J Clin Oncol 2019 Dec 1;37(34):3283-3290. Epub 2019 Sep 23 doi: 10.1200/JCO.19.00701. PMID: 31545689Free PMC Article
Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience.
Lai IC, Wong TT, Shiau CY, Hu YW, Ho DM, Chang KP, Guo WY, Chang FC, Liang ML, Lee YY, Chen HH, Yen SH, Chen YW
Childs Nerv Syst 2015 May;31(5):683-91. Epub 2015 Mar 8 doi: 10.1007/s00381-015-2623-8. PMID: 25749900
Evaluation of neoadjuvant therapy in patients with nongerminomatous malignant germ cell tumors.
Nakamura H, Makino K, Kochi M, Ushio Y, Kuratsu J
J Neurosurg Pediatr 2011 Apr;7(4):431-8. doi: 10.3171/2011.1.PEDS10433. PMID: 21456918
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Prognosis

Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities.
Li B, Zhao S, Li S, Li C, Liu W, Li L, Cui B, Liu X, Chen H, Zhang J, Ren Y, Liu F, Yang M, Jiang T, Liu Y, Qiu X
Neuro Oncol 2024 Jul 5;26(7):1335-1351. doi: 10.1093/neuonc/noae038. PMID: 38430549Free PMC Article
Brain and Spinal Tumors Originating from the Germ Line Cells.
Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Human chorionic gonadotropin detection in cerebrospinal fluid of patients with a germinoma and its prognostic significance: assessment by using a highly sensitive enzyme immunoassay.
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi JI, Mishima K, Fujimaki T, Katakami H, Matsutani M, Nishikawa R
J Neurosurg Pediatr 2016 Nov;18(5):573-577. Epub 2016 Jul 8 doi: 10.3171/2016.4.PEDS1658. PMID: 27391806
Medulloblastoma arising from an immature teratoma of the posterior fossa. Case report.
Das S, Muro K, Goldman S, Rajaram V, DiPatri AJ Jr
J Neurosurg 2007 Jan;106(1 Suppl):61-4. doi: 10.3171/ped.2007.106.1.61. PMID: 17233316

Clinical prediction guides

Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor.
Okamoto M, Yamaguchi S, Ishi Y, Motegi H, Mori T, Hashimoto T, Terashita Y, Hirabayashi S, Sugiyama M, Iguchi A, Cho Y, Manabe A, Houkin K
Oncology 2021;99(1):23-31. Epub 2020 Sep 9 doi: 10.1159/000509395. PMID: 32906115
Primary intracranial germ cell tumors in children 36-year experience of a single center.
Kurucu N, Akyüz C, Varan A, Zorlu F, Aydin B, Söylemezoglu F, Yalcin B, Kutluk T, Büyükpamukcus M
J Cancer Res Ther 2020 Oct-Dec;16(6):1459-1465. doi: 10.4103/jcrt.JCRT_314_18. PMID: 33342813
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571

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