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Recurrent Malignant Nongerminomatous Germ Cell Tumor

MedGen UID:
1791050
•Concept ID:
C5554609
•
Neoplastic Process

Definition

The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Nongerminomatous Germ Cell Tumor

Professional guidelines

PubMed

Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Clinical management of primary central nervous system germ cell tumors.
Matsutani M
Semin Oncol 2004 Oct;31(5):676-83. doi: 10.1053/j.seminoncol.2004.07.010. PMID: 15497121
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Recent clinical studies

Etiology

A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group.
Fonseca A, Xia C, Lorenzo AJ, Krailo M, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Billmire DF, Rodriguez-Galindo C, Frazier AL, Shaikh F
J Clin Oncol 2019 Feb 10;37(5):396-402. Epub 2018 Dec 21 doi: 10.1200/JCO.18.00790. PMID: 30576269Free PMC Article
Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience.
Lai IC, Wong TT, Shiau CY, Hu YW, Ho DM, Chang KP, Guo WY, Chang FC, Liang ML, Lee YY, Chen HH, Yen SH, Chen YW
Childs Nerv Syst 2015 May;31(5):683-91. Epub 2015 Mar 8 doi: 10.1007/s00381-015-2623-8. PMID: 25749900
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Diagnosis

Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group.
Fonseca A, Xia C, Lorenzo AJ, Krailo M, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Billmire DF, Rodriguez-Galindo C, Frazier AL, Shaikh F
J Clin Oncol 2019 Feb 10;37(5):396-402. Epub 2018 Dec 21 doi: 10.1200/JCO.18.00790. PMID: 30576269Free PMC Article
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Therapy

A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group.
Fonseca A, Xia C, Lorenzo AJ, Krailo M, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Billmire DF, Rodriguez-Galindo C, Frazier AL, Shaikh F
J Clin Oncol 2019 Feb 10;37(5):396-402. Epub 2018 Dec 21 doi: 10.1200/JCO.18.00790. PMID: 30576269Free PMC Article
Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience.
Lai IC, Wong TT, Shiau CY, Hu YW, Ho DM, Chang KP, Guo WY, Chang FC, Liang ML, Lee YY, Chen HH, Yen SH, Chen YW
Childs Nerv Syst 2015 May;31(5):683-91. Epub 2015 Mar 8 doi: 10.1007/s00381-015-2623-8. PMID: 25749900
Pineal germ cell tumors.
Matsutani M
Prog Neurol Surg 2009;23:76-85. Epub 2009 Mar 23 doi: 10.1159/000210054. PMID: 19329862
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Prognosis

Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Gemcitabine, paclitaxel, and oxaliplatin (GEMPOX) in the treatment of relapsed/refractory intracranial nongerminomatous germ cell tumors.
Perez-Somarriba M, Moreno-Tejero ML, Rozas MI, Pelaez I, Madero L, Lassaletta A
Pediatr Blood Cancer 2020 Feb;67(2):e28089. Epub 2019 Nov 14 doi: 10.1002/pbc.28089. PMID: 31724795
Treatment results and prognostic factors for intracranial nongerminomatous germ cell tumors: single institute experience.
Lai IC, Wong TT, Shiau CY, Hu YW, Ho DM, Chang KP, Guo WY, Chang FC, Liang ML, Lee YY, Chen HH, Yen SH, Chen YW
Childs Nerv Syst 2015 May;31(5):683-91. Epub 2015 Mar 8 doi: 10.1007/s00381-015-2623-8. PMID: 25749900
Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors: a multiinstitutional retrospective analysis of 41 patients.
Ogawa K, Toita T, Nakamura K, Uno T, Onishi H, Itami J, Shikama N, Saeki N, Yoshii Y, Murayama S
Cancer 2003 Jul 15;98(2):369-76. doi: 10.1002/cncr.11495. PMID: 12872359
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Clinical prediction guides

Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor.
Okamoto M, Yamaguchi S, Ishi Y, Motegi H, Mori T, Hashimoto T, Terashita Y, Hirabayashi S, Sugiyama M, Iguchi A, Cho Y, Manabe A, Houkin K
Oncology 2021;99(1):23-31. Epub 2020 Sep 9 doi: 10.1159/000509395. PMID: 32906115
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571
Therapeutic modalities for pineal region tumors.
Stein BM, Fetell MR
Clin Neurosurg 1985;32:445-55. PMID: 2415284

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