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Cervical Micropapillary Adenocarcinoma

MedGen UID:
1793114
•Concept ID:
C5556673
•
Neoplastic Process
Synonym: Invasive Cervical Micropapillary Adenocarcinoma

Definition

A rare, invasive adenocarcinoma that arises from the cervix and is characterized by a micropapillary architecture. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Micropapillary Adenocarcinoma

Professional guidelines

PubMed

Papillary microcarcinoma of the thyroid gland: current controversies and management.
Rovira A, Nixon IJ, Simo R
Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):110-116. doi: 10.1097/MOO.0000000000000520. PMID: 30844924
Management of differentiated thyroid cancer of the follicular epithelium.
Pacini F
Ann Med 2012 Nov;44(7):651-5. Epub 2011 Jun 13 doi: 10.3109/07853890.2011.590145. PMID: 21668295
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Recent clinical studies

Etiology

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment.
Akhave N, Zhang J, Bayley E, Frank M, Chiou SH, Behrens C, Chen R, Hu X, Parra ER, Lee WC, Swisher S, Solis L, Weissferdt A, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons DL, Heymach JV, Lee JJ, Wistuba II, Andrew Futreal P, Zhang J, Fujimoto J, Reuben A
Lung Cancer 2022 Oct;172:19-28. Epub 2022 Aug 10 doi: 10.1016/j.lungcan.2022.08.007. PMID: 35973335Free PMC Article
Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas.
Wong RW, Ng JHY, Han KC, Leung YP, Shek CM, Cheung KN, Choi CKM, Tse KY, Ip PPC
Mod Pathol 2021 Jan;34(1):207-221. Epub 2020 Jul 22 doi: 10.1038/s41379-020-0627-8. PMID: 32699256
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
Micropapillary Cervical Adenocarcinoma: A Clinicopathologic Study of 44 Cases.
Alvarado-Cabrero I, McCluggage WG, Estevez-Castro R, Pérez-Montiel D, Stolnicu S, Ganesan R, Vella J, Castro R, Canedo-Matute J, Gomez-Cifuentes J, Rivas-Lemus VM, Park KJ, Soslow RA, Oliva E, Valencia-Cedillo R
Am J Surg Pathol 2019 Jun;43(6):802-809. doi: 10.1097/PAS.0000000000001245. PMID: 30864975Free PMC Article
Cervical carcinomas with a micropapillary component: a clinicopathological study of eight cases.
Stewart CJR, Koay MHE, Leslie C, Acott N, Leung YC
Histopathology 2018 Mar;72(4):626-633. Epub 2017 Dec 14 doi: 10.1111/his.13419. PMID: 29034552

Diagnosis

The study of clinicopathologic features of cervical squamous carcinoma with invasive micropapillary like pattern and phenotype.
Wang H, Yang K, Li Q, Su W, Liu X, Feng K, Song H, Li S, Jiang H
Histol Histopathol 2022 Sep;37(9):853-861. Epub 2022 May 5 doi: 10.14670/HH-18-464. PMID: 35510512
Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas.
Wong RW, Ng JHY, Han KC, Leung YP, Shek CM, Cheung KN, Choi CKM, Tse KY, Ip PPC
Mod Pathol 2021 Jan;34(1):207-221. Epub 2020 Jul 22 doi: 10.1038/s41379-020-0627-8. PMID: 32699256
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity.
Stolnicu S, Segura S, Parra-Herran C, Horn LC, Hoang L, Terinte C, Pesci A, Aviel-Ronen S, Kyokawa T, Alvarado-Cabrero I, Oliva E, Soslow RA, Park KJ
Am J Surg Pathol 2020 Jul;44(7):873-880. doi: 10.1097/PAS.0000000000001480. PMID: 32235154Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
Cervical adenocarcinoma with stromal micropapillary pattern.
Toyoda S, Kita T, Sugiura A, Itani Y, Okada H, Nakamura S, Ohbayashi C
Diagn Cytopathol 2016 Feb;44(2):133-6. Epub 2015 Nov 26 doi: 10.1002/dc.23393. PMID: 26608235

Therapy

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment.
Akhave N, Zhang J, Bayley E, Frank M, Chiou SH, Behrens C, Chen R, Hu X, Parra ER, Lee WC, Swisher S, Solis L, Weissferdt A, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons DL, Heymach JV, Lee JJ, Wistuba II, Andrew Futreal P, Zhang J, Fujimoto J, Reuben A
Lung Cancer 2022 Oct;172:19-28. Epub 2022 Aug 10 doi: 10.1016/j.lungcan.2022.08.007. PMID: 35973335Free PMC Article
NIFT-P: Are they indolent tumors? Results of a multi-institutional study.
Chereau N, Greilsamer T, Mirallié E, Sadowski SM, Pusztaszeri M, Triponez F, Baud G, Pattou F, Christou N, Mathonnet M, Brunaud L, Santucci N, Goudet P, Guérin C, Sebag F, Donatini G, Kraimps JL, Tissier F, Lussey-Lepoutre C, Leenhardt L, Menegaux F
Surgery 2019 Jan;165(1):12-16. Epub 2018 Nov 9 doi: 10.1016/j.surg.2018.04.089. PMID: 30420090
Partial cutting of sternothyroid muscle during total thyroidectomy: impact on postoperative vocal outcomes.
Lee HS, Kim SW, Park HS, Park CW, Kim JS, Hong JC, Kim YK, Baek SM, Lee KD
ScientificWorldJournal 2013;2013:416535. Epub 2013 Sep 23 doi: 10.1155/2013/416535. PMID: 24174915Free PMC Article
Case of concurrent Riedel's thyroiditis, acute suppurative thyroiditis, and micropapillary carcinoma.
Hong JT, Lee JH, Kim SH, Hong SB, Nam M, Kim YS, Chu YC
Korean J Intern Med 2013 Mar;28(2):236-41. Epub 2013 Feb 27 doi: 10.3904/kjim.2013.28.2.236. PMID: 23526581Free PMC Article
Skip metastase on the left neck lymph nodes of the prostatic adenocarcinoma with neuroendocrine differentiation and accompanying thyroid micropapillary carcinoma.
Sagnak L, Topaloglu H, Gucuk O, Han U, Ersoy H
Pathol Oncol Res 2008 Dec;14(4):493-5. Epub 2008 Apr 2 doi: 10.1007/s12253-008-9029-9. PMID: 18386164

Prognosis

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment.
Akhave N, Zhang J, Bayley E, Frank M, Chiou SH, Behrens C, Chen R, Hu X, Parra ER, Lee WC, Swisher S, Solis L, Weissferdt A, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons DL, Heymach JV, Lee JJ, Wistuba II, Andrew Futreal P, Zhang J, Fujimoto J, Reuben A
Lung Cancer 2022 Oct;172:19-28. Epub 2022 Aug 10 doi: 10.1016/j.lungcan.2022.08.007. PMID: 35973335Free PMC Article
Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas.
Wong RW, Ng JHY, Han KC, Leung YP, Shek CM, Cheung KN, Choi CKM, Tse KY, Ip PPC
Mod Pathol 2021 Jan;34(1):207-221. Epub 2020 Jul 22 doi: 10.1038/s41379-020-0627-8. PMID: 32699256
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
Micropapillary Cervical Adenocarcinoma: A Clinicopathologic Study of 44 Cases.
Alvarado-Cabrero I, McCluggage WG, Estevez-Castro R, Pérez-Montiel D, Stolnicu S, Ganesan R, Vella J, Castro R, Canedo-Matute J, Gomez-Cifuentes J, Rivas-Lemus VM, Park KJ, Soslow RA, Oliva E, Valencia-Cedillo R
Am J Surg Pathol 2019 Jun;43(6):802-809. doi: 10.1097/PAS.0000000000001245. PMID: 30864975Free PMC Article
Cervical carcinomas with a micropapillary component: a clinicopathological study of eight cases.
Stewart CJR, Koay MHE, Leslie C, Acott N, Leung YC
Histopathology 2018 Mar;72(4):626-633. Epub 2017 Dec 14 doi: 10.1111/his.13419. PMID: 29034552

Clinical prediction guides

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment.
Akhave N, Zhang J, Bayley E, Frank M, Chiou SH, Behrens C, Chen R, Hu X, Parra ER, Lee WC, Swisher S, Solis L, Weissferdt A, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons DL, Heymach JV, Lee JJ, Wistuba II, Andrew Futreal P, Zhang J, Fujimoto J, Reuben A
Lung Cancer 2022 Oct;172:19-28. Epub 2022 Aug 10 doi: 10.1016/j.lungcan.2022.08.007. PMID: 35973335Free PMC Article
Diagnostic strategy of fine needle aspiration cytology of cystic cervical lymph node metastasis from papillary thyroid carcinoma.
Li Q, Liu Y, Zhang G, Long H, Jiang Y, Su X
Diagn Cytopathol 2022 Jul;50(7):350-356. Epub 2022 Apr 12 doi: 10.1002/dc.24963. PMID: 35412028
Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas.
Wong RW, Ng JHY, Han KC, Leung YP, Shek CM, Cheung KN, Choi CKM, Tse KY, Ip PPC
Mod Pathol 2021 Jan;34(1):207-221. Epub 2020 Jul 22 doi: 10.1038/s41379-020-0627-8. PMID: 32699256
Micropapillary Cervical Adenocarcinoma: A Clinicopathologic Study of 44 Cases.
Alvarado-Cabrero I, McCluggage WG, Estevez-Castro R, Pérez-Montiel D, Stolnicu S, Ganesan R, Vella J, Castro R, Canedo-Matute J, Gomez-Cifuentes J, Rivas-Lemus VM, Park KJ, Soslow RA, Oliva E, Valencia-Cedillo R
Am J Surg Pathol 2019 Jun;43(6):802-809. doi: 10.1097/PAS.0000000000001245. PMID: 30864975Free PMC Article
Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature.
Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E
Am J Surg Pathol 2007 Nov;31(11):1683-94. doi: 10.1097/PAS.0b013e3180dc928c. PMID: 18059225

Recent systematic reviews

Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence.
Rammal R, Wasserman JK, Singhi AD, Griffith CC, Seethala RR
Endocr Pathol 2023 Dec;34(4):471-483. Epub 2023 Oct 4 doi: 10.1007/s12022-023-09787-9. PMID: 37792156

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