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Endocervical Adenocarcinoma, Usual-Type

MedGen UID:
266095
•Concept ID:
C1266059
•
Neoplastic Process
Synonyms: Adenocarcinoma, Endocervical Type; Adenocarcinoma, endocervical type; Cervical Adenocarcinoma, Usual Type; Cervical Adenocarcinoma, Usual-Type; Cervical Mucinous Adenocarcinoma, Endocervical Type; Cervical Mucinous Adenocarcinoma, Endocervical-Type; Endocervical Adenocarcinoma, Usual Type
SNOMED CT: Adenocarcinoma, endocervical type (128682003)

Definition

A cervical adenocarcinoma in which 0-50% of malignant cells contain intracytoplasmic mucin. It is the most common subtype of cervical adenocarcinoma and represents 75% of all invasive cervical adenocarcinomas. The neoplastic epithelium shows a pseudostratified architecture and the malignant cells have enlarged, elongated, and hyperchromatic nuclei. Historically, usual-type cervical adenocarcinomas were termed ""endocervical-type"". [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndocervical Adenocarcinoma, Usual-Type

Professional guidelines

PubMed

Impact of Histopathological Risk Factors on the Treatment of Stage IB-IIB Uterine Cervical Cancer.
Shimada M, Tokunaga H, Kigawa J, Yaegashi N
Tohoku J Exp Med 2020 Dec;252(4):339-351. doi: 10.1620/tjem.252.339. PMID: 33311005

Recent clinical studies

Etiology

Membranous and nuclear staining of CLDN18 in HPV-independent and HPV-associated endocervical adenocarcinomas.
Du X, Hu Y, Ji X, Sui L, Zheng Q, Song K, Lv T, Chen Y, Zhao H, Dai S, Zhao P, Yao Q
Cancer Med 2023 Jan;12(2):1441-1450. Epub 2022 Jul 21 doi: 10.1002/cam4.5029. PMID: 35861118Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Cervical Glandular Neoplasia: Classification and Staging.
Turashvili G, Park KJ
Surg Pathol Clin 2019 Jun;12(2):281-313. doi: 10.1016/j.path.2019.01.002. PMID: 31097105
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Diagnosis

Gastric-type Endocervical Adenocarcinoma: Comprehensive Cytopathological Analysis and Comparison With Usual-type Endocervical Adenocarcinoma.
Cho H, Park S, Kim HS
In Vivo 2023 May-Jun;37(3):1173-1181. doi: 10.21873/invivo.13192. PMID: 37103100Free PMC Article
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity.
Stolnicu S, Segura S, Parra-Herran C, Horn LC, Hoang L, Terinte C, Pesci A, Aviel-Ronen S, Kyokawa T, Alvarado-Cabrero I, Oliva E, Soslow RA, Park KJ
Am J Surg Pathol 2020 Jul;44(7):873-880. doi: 10.1097/PAS.0000000000001480. PMID: 32235154Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Therapy

Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Uterine Cervix: Clinicopathological and Molecular Characteristics With Special Emphasis on the First Description of Consistent Programmed Death-ligand 1 (PD-L1) Over-expression.
Choi S, Kim SW, Kim HS
Cancer Genomics Proteomics 2021 Sep-Oct;18(5):685-698. doi: 10.21873/cgp.20290. PMID: 34479920Free PMC Article
Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.
Nishio S, Mikami Y, Tokunaga H, Yaegashi N, Satoh T, Saito M, Okamoto A, Kasamatsu T, Miyamoto T, Shiozawa T, Yoshioka Y, Mandai M, Kojima A, Takehara K, Kaneki E, Kobayashi H, Kaku T, Ushijima K, Kamura T
Gynecol Oncol 2019 Apr;153(1):13-19. Epub 2019 Jan 29 doi: 10.1016/j.ygyno.2019.01.022. PMID: 30709650
Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival.
Spaans VM, Scheunhage DA, Barzaghi B, de Kroon CD, Fleuren GJ, Bosse T, Jordanova ES
Gynecol Oncol 2018 Nov;151(2):196-201. Epub 2018 Sep 24 doi: 10.1016/j.ygyno.2018.09.013. PMID: 30262404
Cervical Adenocarcinoma: A Comparison of the Reproducibility of the World Health Organization 2003 and 2014 Classifications.
Sar A, Duan Q, Khalil M, DiFrancesco LM, Ewanowich C, Lytwyn A, Djordjevic B, Itani D, Lee S, Köbel M, Glaze S, Park E, Duggan MA
J Low Genit Tract Dis 2018 Apr;22(2):132-138. doi: 10.1097/LGT.0000000000000380. PMID: 29474242
Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group.
Kojima A, Shimada M, Mikami Y, Nagao S, Takeshima N, Sugiyama T, Teramoto N, Kiyokawa T, Kigawa J, Nishimura R; Sankai Gynecology Study Group
Int J Gynecol Cancer 2018 Jan;28(1):99-106. doi: 10.1097/IGC.0000000000001145. PMID: 29206664

Prognosis

Membranous and nuclear staining of CLDN18 in HPV-independent and HPV-associated endocervical adenocarcinomas.
Du X, Hu Y, Ji X, Sui L, Zheng Q, Song K, Lv T, Chen Y, Zhao H, Dai S, Zhao P, Yao Q
Cancer Med 2023 Jan;12(2):1441-1450. Epub 2022 Jul 21 doi: 10.1002/cam4.5029. PMID: 35861118Free PMC Article
Gastric-type mucinous endocervical adenocarcinomas: A case report and literature review.
Lu J, Na J, Li Y, Wang X, Wang J, Han S
Front Cell Infect Microbiol 2022;12:917009. Epub 2022 Oct 13 doi: 10.3389/fcimb.2022.917009. PMID: 36310872Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Cervical Glandular Neoplasia: Classification and Staging.
Turashvili G, Park KJ
Surg Pathol Clin 2019 Jun;12(2):281-313. doi: 10.1016/j.path.2019.01.002. PMID: 31097105
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Clinical prediction guides

Tumoral Morphologic Features From Cervical Biopsies That Are Predictive of a Negligible Risk for Nodal Metastasis and Tumor Recurrence in Usual-type Cervical Adenocarcinomas: A Multi-institutional Study.
Wang Y, Chang RJ, Luo RZ, Yu J, Zhang X, Yang X, Quddus MR, Li L, Yang W, Liu A, Jiang Q, Zhao R, Zhu H, Zhou F, Wang Y, Sheng X, Liu LL, Wen YL, Banet N, Sung CJ, Qi Y, Bi R, Li M, Wang Y, Li J, Lin W, Wang Y, Rivera G, Chen H, Holloway SB, Fadare O, Liu J, Wang J, Lea J, Kong B, Zheng W
Am J Surg Pathol 2022 May 1;46(5):713-724. doi: 10.1097/PAS.0000000000001833. PMID: 34753864
Clinical significance of the pattern-based classification in endocervical adenocarcinoma, usual and variants.
Byun JM, Cho HJ, Park HY, Kim YN, Lee KB, Sung MS, Jeong CH, Jeong DH
Int J Clin Oncol 2019 Oct;24(10):1264-1272. Epub 2019 May 28 doi: 10.1007/s10147-019-01472-4. PMID: 31140099
Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas.
Stolnicu S, Barsan I, Hoang L, Patel P, Chiriboga L, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Aug;42(8):989-1000. doi: 10.1097/PAS.0000000000001090. PMID: 29851704Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Pattern classification of endocervical adenocarcinoma: reproducibility and review of criteria.
Rutgers JK, Roma AA, Park KJ, Zaino RJ, Johnson A, Alvarado I, Daya D, Rasty G, Longacre TA, Ronnett BM, Silva EG
Mod Pathol 2016 Sep;29(9):1083-94. Epub 2016 Jun 3 doi: 10.1038/modpathol.2016.94. PMID: 27255163Free PMC Article

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