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Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

MedGen UID:
1793118
•Concept ID:
C5556677
•
Neoplastic Process
Synonym: Cervical Mucinous Adenocarcinoma, NOS

Definition

A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Mucinous Adenocarcinoma, Not Otherwise Specified

Professional guidelines

PubMed

Impact of Histopathological Risk Factors on the Treatment of Stage IB-IIB Uterine Cervical Cancer.
Shimada M, Tokunaga H, Kigawa J, Yaegashi N
Tohoku J Exp Med 2020 Dec;252(4):339-351. doi: 10.1620/tjem.252.339. PMID: 33311005
Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172

Therapy

Clinicopathological characteristics of patients with mucinous adenocarcinoma of the uterine cervix: A retrospective study of 21 cases.
Bonin L, Devouassoux-Shisheboran M, Golfier F
J Gynecol Obstet Hum Reprod 2019 May;48(5):319-327. Epub 2019 Feb 23 doi: 10.1016/j.jogoh.2019.02.002. PMID: 30807852

Prognosis

International Endocervical Adenocarcinoma Criteria and Classification (IECC): An Independent Cohort With Clinical and Molecular Findings.
Ren H, Almadani N, Pors J, Leung S, Ho J, Chow C, Ta M, Park KJ, Stolnicu S, Soslow R, Huntsman D, Gilks BC, Hoang L
Int J Gynecol Pathol 2021 Nov 1;40(6):533-540. doi: 10.1097/PGP.0000000000000764. PMID: 34612210
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172

Clinical prediction guides

Micropapillary Cervical Adenocarcinoma: A Clinicopathologic Study of 44 Cases.
Alvarado-Cabrero I, McCluggage WG, Estevez-Castro R, Pérez-Montiel D, Stolnicu S, Ganesan R, Vella J, Castro R, Canedo-Matute J, Gomez-Cifuentes J, Rivas-Lemus VM, Park KJ, Soslow RA, Oliva E, Valencia-Cedillo R
Am J Surg Pathol 2019 Jun;43(6):802-809. doi: 10.1097/PAS.0000000000001245. PMID: 30864975Free PMC Article
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Prognostic value of histopathology and trends in cervical cancer: a SEER population study.
Vinh-Hung V, Bourgain C, Vlastos G, Cserni G, De Ridder M, Storme G, Vlastos AT
BMC Cancer 2007 Aug 23;7:164. doi: 10.1186/1471-2407-7-164. PMID: 17718897Free PMC Article

Recent systematic reviews

Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics.
Marchocki Z, Cusimano MC, Clarfield L, Kim SR, Fazelzad R, Espin-Garcia O, Bouchard-Fortier G, Rossi EC, Stewart KI, Soliman PT, How JA, Gotlieb WH, Holloway RW, Ianieri MM, Cabrera S, Lim YK, Ferguson SE
Am J Obstet Gynecol 2021 Oct;225(4):367.e1-367.e39. Epub 2021 May 29 doi: 10.1016/j.ajog.2021.05.034. PMID: 34058168

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