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Refractory Cervical Adenocarcinoma

MedGen UID:
1793239
•Concept ID:
C5556798
•
Neoplastic Process

Definition

Cervical adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Cervical Adenocarcinoma

Professional guidelines

PubMed

Camrelizumab and metronomic capecitabine for patients with treatment-refractory solid tumors (McCREST trial).
Zhou C, Shangguan C, Shi M, Xi W, Wu J, Yang H, Guo L, Cai Q, Shi Y, Liu J, Zhang J
Future Oncol 2022 Jul;18(23):2495-2503. Epub 2022 Jun 15 doi: 10.2217/fon-2021-1579. PMID: 35703115
Impact of Histopathological Risk Factors on the Treatment of Stage IB-IIB Uterine Cervical Cancer.
Shimada M, Tokunaga H, Kigawa J, Yaegashi N
Tohoku J Exp Med 2020 Dec;252(4):339-351. doi: 10.1620/tjem.252.339. PMID: 33311005
Cost for treatment and follow-up of thyroid cancer increases according to the severity of disease.
Kim SY, Kim SM, Chang H, Kim BW, Lee YS, Kwon SS, Shin H, Chang HS, Park CS
Head Neck 2019 Jul;41(7):2376-2379. Epub 2019 Feb 19 doi: 10.1002/hed.25706. PMID: 30784141

Recent clinical studies

Etiology

Rethinking the significance of surgery for uterine cervical cancer.
Shimada M, Tsuji K, Shigeta S, Nagai T, Watanabe Z, Tokunaga H, Kigawa J, Yaegashi N
J Obstet Gynaecol Res 2022 Mar;48(3):576-586. Epub 2021 Dec 14 doi: 10.1111/jog.15112. PMID: 34908207
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Impact of Histopathological Risk Factors on the Treatment of Stage IB-IIB Uterine Cervical Cancer.
Shimada M, Tokunaga H, Kigawa J, Yaegashi N
Tohoku J Exp Med 2020 Dec;252(4):339-351. doi: 10.1620/tjem.252.339. PMID: 33311005
Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
Dubey D, Wilson MR, Clarkson B, Giannini C, Gandhi M, Cheville J, Lennon VA, Eggers S, Devine MF, Mandel-Brehm C, Kryzer T, Hinson SR, Khazaie K, Hales C, Kattah J, Pavelko KD, Andrews P, Eaton JE, Jitprapaikulsan J, Mills JR, Flanagan EP, Zekeridou A, Leibovich B, Fryer J, Torre M, Kaufman C, Thoreson JB, Sagen J, Linnoila JJ, DeRisi JL, Howe CL, McKeon A, Pittock SJ
JAMA Neurol 2020 Nov 1;77(11):1420-1429. doi: 10.1001/jamaneurol.2020.2231. PMID: 32744608Free PMC Article
Laparoscopic total esophagectomy.
Swanstrom LL, Hansen P
Arch Surg 1997 Sep;132(9):943-7; discussion 947-9. doi: 10.1001/archsurg.1997.01430330009001. PMID: 9301605

Diagnosis

A register-based study: cough - a frequent phenomenon in the adult population.
Backer V, Porsborg A, Hansen V, Skjold T, Schmid JM, Kehlet M, Torp-Pedersen C, Aasbjerg K
BMC Pulm Med 2022 Nov 19;22(1):426. doi: 10.1186/s12890-022-02228-z. PMID: 36401236Free PMC Article
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 T cells.
Li H, Liu Z, Liu L, Zhang H, Han C, Girard L, Park H, Zhang A, Dong C, Ye J, Rayford A, Peyton M, Li X, Avila K, Cao X, Hu S, Alam MM, Akbay EA, Solis LM, Behrens C, Hernandez-Ruiz S, Lu W, Wistuba I, Heymach JV, Chisamore M, Micklem D, Gabra H, Gausdal G, Lorens JB, Li B, Fu YX, Minna JD, Brekken RA
Cell Rep Med 2022 Mar 15;3(3):100554. doi: 10.1016/j.xcrm.2022.100554. PMID: 35492873Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
Dubey D, Wilson MR, Clarkson B, Giannini C, Gandhi M, Cheville J, Lennon VA, Eggers S, Devine MF, Mandel-Brehm C, Kryzer T, Hinson SR, Khazaie K, Hales C, Kattah J, Pavelko KD, Andrews P, Eaton JE, Jitprapaikulsan J, Mills JR, Flanagan EP, Zekeridou A, Leibovich B, Fryer J, Torre M, Kaufman C, Thoreson JB, Sagen J, Linnoila JJ, DeRisi JL, Howe CL, McKeon A, Pittock SJ
JAMA Neurol 2020 Nov 1;77(11):1420-1429. doi: 10.1001/jamaneurol.2020.2231. PMID: 32744608Free PMC Article
Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer.
Montironi R, Cimadamore A, Lopez-Beltran A, Scarpelli M, Aurilio G, Santoni M, Massari F, Cheng L
Cells 2020 Apr 25;9(5) doi: 10.3390/cells9051073. PMID: 32344931Free PMC Article

Therapy

Camrelizumab and metronomic capecitabine for patients with treatment-refractory solid tumors (McCREST trial).
Zhou C, Shangguan C, Shi M, Xi W, Wu J, Yang H, Guo L, Cai Q, Shi Y, Liu J, Zhang J
Future Oncol 2022 Jul;18(23):2495-2503. Epub 2022 Jun 15 doi: 10.2217/fon-2021-1579. PMID: 35703115
FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies.
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake.
Lee YA, Lee H, Im SW, Song YS, Oh DY, Kang HJ, Won JK, Jung KC, Kwon D, Chung EJ, Hah JH, Paeng JC, Kim JH, Choi J, Kim OH, Oh JM, Ahn BC, Wirth LJ, Shin CH, Kim JI, Park YJ
J Clin Invest 2021 Sep 15;131(18) doi: 10.1172/JCI144847. PMID: 34237031Free PMC Article
Copanlisib: First Global Approval.
Markham A
Drugs 2017 Dec;77(18):2057-2062. doi: 10.1007/s40265-017-0838-6. PMID: 29127587

Prognosis

Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma.
Pu W, Shi X, Yu P, Zhang M, Liu Z, Tan L, Han P, Wang Y, Ji D, Gan H, Wei W, Lu Z, Qu N, Hu J, Hu X, Luo Z, Li H, Ji Q, Wang J, Zhang X, Wang YL
Nat Commun 2021 Oct 18;12(1):6058. doi: 10.1038/s41467-021-26343-3. PMID: 34663816Free PMC Article
Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
Dubey D, Wilson MR, Clarkson B, Giannini C, Gandhi M, Cheville J, Lennon VA, Eggers S, Devine MF, Mandel-Brehm C, Kryzer T, Hinson SR, Khazaie K, Hales C, Kattah J, Pavelko KD, Andrews P, Eaton JE, Jitprapaikulsan J, Mills JR, Flanagan EP, Zekeridou A, Leibovich B, Fryer J, Torre M, Kaufman C, Thoreson JB, Sagen J, Linnoila JJ, DeRisi JL, Howe CL, McKeon A, Pittock SJ
JAMA Neurol 2020 Nov 1;77(11):1420-1429. doi: 10.1001/jamaneurol.2020.2231. PMID: 32744608Free PMC Article
Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer.
Montironi R, Cimadamore A, Lopez-Beltran A, Scarpelli M, Aurilio G, Santoni M, Massari F, Cheng L
Cells 2020 Apr 25;9(5) doi: 10.3390/cells9051073. PMID: 32344931Free PMC Article
The prognostic implications from molecular testing of thyroid cancer.
Ozgursoy OB, Eisele DW, Tufano RP
Otolaryngol Clin North Am 2014 Aug;47(4):595-607. doi: 10.1016/j.otc.2014.04.010. PMID: 25041960

Clinical prediction guides

Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors.
Javle M, King G, Spencer K, Borad MJ
Oncologist 2023 Nov 2;28(11):928-943. doi: 10.1093/oncolo/oyad149. PMID: 37390492Free PMC Article
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 T cells.
Li H, Liu Z, Liu L, Zhang H, Han C, Girard L, Park H, Zhang A, Dong C, Ye J, Rayford A, Peyton M, Li X, Avila K, Cao X, Hu S, Alam MM, Akbay EA, Solis LM, Behrens C, Hernandez-Ruiz S, Lu W, Wistuba I, Heymach JV, Chisamore M, Micklem D, Gabra H, Gausdal G, Lorens JB, Li B, Fu YX, Minna JD, Brekken RA
Cell Rep Med 2022 Mar 15;3(3):100554. doi: 10.1016/j.xcrm.2022.100554. PMID: 35492873Free PMC Article
Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
Dubey D, Wilson MR, Clarkson B, Giannini C, Gandhi M, Cheville J, Lennon VA, Eggers S, Devine MF, Mandel-Brehm C, Kryzer T, Hinson SR, Khazaie K, Hales C, Kattah J, Pavelko KD, Andrews P, Eaton JE, Jitprapaikulsan J, Mills JR, Flanagan EP, Zekeridou A, Leibovich B, Fryer J, Torre M, Kaufman C, Thoreson JB, Sagen J, Linnoila JJ, DeRisi JL, Howe CL, McKeon A, Pittock SJ
JAMA Neurol 2020 Nov 1;77(11):1420-1429. doi: 10.1001/jamaneurol.2020.2231. PMID: 32744608Free PMC Article
The prognostic implications from molecular testing of thyroid cancer.
Ozgursoy OB, Eisele DW, Tufano RP
Otolaryngol Clin North Am 2014 Aug;47(4):595-607. doi: 10.1016/j.otc.2014.04.010. PMID: 25041960
Laparoscopic total esophagectomy.
Swanstrom LL, Hansen P
Arch Surg 1997 Sep;132(9):943-7; discussion 947-9. doi: 10.1001/archsurg.1997.01430330009001. PMID: 9301605

Recent systematic reviews

Will targeted therapy hold its promise? An evidence-based review.
Murdoch D, Sager J
Curr Opin Oncol 2008 Jan;20(1):104-11. doi: 10.1097/CCO.0b013e3282f44b12. PMID: 18043264

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