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Refractory Cervical Adenocarcinoma

MedGen UID:
1793239
•Concept ID:
C5556798
•
Neoplastic Process

Definition

Cervical adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Cervical Adenocarcinoma

Professional guidelines

PubMed

Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors.
Javle M, King G, Spencer K, Borad MJ
Oncologist 2023 Nov 2;28(11):928-943. doi: 10.1093/oncolo/oyad149. PMID: 37390492Free PMC Article
Camrelizumab and metronomic capecitabine for patients with treatment-refractory solid tumors (McCREST trial).
Zhou C, Shangguan C, Shi M, Xi W, Wu J, Yang H, Guo L, Cai Q, Shi Y, Liu J, Zhang J
Future Oncol 2022 Jul;18(23):2495-2503. Epub 2022 Jun 15 doi: 10.2217/fon-2021-1579. PMID: 35703115
Impact of Histopathological Risk Factors on the Treatment of Stage IB-IIB Uterine Cervical Cancer.
Shimada M, Tokunaga H, Kigawa J, Yaegashi N
Tohoku J Exp Med 2020 Dec;252(4):339-351. doi: 10.1620/tjem.252.339. PMID: 33311005

Recent clinical studies

Etiology

Gastric-type adenocarcinoma of the uterine cervix: clinical features and future directions.
Nishio H, Matsuda R, Iwata T, Yamagami W
Jpn J Clin Oncol 2024 May 7;54(5):516-520. doi: 10.1093/jjco/hyae019. PMID: 38366663Free PMC Article
Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA).
Ho AL, Dedecjus M, Wirth LJ, Tuttle RM, Inabnet WB 3rd, Tennvall J, Vaisman F, Bastholt L, Gianoukakis AG, Rodien P, Paschke R, Elisei R, Viola D, So K, Carroll D, Hovey T, Thakre B, Fagin JA; ASTRA investigator group
J Clin Oncol 2022 Jun 10;40(17):1870-1878. Epub 2022 Feb 22 doi: 10.1200/JCO.21.00714. PMID: 35192411Free PMC Article
Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases.
Nunes KS, Matos LL, Cavalheiro BG, Magnabosco FF, Tavares MR, Kulcsar MA, Hoff AO, Kowalski LP, Leite AK
Endocrine 2022 Mar;75(3):814-822. Epub 2021 Oct 19 doi: 10.1007/s12020-021-02901-z. PMID: 34665427
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
The prognostic implications from molecular testing of thyroid cancer.
Ozgursoy OB, Eisele DW, Tufano RP
Otolaryngol Clin North Am 2014 Aug;47(4):595-607. doi: 10.1016/j.otc.2014.04.010. PMID: 25041960

Diagnosis

AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 T cells.
Li H, Liu Z, Liu L, Zhang H, Han C, Girard L, Park H, Zhang A, Dong C, Ye J, Rayford A, Peyton M, Li X, Avila K, Cao X, Hu S, Alam MM, Akbay EA, Solis LM, Behrens C, Hernandez-Ruiz S, Lu W, Wistuba I, Heymach JV, Chisamore M, Micklem D, Gabra H, Gausdal G, Lorens JB, Li B, Fu YX, Minna JD, Brekken RA
Cell Rep Med 2022 Mar 15;3(3):100554. doi: 10.1016/j.xcrm.2022.100554. PMID: 35492873Free PMC Article
Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases.
Nunes KS, Matos LL, Cavalheiro BG, Magnabosco FF, Tavares MR, Kulcsar MA, Hoff AO, Kowalski LP, Leite AK
Endocrine 2022 Mar;75(3):814-822. Epub 2021 Oct 19 doi: 10.1007/s12020-021-02901-z. PMID: 34665427
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
The prognostic implications from molecular testing of thyroid cancer.
Ozgursoy OB, Eisele DW, Tufano RP
Otolaryngol Clin North Am 2014 Aug;47(4):595-607. doi: 10.1016/j.otc.2014.04.010. PMID: 25041960
Anterior hip pain in the adult: an algorithmic approach to diagnosis.
Mansour ES, Steingard MA
J Am Osteopath Assoc 1997 Jan;97(1):32-8. doi: 10.7556/jaoa.1997.97.1.32. PMID: 9029877

Therapy

Pathogenesis and signaling pathways related to iodine-refractory differentiated thyroid cancer.
Zhao S, Zhao Y, Zhao Y, Wang G
Front Endocrinol (Lausanne) 2023;14:1320044. Epub 2024 Jan 19 doi: 10.3389/fendo.2023.1320044. PMID: 38313845Free PMC Article
Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases.
Nunes KS, Matos LL, Cavalheiro BG, Magnabosco FF, Tavares MR, Kulcsar MA, Hoff AO, Kowalski LP, Leite AK
Endocrine 2022 Mar;75(3):814-822. Epub 2021 Oct 19 doi: 10.1007/s12020-021-02901-z. PMID: 34665427
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Copanlisib: First Global Approval.
Markham A
Drugs 2017 Dec;77(18):2057-2062. doi: 10.1007/s40265-017-0838-6. PMID: 29127587
New developments in thyroid cancer.
Haddad RI
J Natl Compr Canc Netw 2013 May;11(5 Suppl):705-7. doi: 10.6004/jnccn.2013.0207. PMID: 23704249

Prognosis

Pathogenesis and signaling pathways related to iodine-refractory differentiated thyroid cancer.
Zhao S, Zhao Y, Zhao Y, Wang G
Front Endocrinol (Lausanne) 2023;14:1320044. Epub 2024 Jan 19 doi: 10.3389/fendo.2023.1320044. PMID: 38313845Free PMC Article
Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases.
Nunes KS, Matos LL, Cavalheiro BG, Magnabosco FF, Tavares MR, Kulcsar MA, Hoff AO, Kowalski LP, Leite AK
Endocrine 2022 Mar;75(3):814-822. Epub 2021 Oct 19 doi: 10.1007/s12020-021-02901-z. PMID: 34665427
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma.
Pu W, Shi X, Yu P, Zhang M, Liu Z, Tan L, Han P, Wang Y, Ji D, Gan H, Wei W, Lu Z, Qu N, Hu J, Hu X, Luo Z, Li H, Ji Q, Wang J, Zhang X, Wang YL
Nat Commun 2021 Oct 18;12(1):6058. doi: 10.1038/s41467-021-26343-3. PMID: 34663816Free PMC Article
The prognostic implications from molecular testing of thyroid cancer.
Ozgursoy OB, Eisele DW, Tufano RP
Otolaryngol Clin North Am 2014 Aug;47(4):595-607. doi: 10.1016/j.otc.2014.04.010. PMID: 25041960

Clinical prediction guides

Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors.
Javle M, King G, Spencer K, Borad MJ
Oncologist 2023 Nov 2;28(11):928-943. doi: 10.1093/oncolo/oyad149. PMID: 37390492Free PMC Article
Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm.
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 T cells.
Li H, Liu Z, Liu L, Zhang H, Han C, Girard L, Park H, Zhang A, Dong C, Ye J, Rayford A, Peyton M, Li X, Avila K, Cao X, Hu S, Alam MM, Akbay EA, Solis LM, Behrens C, Hernandez-Ruiz S, Lu W, Wistuba I, Heymach JV, Chisamore M, Micklem D, Gabra H, Gausdal G, Lorens JB, Li B, Fu YX, Minna JD, Brekken RA
Cell Rep Med 2022 Mar 15;3(3):100554. doi: 10.1016/j.xcrm.2022.100554. PMID: 35492873Free PMC Article
Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA).
Ho AL, Dedecjus M, Wirth LJ, Tuttle RM, Inabnet WB 3rd, Tennvall J, Vaisman F, Bastholt L, Gianoukakis AG, Rodien P, Paschke R, Elisei R, Viola D, So K, Carroll D, Hovey T, Thakre B, Fagin JA; ASTRA investigator group
J Clin Oncol 2022 Jun 10;40(17):1870-1878. Epub 2022 Feb 22 doi: 10.1200/JCO.21.00714. PMID: 35192411Free PMC Article
The prognostic implications from molecular testing of thyroid cancer.
Ozgursoy OB, Eisele DW, Tufano RP
Otolaryngol Clin North Am 2014 Aug;47(4):595-607. doi: 10.1016/j.otc.2014.04.010. PMID: 25041960

Recent systematic reviews

Will targeted therapy hold its promise? An evidence-based review.
Murdoch D, Sager J
Curr Opin Oncol 2008 Jan;20(1):104-11. doi: 10.1097/CCO.0b013e3282f44b12. PMID: 18043264

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