Reduced intensity of muscle tendon reflexes in the lower limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.

Reduced strength of the distal musculature of the legs.

Reduced strength of the distal musculature of the arms.

A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.

Reduced strength of one or more muscles innervated by the facial nerve (the seventh cranial nerve).

Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches.

Muscular atrophy affecting muscles in the distal portions of the extremities.

Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions.