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Decreased circulating apolipoprotein B concentration

MedGen UID:
1814242
•Concept ID:
C5676671
•
Finding
HPO: HP:0034075

Definition

Reduced circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating apolipoprotein B concentration

Conditions with this feature

Hereditary sensory and autonomic neuropathy with spastic paraplegia
MedGen UID:
342492
•Concept ID:
C1850395
•
Disease or Syndrome
This syndrome is characterized by the association of an axonal sensory and autonomic neuropathy with spastic paraplegia.
See: Condition Record
Hereditary sensory and autonomic neuropathy with spastic paraplegia

Professional guidelines

PubMed

Lipoprotein(a) Management: Pharmacological and Apheretic Treatment.
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998
A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy.
Klop B, Wouter Jukema J, Rabelink TJ, Castro Cabezas M
Panminerva Med 2012 Jun;54(2):91-103. PMID: 22525564

Recent clinical studies

Etiology

Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Lipoprotein(a) Management: Pharmacological and Apheretic Treatment.
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998
Heparin extracorporeal LDL precipitation (HELP): an effective apheresis procedure for lowering Lp(a) levels.
Armstrong VW, Schuff-Werner P, Eisenhauer T, Helmhold M, Stix M, Seidel D
Chem Phys Lipids 1994 Jan;67-68:315-21. doi: 10.1016/0009-3084(94)90152-x. PMID: 8187229
Lipoproteins and atherosclerosis.
Babiak J, Rudel LL
Baillieres Clin Endocrinol Metab 1987 Aug;1(3):515-50. doi: 10.1016/s0950-351x(87)80022-8. PMID: 3330421

Diagnosis

Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM
Circulation 2021 Aug 3;144(5):353-364. Epub 2021 Jun 18 doi: 10.1161/CIRCULATIONAHA.121.053797. PMID: 34139859Free PMC Article
Blood lipids and lipoproteins in relation to incidence and mortality risks for CVD and cancer in the prospective EPIC-Heidelberg cohort.
Katzke VA, Sookthai D, Johnson T, Kühn T, Kaaks R
BMC Med 2017 Dec 19;15(1):218. doi: 10.1186/s12916-017-0976-4. PMID: 29254484Free PMC Article
Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients.
Guaita-Esteruelas S, Saavedra-García P, Bosquet A, Borràs J, Girona J, Amiliano K, Rodríguez-Balada M, Heras M, Masana L, Gumà J
Oncologist 2017 Nov;22(11):1309-1315. Epub 2017 Jul 12 doi: 10.1634/theoncologist.2016-0483. PMID: 28701570Free PMC Article
Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins.
Rämö JT, Kaye SM, Jukarainen S, Bogl LH, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Matikainen N, Pietiläinen KH
J Clin Endocrinol Metab 2017 Jan 1;102(1):220-231. doi: 10.1210/jc.2015-3512. PMID: 27809652Free PMC Article
New dimension of statin action on ApoB atherogenicity.
Chapman MJ, Caslake M, Packard C, McTaggart F
Clin Cardiol 2003 Jan;26(1 Suppl 1):I7-10. doi: 10.1002/clc.4960261304. PMID: 12539816Free PMC Article

Therapy

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations.
Taskinen MR, Björnson E, Matikainen N, Söderlund S, Rämö J, Ainola MM, Hakkarainen A, Sihlbom C, Thorsell A, Andersson L, Bergh PO, Henricsson M, Romeo S, Adiels M, Ripatti S, Laakso M, Packard CJ, Borén J
JCI Insight 2022 Oct 10;7(19) doi: 10.1172/jci.insight.160607. PMID: 36040803Free PMC Article
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article
Lipoprotein(a) Management: Pharmacological and Apheretic Treatment.
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998
Effects of moderate exercise on VLDL₁ and Intralipid kinetics in overweight/obese middle-aged men.
Al-Shayji IA, Caslake MJ, Gill JM
Am J Physiol Endocrinol Metab 2012 Feb 1;302(3):E349-55. Epub 2011 Nov 15 doi: 10.1152/ajpendo.00498.2011. PMID: 22094472

Prognosis

Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM
Circulation 2021 Aug 3;144(5):353-364. Epub 2021 Jun 18 doi: 10.1161/CIRCULATIONAHA.121.053797. PMID: 34139859Free PMC Article
Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients.
Guaita-Esteruelas S, Saavedra-García P, Bosquet A, Borràs J, Girona J, Amiliano K, Rodríguez-Balada M, Heras M, Masana L, Gumà J
Oncologist 2017 Nov;22(11):1309-1315. Epub 2017 Jul 12 doi: 10.1634/theoncologist.2016-0483. PMID: 28701570Free PMC Article
Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction.
Buring JE, O'Connor GT, Goldhaber SZ, Rosner B, Herbert PN, Blum CB, Breslow JL, Hennekens CH
Circulation 1992 Jan;85(1):22-9. doi: 10.1161/01.cir.85.1.22. PMID: 1728453

Clinical prediction guides

Systemic Metabolic Signatures of Oral Diseases.
Salminen A, Määttä AM, Mäntylä P, Leskelä J, Pietiäinen M, Buhlin K, Suominen AL, Paju S, Sattler W, Sinisalo J, Pussinen PJ
J Dent Res 2024 Jan;103(1):13-21. Epub 2023 Nov 15 doi: 10.1177/00220345231203562. PMID: 37968796Free PMC Article
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.
Zhang X, Geng T, Li N, Wu L, Wang Y, Zheng D, Guo B, Wang B
Nutrients 2022 Dec 23;15(1) doi: 10.3390/nu15010069. PMID: 36615727Free PMC Article
Attenuation of obesity-induced hyperlipidemia reduces tumor growth.
Hussain A, Lian J, Watts R, Gutiérrez T, Nelson R, Goping IS, Lehner R
Biochim Biophys Acta Mol Cell Biol Lipids 2022 Apr;1867(4):159124. Epub 2022 Feb 9 doi: 10.1016/j.bbalip.2022.159124. PMID: 35150894
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article
Heparin extracorporeal LDL precipitation (HELP): an effective apheresis procedure for lowering Lp(a) levels.
Armstrong VW, Schuff-Werner P, Eisenhauer T, Helmhold M, Stix M, Seidel D
Chem Phys Lipids 1994 Jan;67-68:315-21. doi: 10.1016/0009-3084(94)90152-x. PMID: 8187229

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