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Refractory Anaplastic Large Cell Lymphoma

MedGen UID:
208916
•Concept ID:
C0854821
•
Neoplastic Process
Synonym: Anaplastic Large Cell Lymphoma T- and Null-cell Types Refractory

Definition

Anaplastic large cell lymphoma resistant to treatment. [from NCI]

Professional guidelines

PubMed

Single-drug vinblastine as salvage treatment for refractory or relapsed anaplastic large-cell lymphoma: a report from the French Society of Pediatric Oncology.
Brugières L, Pacquement H, Le Deley MC, Leverger G, Lutz P, Paillard C, Baruchel A, Frappaz D, Nelken B, Lamant L, Patte C
J Clin Oncol 2009 Oct 20;27(30):5056-61. Epub 2009 Sep 8 doi: 10.1200/JCO.2008.20.1764. PMID: 19738127
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Senderowicz AM
Cancer Chemother Pharmacol 2003 Jul;52 Suppl 1:S61-73. Epub 2003 Jun 18 doi: 10.1007/s00280-003-0624-x. PMID: 12819936

Recent clinical studies

Etiology

Allogeneic haematopoietic cell transplant in patients with relapsed/refractory anaplastic large cell lymphoma.
Furqan F, Ahn KW, Chen Y, Kaur M, Abutalib SA, Ahmed N, Ahmed S, Kharfan-Dabaja MA, Friedberg J, Gregory T, Hill L, Sterling C, Barta SK, Shadman M, Perales MA, Zain J, Herrera AF, Sauter C, Hamadani M
Br J Haematol 2023 Jan;200(1):54-63. Epub 2022 Sep 19 doi: 10.1111/bjh.18467. PMID: 36120837Free PMC Article
Targeted based therapy in nodal T-cell lymphomas.
Chihara D, Miljkovic M, Iyer SP, Vega F
Leukemia 2021 Apr;35(4):956-967. Epub 2021 Mar 4 doi: 10.1038/s41375-021-01191-8. PMID: 33664464
Successful outcome with reduced-intensity condition regimen followed by allogeneic hematopoietic stem cell transplantation for relapsed or refractory anaplastic large-cell lymphoma.
Fukano R, Mori T, Fujita N, Kobayashi R, Mitsui T, Kato K, Suzuki R, Suzumiya J, Fukuda T, Shindo M, Maseki N, Shimoyama T, Okada K, Inoue M, Inagaki J, Hashii Y, Sato A, Tabuchi K
Int J Hematol 2019 Dec;110(6):723-728. Epub 2019 Oct 16 doi: 10.1007/s12185-019-02748-1. PMID: 31620968
Outcome of patients with relapsed or refractory anaplastic large cell lymphoma who have failed brentuximab vedotin.
Chihara D, Wong S, Feldman T, Fanale MA, Sanchez L, Connors JM, Savage KJ, Oki Y
Hematol Oncol 2019 Feb;37(1):35-38. Epub 2018 Oct 23 doi: 10.1002/hon.2560. PMID: 30209819
Relapsed or refractory anaplastic large-cell lymphoma in children and adolescents after Berlin-Frankfurt-Muenster (BFM)-type first-line therapy: a BFM-group study.
Woessmann W, Zimmermann M, Lenhard M, Burkhardt B, Rossig C, Kremens B, Lang P, Attarbaschi A, Mann G, Oschlies I, Klapper W, Reiter A
J Clin Oncol 2011 Aug 1;29(22):3065-71. Epub 2011 Jun 27 doi: 10.1200/JCO.2011.34.8417. PMID: 21709186

Diagnosis

Targeted based therapy in nodal T-cell lymphomas.
Chihara D, Miljkovic M, Iyer SP, Vega F
Leukemia 2021 Apr;35(4):956-967. Epub 2021 Mar 4 doi: 10.1038/s41375-021-01191-8. PMID: 33664464
ALK kinase domain mutations in primary anaplastic large cell lymphoma: consequences on NPM-ALK activity and sensitivity to tyrosine kinase inhibitors.
Lovisa F, Cozza G, Cristiani A, Cuzzolin A, Albiero A, Mussolin L, Pillon M, Moro S, Basso G, Rosolen A, Bonvini P
PLoS One 2015;10(4):e0121378. Epub 2015 Apr 13 doi: 10.1371/journal.pone.0121378. PMID: 25874976Free PMC Article
Crizotinib as salvage and maintenance with allogeneic stem cell transplantation for refractory anaplastic large cell lymphoma.
Cleary JM, Rodig S, Barr PM, Shinagare AB, Clark JW, Shapiro GI, Armand P
J Natl Compr Canc Netw 2014 Mar 1;12(3):323-6; quiz 326. doi: 10.6004/jnccn.2014.0034. PMID: 24616538
Relapsed or refractory anaplastic large-cell lymphoma in children and adolescents after Berlin-Frankfurt-Muenster (BFM)-type first-line therapy: a BFM-group study.
Woessmann W, Zimmermann M, Lenhard M, Burkhardt B, Rossig C, Kremens B, Lang P, Attarbaschi A, Mann G, Oschlies I, Klapper W, Reiter A
J Clin Oncol 2011 Aug 1;29(22):3065-71. Epub 2011 Jun 27 doi: 10.1200/JCO.2011.34.8417. PMID: 21709186
Long-term disease control of refractory anaplastic large cell lymphoma with vinblastine.
Garner R, Li Y, Gray B, Zori R, Braylan R, Wall J, Hunger SP
J Pediatr Hematol Oncol 2009 Feb;31(2):145-7. doi: 10.1097/MPH.0b013e31819146f8. PMID: 19194204

Therapy

Targeted based therapy in nodal T-cell lymphomas.
Chihara D, Miljkovic M, Iyer SP, Vega F
Leukemia 2021 Apr;35(4):956-967. Epub 2021 Mar 4 doi: 10.1038/s41375-021-01191-8. PMID: 33664464
A Multicenter, Open-label, Clinical Trial to Assess the Effectiveness and Safety of Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-intensity Conditioning in Relapsed/refractory Anaplastic Large-cell Lymphoma in Children.
Kada A, Fukano R, Mori T, Kamei M, Tanaka F, Ueyama J, Sekimizu M, Osumi T, Mori T, Koga Y, Ohki K, Fujita N, Mitsui T, Saito AM, Hashimoto H, Kobayashi R
Acta Med Okayama 2020 Feb;74(1):89-94. doi: 10.18926/AMO/57959. PMID: 32099255
Outcome of patients with relapsed or refractory anaplastic large cell lymphoma who have failed brentuximab vedotin.
Chihara D, Wong S, Feldman T, Fanale MA, Sanchez L, Connors JM, Savage KJ, Oki Y
Hematol Oncol 2019 Feb;37(1):35-38. Epub 2018 Oct 23 doi: 10.1002/hon.2560. PMID: 30209819
Successful use of brentuximab vedotin for refractory anaplastic large cell lymphoma as a bridging therapy to haploidentical stem cell transplantation and maintenance therapy post-transplantation.
Koh KN, Im HJ, Suh JK, Lee SW, Choi ES, Seo JJ
Pediatr Blood Cancer 2015 Jun;62(6):1063-5. Epub 2015 Jan 16 doi: 10.1002/pbc.25351. PMID: 25641881
Relapsed or refractory anaplastic large-cell lymphoma in children and adolescents after Berlin-Frankfurt-Muenster (BFM)-type first-line therapy: a BFM-group study.
Woessmann W, Zimmermann M, Lenhard M, Burkhardt B, Rossig C, Kremens B, Lang P, Attarbaschi A, Mann G, Oschlies I, Klapper W, Reiter A
J Clin Oncol 2011 Aug 1;29(22):3065-71. Epub 2011 Jun 27 doi: 10.1200/JCO.2011.34.8417. PMID: 21709186

Prognosis

Allogeneic haematopoietic cell transplant in patients with relapsed/refractory anaplastic large cell lymphoma.
Furqan F, Ahn KW, Chen Y, Kaur M, Abutalib SA, Ahmed N, Ahmed S, Kharfan-Dabaja MA, Friedberg J, Gregory T, Hill L, Sterling C, Barta SK, Shadman M, Perales MA, Zain J, Herrera AF, Sauter C, Hamadani M
Br J Haematol 2023 Jan;200(1):54-63. Epub 2022 Sep 19 doi: 10.1111/bjh.18467. PMID: 36120837Free PMC Article
Brentuximab Vedotin and High-dose Methotrexate Administrated Alternately for Refractory Anaplastic Large-cell Lymphoma With Central Nervous System Disease.
Mitsunobu T, Nishikawa T, Kusuda M, Nakagawa S, Kodama Y, Okamoto Y, Kawano Y
J Pediatr Hematol Oncol 2020 Aug;42(6):e456-e458. doi: 10.1097/MPH.0000000000001550. PMID: 31274669
Haematopoietic stem cell transplantation for relapsed or refractory anaplastic large cell lymphoma: a study of children and adolescents in Japan.
Fukano R, Mori T, Kobayashi R, Mitsui T, Fujita N, Iwasaki F, Suzumiya J, Chin M, Goto H, Takahashi Y, Hara J, Park YD, Inoue M, Koga Y, Inagaki J, Sakamaki H, Adachi S, Kawa K, Kato K, Suzuki R
Br J Haematol 2015 Feb;168(4):557-63. Epub 2014 Oct 14 doi: 10.1111/bjh.13167. PMID: 25312752
Crizotinib as salvage and maintenance with allogeneic stem cell transplantation for refractory anaplastic large cell lymphoma.
Cleary JM, Rodig S, Barr PM, Shinagare AB, Clark JW, Shapiro GI, Armand P
J Natl Compr Canc Netw 2014 Mar 1;12(3):323-6; quiz 326. doi: 10.6004/jnccn.2014.0034. PMID: 24616538
Relapsed or refractory anaplastic large-cell lymphoma in children and adolescents after Berlin-Frankfurt-Muenster (BFM)-type first-line therapy: a BFM-group study.
Woessmann W, Zimmermann M, Lenhard M, Burkhardt B, Rossig C, Kremens B, Lang P, Attarbaschi A, Mann G, Oschlies I, Klapper W, Reiter A
J Clin Oncol 2011 Aug 1;29(22):3065-71. Epub 2011 Jun 27 doi: 10.1200/JCO.2011.34.8417. PMID: 21709186

Clinical prediction guides

Allogeneic haematopoietic cell transplant in patients with relapsed/refractory anaplastic large cell lymphoma.
Furqan F, Ahn KW, Chen Y, Kaur M, Abutalib SA, Ahmed N, Ahmed S, Kharfan-Dabaja MA, Friedberg J, Gregory T, Hill L, Sterling C, Barta SK, Shadman M, Perales MA, Zain J, Herrera AF, Sauter C, Hamadani M
Br J Haematol 2023 Jan;200(1):54-63. Epub 2022 Sep 19 doi: 10.1111/bjh.18467. PMID: 36120837Free PMC Article
Relapsed or refractory anaplastic large-cell lymphoma in children and adolescents after Berlin-Frankfurt-Muenster (BFM)-type first-line therapy: a BFM-group study.
Woessmann W, Zimmermann M, Lenhard M, Burkhardt B, Rossig C, Kremens B, Lang P, Attarbaschi A, Mann G, Oschlies I, Klapper W, Reiter A
J Clin Oncol 2011 Aug 1;29(22):3065-71. Epub 2011 Jun 27 doi: 10.1200/JCO.2011.34.8417. PMID: 21709186
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Senderowicz AM
Cancer Chemother Pharmacol 2003 Jul;52 Suppl 1:S61-73. Epub 2003 Jun 18 doi: 10.1007/s00280-003-0624-x. PMID: 12819936
UCN-01 Kyowa Hakko Kogyo Co.
Grosios K
Curr Opin Investig Drugs 2001 Feb;2(2):287-97. PMID: 11816846

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