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Stage 4S Neuroblastoma

MedGen UID:
210046
Concept ID:
C1135161
Neoplastic Process
Synonyms: Neuroblastoma Stage IVS; Neuroblastoma, metastatic; Pepper's Syndrome; Stage IVS Neuroblastoma
SNOMED CT: Neuroblastoma, metastatic (704147007)

Definition

Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Peyam S, Bansal D
Indian J Pediatr 2023 Mar;90(3):213-214. Epub 2023 Jan 25 doi: 10.1007/s12098-023-04477-0. PMID: 36696002
Anand S, Agarwala S, Jain V, Dhua A, Bakhshi S, Jana M, Kandasamy D, Biswas A
Indian J Pediatr 2023 Mar;90(3):220-226. Epub 2022 Sep 16 doi: 10.1007/s12098-022-04341-7. PMID: 36112265
Weintraub M, Waldman E, Koplewitz B, Bloom AI, Gross E, Freeman AI, Revel-Vilk S
Pediatr Blood Cancer 2012 Jul 15;59(1):182-4. Epub 2011 May 16 doi: 10.1002/pbc.23186. PMID: 22605456

Recent clinical studies

Etiology

Anand S, Agarwala S, Jain V, Dhua A, Bakhshi S, Jana M, Kandasamy D, Biswas A
Indian J Pediatr 2023 Mar;90(3):220-226. Epub 2022 Sep 16 doi: 10.1007/s12098-022-04341-7. PMID: 36112265
Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Tas ML, Nagtegaal M, Kraal KCJM, Tytgat GAM, Abeling NGGM, Koster J, Pluijm SMF, Zwaan CM, de Keizer B, Molenaar JJ, van Noesel MM
Pediatr Blood Cancer 2020 Apr;67(4):e28061. Epub 2019 Nov 17 doi: 10.1002/pbc.28061. PMID: 31736229
Ozguven AA, Anak S, Unuvar A, Akcay A, Karakas Z, Ozturk G, Devecioglu O, Agaoğlu L
Indian J Pediatr 2015 May;82(5):450-7. Epub 2014 Oct 2 doi: 10.1007/s12098-014-1578-1. PMID: 25274444
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Diagnosis

Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Tas ML, Nagtegaal M, Kraal KCJM, Tytgat GAM, Abeling NGGM, Koster J, Pluijm SMF, Zwaan CM, de Keizer B, Molenaar JJ, van Noesel MM
Pediatr Blood Cancer 2020 Apr;67(4):e28061. Epub 2019 Nov 17 doi: 10.1002/pbc.28061. PMID: 31736229
Ozguven AA, Anak S, Unuvar A, Akcay A, Karakas Z, Ozturk G, Devecioglu O, Agaoğlu L
Indian J Pediatr 2015 May;82(5):450-7. Epub 2014 Oct 2 doi: 10.1007/s12098-014-1578-1. PMID: 25274444
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320
Matthay KK
J Clin Oncol 1998 Jun;16(6):2003-6. doi: 10.1200/JCO.1998.16.6.2003. PMID: 9626196

Therapy

Mubarak M, Singal AK, Gawdi A
Gulf J Oncolog 2019 May;1(30):81-84. PMID: 31242987
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM
J Clin Oncol 2019 Jan 10;37(2):115-124. Epub 2018 Nov 16 doi: 10.1200/JCO.18.00419. PMID: 30444686Free PMC Article
Veal GJ, Errington J, Sastry J, Chisholm J, Brock P, Morgenstern D, Pritchard-Jones K, Chowdhury T
Cancer Chemother Pharmacol 2016 Apr;77(4):685-92. Epub 2016 Feb 13 doi: 10.1007/s00280-016-2975-0. PMID: 26875154Free PMC Article
Elimam NA, Atra AA, Fayea NY, Al-Asaad TG, Khattab TM, Al-Sulami GA, Felimban SK
Saudi Med J 2006 Nov;27(11):1734-6. PMID: 17106552
Schleiermacher G, Rubie H, Hartmann O, Bergeron C, Chastagner P, Mechinaud F, Michon J; Neuroblastoma Study Group of the French Society of Paediatric Oncology
Br J Cancer 2003 Aug 4;89(3):470-6. doi: 10.1038/sj.bjc.6601154. PMID: 12888814Free PMC Article

Prognosis

Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Tas ML, Nagtegaal M, Kraal KCJM, Tytgat GAM, Abeling NGGM, Koster J, Pluijm SMF, Zwaan CM, de Keizer B, Molenaar JJ, van Noesel MM
Pediatr Blood Cancer 2020 Apr;67(4):e28061. Epub 2019 Nov 17 doi: 10.1002/pbc.28061. PMID: 31736229
Ozguven AA, Anak S, Unuvar A, Akcay A, Karakas Z, Ozturk G, Devecioglu O, Agaoğlu L
Indian J Pediatr 2015 May;82(5):450-7. Epub 2014 Oct 2 doi: 10.1007/s12098-014-1578-1. PMID: 25274444
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320
Matthay KK
J Clin Oncol 1998 Jun;16(6):2003-6. doi: 10.1200/JCO.1998.16.6.2003. PMID: 9626196

Clinical prediction guides

Anand S, Agarwala S, Jain V, Dhua A, Bakhshi S, Jana M, Kandasamy D, Biswas A
Indian J Pediatr 2023 Mar;90(3):220-226. Epub 2022 Sep 16 doi: 10.1007/s12098-022-04341-7. PMID: 36112265
Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Raitio A, Rice MJ, Mullassery D, Losty PD
Eur J Pediatr Surg 2021 Oct;31(5):385-389. Epub 2020 Sep 15 doi: 10.1055/s-0040-1716836. PMID: 32932540
Wang Z, Sun H, Li K, Yao W, Dong K, Ma Y, Zheng S
J Pediatr Surg 2019 Dec;54(12):2585-2588. Epub 2019 Aug 30 doi: 10.1016/j.jpedsurg.2019.08.031. PMID: 31521373
Tsubota S, Kadomatsu K
Cell Tissue Res 2018 May;372(2):211-221. Epub 2018 Feb 14 doi: 10.1007/s00441-018-2796-z. PMID: 29445860

Recent systematic reviews

Raitio A, Rice MJ, Mullassery D, Losty PD
Eur J Pediatr Surg 2021 Oct;31(5):385-389. Epub 2020 Sep 15 doi: 10.1055/s-0040-1716836. PMID: 32932540

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