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Stage 4 Neuroblastoma

MedGen UID:
78866
Concept ID:
C0278694
Neoplastic Process
Synonyms: Disseminated Neuroblastoma; Metastatic neuroblastoma; Stage IV Neuroblastoma
SNOMED CT: Metastatic neuroblastoma (704152002)

Definition

Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs, except as defined for stage 4S. (cancer.gov) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Berthold F, Hero B
Drugs 2000 Jun;59(6):1261-77. doi: 10.2165/00003495-200059060-00006. PMID: 10882162
Klingebiel T, Bader P, Bares R, Beck J, Hero B, Jürgens H, Lang P, Niethammer D, Rath B, Handgretinger R
Eur J Cancer 1998 Aug;34(9):1398-402. doi: 10.1016/s0959-8049(98)00130-0. PMID: 9849423

Recent clinical studies

Etiology

Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R
Eur J Cancer 2021 Feb;144:1-8. Epub 2020 Dec 11 doi: 10.1016/j.ejca.2020.10.020. PMID: 33316634
Tas ML, Reedijk AMJ, Karim-Kos HE, Kremer LCM, van de Ven CP, Dierselhuis MP, van Eijkelenburg NKA, van Grotel M, Kraal KCJM, Peek AML, Coebergh JWW, Janssens GOR, de Keizer B, de Krijger RR, Pieters R, Tytgat GAM, van Noesel MM
Eur J Cancer 2020 Jan;124:47-55. Epub 2019 Nov 11 doi: 10.1016/j.ejca.2019.09.025. PMID: 31726247
Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN
Lancet Oncol 2018 Dec;19(12):1617-1629. Epub 2018 Nov 12 doi: 10.1016/S1470-2045(18)30578-3. PMID: 30442501
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Perwein T, Lackner H, Sovinz P, Benesch M, Schmidt S, Schwinger W, Urban C
Pediatr Blood Cancer 2011 Oct;57(4):629-35. Epub 2011 Feb 11 doi: 10.1002/pbc.23036. PMID: 21319289

Diagnosis

Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R
Eur J Cancer 2021 Feb;144:1-8. Epub 2020 Dec 11 doi: 10.1016/j.ejca.2020.10.020. PMID: 33316634
Tas ML, Reedijk AMJ, Karim-Kos HE, Kremer LCM, van de Ven CP, Dierselhuis MP, van Eijkelenburg NKA, van Grotel M, Kraal KCJM, Peek AML, Coebergh JWW, Janssens GOR, de Keizer B, de Krijger RR, Pieters R, Tytgat GAM, van Noesel MM
Eur J Cancer 2020 Jan;124:47-55. Epub 2019 Nov 11 doi: 10.1016/j.ejca.2019.09.025. PMID: 31726247
Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN
Lancet Oncol 2018 Dec;19(12):1617-1629. Epub 2018 Nov 12 doi: 10.1016/S1470-2045(18)30578-3. PMID: 30442501
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Perwein T, Lackner H, Sovinz P, Benesch M, Schmidt S, Schwinger W, Urban C
Pediatr Blood Cancer 2011 Oct;57(4):629-35. Epub 2011 Feb 11 doi: 10.1002/pbc.23036. PMID: 21319289

Therapy

Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R
Eur J Cancer 2021 Feb;144:1-8. Epub 2020 Dec 11 doi: 10.1016/j.ejca.2020.10.020. PMID: 33316634
Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN
Lancet Oncol 2018 Dec;19(12):1617-1629. Epub 2018 Nov 12 doi: 10.1016/S1470-2045(18)30578-3. PMID: 30442501
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Mullassery D, Farrelly P, Losty PD
Pediatr Hematol Oncol 2014 Nov;31(8):703-16. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.947009. PMID: 25247398
Perwein T, Lackner H, Sovinz P, Benesch M, Schmidt S, Schwinger W, Urban C
Pediatr Blood Cancer 2011 Oct;57(4):629-35. Epub 2011 Feb 11 doi: 10.1002/pbc.23036. PMID: 21319289

Prognosis

Sezgin G, Görüroğlu Öztürk Ö, Özkan A, Küpeli S, Bayram İ
Med Princ Pract 2022;31(6):532-539. Epub 2022 May 10 doi: 10.1159/000524656. PMID: 35537400Free PMC Article
Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R
Eur J Cancer 2021 Feb;144:1-8. Epub 2020 Dec 11 doi: 10.1016/j.ejca.2020.10.020. PMID: 33316634
Tas ML, Reedijk AMJ, Karim-Kos HE, Kremer LCM, van de Ven CP, Dierselhuis MP, van Eijkelenburg NKA, van Grotel M, Kraal KCJM, Peek AML, Coebergh JWW, Janssens GOR, de Keizer B, de Krijger RR, Pieters R, Tytgat GAM, van Noesel MM
Eur J Cancer 2020 Jan;124:47-55. Epub 2019 Nov 11 doi: 10.1016/j.ejca.2019.09.025. PMID: 31726247
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Perwein T, Lackner H, Sovinz P, Benesch M, Schmidt S, Schwinger W, Urban C
Pediatr Blood Cancer 2011 Oct;57(4):629-35. Epub 2011 Feb 11 doi: 10.1002/pbc.23036. PMID: 21319289

Clinical prediction guides

Li Y, Feng C, Chen Y, Huang K, Li C, Xiong X, Li P, Zhou D, Peng X, Weng W, Deng X, Wu Y, Fang J
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211041454. doi: 10.1177/15330338211041454. PMID: 34569870Free PMC Article
Daudigeos-Dubus E, LE Dret L, Rouffiac V, Bawa O, Leguerney I, Opolon P, Vassal G, Geoerger B
In Vivo 2014 Jul-Aug;28(4):425-34. PMID: 24982206
Viprey VF, Gregory WM, Corrias MV, Tchirkov A, Swerts K, Vicha A, Dallorso S, Brock P, Luksch R, Valteau-Couanet D, Papadakis V, Laureys G, Pearson AD, Ladenstein R, Burchill SA
J Clin Oncol 2014 Apr 1;32(10):1074-83. Epub 2014 Mar 3 doi: 10.1200/JCO.2013.53.3604. PMID: 24590653
Banelli B, Merlo DF, Allemanni G, Forlani A, Romani M
PLoS One 2013;8(5):e63253. Epub 2013 May 22 doi: 10.1371/journal.pone.0063253. PMID: 23717404Free PMC Article
Perwein T, Lackner H, Sovinz P, Benesch M, Schmidt S, Schwinger W, Urban C
Pediatr Blood Cancer 2011 Oct;57(4):629-35. Epub 2011 Feb 11 doi: 10.1002/pbc.23036. PMID: 21319289

Recent systematic reviews

Mullassery D, Farrelly P, Losty PD
Pediatr Hematol Oncol 2014 Nov;31(8):703-16. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.947009. PMID: 25247398

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