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Sarcomatoid renal cell carcinoma

MedGen UID:
220411
•Concept ID:
C1266043
•
Neoplastic Process
Synonym: Sarcomatoid Renal Cell Carcinoma
SNOMED CT: Renal cell carcinoma, spindle cell (128668003); Renal cell carcinoma, sarcomatoid (128668003)
 
Monarch Initiative: MONDO:0003012

Definition

A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcomatoid renal cell carcinoma

Professional guidelines

PubMed

Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma.
Tannir NM, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, Flaifel A, Pignon JC, Ficial M, Frontera OA, George S, Powles T, Donskov F, Harrison MR, Barthélémy P, Tykodi SS, Kocsis J, Ravaud A, Rodriguez-Cid JR, Pal SK, Murad AM, Ishii Y, Saggi SS, McHenry MB, Rini BI
Clin Cancer Res 2021 Jan 1;27(1):78-86. Epub 2020 Sep 1 doi: 10.1158/1078-0432.CCR-20-2063. PMID: 32873572Free PMC Article
Sarcomatoid renal cell carcinoma: biology, natural history and management.
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Sarcomatoid renal cell carcinoma: Biology and treatment advances.
Mouallem NE, Smith SC, Paul AK
Urol Oncol 2018 Jun;36(6):265-271. Epub 2018 Jan 3 doi: 10.1016/j.urolonc.2017.12.012. PMID: 29306556

Recent clinical studies

Etiology

Sarcomatoid renal cell carcinoma: MRI features and their association with survival.
Cheng M, Duzgol C, Kim TH, Ghafoor S, Becker AS, Causa Andrieu PI, Gangai N, Jiang H, Hakimi AA, Vargas HA, Woo S
Cancer Imaging 2023 Feb 15;23(1):16. doi: 10.1186/s40644-023-00535-0. PMID: 36793052Free PMC Article
Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Multiregion sequencing of sarcomatoid renal cell carcinoma arising from autosomal dominant polycystic kidney disease.
Lee E, Guan P, Lim AH, Loh JW, Tan GF, Loh T, Ng DYX, Lee JY, Goh S, Liu W, Ng CC, Teh BT, Chan JY
Mol Genet Genomic Med 2022 Mar;10(3):e1853. Epub 2022 Feb 5 doi: 10.1002/mgg3.1853. PMID: 35122417Free PMC Article
Immunotherapy in metastatic sarcomatoid renal cell carcinoma: A single institution experience.
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS
Cancer Treat Res Commun 2020;25:100251. Epub 2020 Nov 23 doi: 10.1016/j.ctarc.2020.100251. PMID: 33310369
Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients.
Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ
Clin Genitourin Cancer 2019 Jun;17(3):e447-e453. Epub 2019 Jan 17 doi: 10.1016/j.clgc.2019.01.005. PMID: 30799129

Diagnosis

Sarcomatoid renal cell carcinoma: biology, natural history and management.
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Renal cell carcinomas with a mesenchymal stromal component: what do we know so far?
Williamson SR
Pathology 2019 Aug;51(5):453-462. Epub 2019 Jun 29 doi: 10.1016/j.pathol.2019.04.006. PMID: 31266596
Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients.
Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ
Clin Genitourin Cancer 2019 Jun;17(3):e447-e453. Epub 2019 Jan 17 doi: 10.1016/j.clgc.2019.01.005. PMID: 30799129
Sarcomatoid renal cell carcinoma: a case report and literature review.
Liang X, Liu Y, Ran P, Tang M, Xu C, Zhu Y
BMC Nephrol 2018 Apr 10;19(1):84. doi: 10.1186/s12882-018-0884-7. PMID: 29636020Free PMC Article
Xanthogranulomatous pyelonephritis.
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966

Therapy

Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Immunotherapy in metastatic sarcomatoid renal cell carcinoma: A single institution experience.
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS
Cancer Treat Res Commun 2020;25:100251. Epub 2020 Nov 23 doi: 10.1016/j.ctarc.2020.100251. PMID: 33310369
Sarcomatoid renal cell carcinoma: biology, natural history and management.
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Systemic therapy for sarcomatoid renal cell carcinoma.
Pagliaro LC, Tannir N, Sircar K, Jonasch E
Expert Rev Anticancer Ther 2011 Jun;11(6):913-20. doi: 10.1586/era.11.39. PMID: 21707288
Xanthogranulomatous pyelonephritis.
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966

Prognosis

Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Sarcomatoid renal cell carcinoma: biology, natural history and management.
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients.
Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ
Clin Genitourin Cancer 2019 Jun;17(3):e447-e453. Epub 2019 Jan 17 doi: 10.1016/j.clgc.2019.01.005. PMID: 30799129
Sarcomatoid renal cell carcinoma: Biology and treatment advances.
Mouallem NE, Smith SC, Paul AK
Urol Oncol 2018 Jun;36(6):265-271. Epub 2018 Jan 3 doi: 10.1016/j.urolonc.2017.12.012. PMID: 29306556
Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies.
Shuch B, Bratslavsky G, Linehan WM, Srinivasan R
Oncologist 2012;17(1):46-54. Epub 2012 Jan 10 doi: 10.1634/theoncologist.2011-0227. PMID: 22234634Free PMC Article

Clinical prediction guides

Multiregion sequencing of sarcomatoid renal cell carcinoma arising from autosomal dominant polycystic kidney disease.
Lee E, Guan P, Lim AH, Loh JW, Tan GF, Loh T, Ng DYX, Lee JY, Goh S, Liu W, Ng CC, Teh BT, Chan JY
Mol Genet Genomic Med 2022 Mar;10(3):e1853. Epub 2022 Feb 5 doi: 10.1002/mgg3.1853. PMID: 35122417Free PMC Article
Micro-RNA378a-3p Induces Apoptosis in Sarcomatoid Renal Cell Carcinoma and Regulates POLR2A and RUNX2 Expression.
Weng WH, Yu KJ, Jhan JW, Pang SN, Chiou YE, Pang ST
Anticancer Res 2022 Feb;42(2):811-825. doi: 10.21873/anticanres.15539. PMID: 35093879
Can we identify a preferred first-line strategy for sarcomatoid renal cell carcinoma? A network meta-analysis.
Buti S, Bersanelli M, Mazzaschi G, Cattrini C, Brunelli M, Di Maio M
Immunotherapy 2022 Feb;14(2):145-153. Epub 2021 Nov 22 doi: 10.2217/imt-2021-0157. PMID: 34806404
Efficacy and correlative analyses of avelumab plus axitinib versus sunitinib in sarcomatoid renal cell carcinoma: post hoc analysis of a randomized clinical trial.
Choueiri TK, Larkin J, Pal S, Motzer RJ, Rini BI, Venugopal B, Alekseev B, Miyake H, Gravis G, Bilen MA, Hariharan S, Chudnovsky A, Ching KA, Mu XJ, Mariani M, Robbins PB, Huang B, di Pietro A, Albiges L
ESMO Open 2021 Jun;6(3):100101. Epub 2021 Apr 23 doi: 10.1016/j.esmoop.2021.100101. PMID: 33901870Free PMC Article
Sarcomatoid renal cell carcinoma: clinical outcome and survival after treatment with sunitinib.
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086

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