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Thyroid gland spindle cell tumor with thymus-like differentiation

MedGen UID:
220415
•Concept ID:
C1266099
•
Neoplastic Process
Synonyms: settle; SETTLE - spindle epithelial tumor with thymus-like element; settle tumor; settle tumour; Spindle epithelial tumor with thymus-like differentiation; spindle epithelial tumor with thymus-like differentiation tumor; Spindle epithelial tumor with thymus-like element; Spindle Epithelial Tumor with Thymus-Like Elements; spindle epithelial tumour with thymus-like differentiation tumour; Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation; thyroid gland spindle cell tumor with thymus-like differentiation; Thyroid Gland Spindle Epithelial Tumor with Thymus-Like Elements
SNOMED CT: Spindle epithelial tumor with thymus-like differentiation (128719006); Spindle epithelial tumor with thymus-like element (128719006); SETTLE - spindle epithelial tumor with thymus-like element (128719006)
 
Monarch Initiative: MONDO:0006466

Definition

A rare, slow growing malignant tumor of the thyroid gland arising from intrathyroidal thymic tissue. It is characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells. A small number of cases are composed exclusively of spindle epithelial cells or glandular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland spindle cell tumor with thymus-like differentiation

Professional guidelines

PubMed

Spindle epithelial tumor with thymus-like differentiation (SETTLE): clinical-pathological features, differential pathological diagnosis and therapy.
Ippolito S, Bellevicine C, Arpaia D, Peirce C, Ciancia G, Vigliar E, Troncone G, Biondi B
Endocrine 2016 Mar;51(3):402-12. Epub 2015 Aug 20 doi: 10.1007/s12020-015-0716-5. PMID: 26289127

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Carcinoma showing thymus-like differentiation of the thyroid (CASTLE).
Huang C, Wang L, Wang Y, Yang X, Li Q
Pathol Res Pract 2013 Oct;209(10):662-5. Epub 2013 Jul 15 doi: 10.1016/j.prp.2013.06.021. PMID: 23920320
Spindle epithelial tumor with thymus-like differentiation: a case report and review of literature.
Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid.
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y
Head Neck 2002 Sep;24(9):888-93. doi: 10.1002/hed.10111. PMID: 12211053
Solitary fibrous tumor of the thyroid gland: report of seven cases.
Rodriguez I, Ayala E, Caballero C, De Miguel C, Matias-Guiu X, Cubilla AL, Rosai J
Am J Surg Pathol 2001 Nov;25(11):1424-8. doi: 10.1097/00000478-200111000-00011. PMID: 11684960

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Spindle epithelial tumor with thymus-like differentiation (SETTLE): clinical-pathological features, differential pathological diagnosis and therapy.
Ippolito S, Bellevicine C, Arpaia D, Peirce C, Ciancia G, Vigliar E, Troncone G, Biondi B
Endocrine 2016 Mar;51(3):402-12. Epub 2015 Aug 20 doi: 10.1007/s12020-015-0716-5. PMID: 26289127
Spindle epithelial tumor with thymus-like differentiation: a case report and review of literature.
Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review.
Magnata Filho LA, Bordallo MA, Pessoa CH, Corbo R, Bulzico DA, Dias FL, Machado AL, Soares AB, Ferman S
Arq Bras Endocrinol Metabol 2010 Oct;54(7):657-62. doi: 10.1590/s0004-27302010000700011. PMID: 21085772
Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid.
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y
Head Neck 2002 Sep;24(9):888-93. doi: 10.1002/hed.10111. PMID: 12211053

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Spindle epithelial tumor with thymus-like differentiation (SETTLE): clinical-pathological features, differential pathological diagnosis and therapy.
Ippolito S, Bellevicine C, Arpaia D, Peirce C, Ciancia G, Vigliar E, Troncone G, Biondi B
Endocrine 2016 Mar;51(3):402-12. Epub 2015 Aug 20 doi: 10.1007/s12020-015-0716-5. PMID: 26289127
Spindle epithelial tumor with thymus-like differentiation: a case report and review of literature.
Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Primary spindle cell lesions of the thyroid gland; an overview.
Papi G, Corrado S, LiVolsi VA
Am J Clin Pathol 2006 Jun;125 Suppl:S95-123. doi: 10.1309/4DQW6RQX3C6KRX1J. PMID: 16830961
Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid.
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y
Head Neck 2002 Sep;24(9):888-93. doi: 10.1002/hed.10111. PMID: 12211053

Clinical prediction guides

Spindle epithelial tumor with thymus-like differentiation: a case report and review of literature.
Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Fine-needle aspiration in the evaluation of thyroid lesions in children.
Kaur J, Srinivasan R, Arora SK, Rajwanshi A, Saikia UN, Dutta P, Gupta N, Nijhawan R, Dey P
Diagn Cytopathol 2012 May;40 Suppl 1:E33-7. Epub 2010 Oct 26 doi: 10.1002/dc.21568. PMID: 22619157
Spindle epithelial tumor with thymus-like differentiation of the thyroid: a case report with pathological and molecular genetics study.
Xu B, Hirokawa M, Yoshimoto K, Miki H, Takahashi M, Kuma S, Sano T
Hum Pathol 2003 Feb;34(2):190-3. doi: 10.1053/hupa.2003.29. PMID: 12612889
Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): is cytopathological diagnosis possible?
Kloboves-Prevodnik V, Jazbec J, Us-Krasovec M, Lamovec J
Diagn Cytopathol 2002 May;26(5):314-9. doi: 10.1002/dc.10107. PMID: 11992375

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