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Thyroid gland spindle cell tumor with thymus-like differentiation

MedGen UID:
220415
Concept ID:
C1266099
Neoplastic Process
Synonyms: settle; SETTLE - spindle epithelial tumor with thymus-like element; settle tumor; settle tumour; Spindle epithelial tumor with thymus-like differentiation; spindle epithelial tumor with thymus-like differentiation tumor; Spindle epithelial tumor with thymus-like element; Spindle Epithelial Tumor with Thymus-Like Elements; spindle epithelial tumour with thymus-like differentiation tumour; Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation; thyroid gland spindle cell tumor with thymus-like differentiation; Thyroid Gland Spindle Epithelial Tumor with Thymus-Like Elements
SNOMED CT: Spindle epithelial tumor with thymus-like differentiation (128719006); Spindle epithelial tumor with thymus-like element (128719006); SETTLE - spindle epithelial tumor with thymus-like element (128719006)
 
Monarch Initiative: MONDO:0006466

Definition

A rare, slow growing malignant tumor of the thyroid gland arising from intrathyroidal thymic tissue. It is characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells. A small number of cases are composed exclusively of spindle epithelial cells or glandular cells. [from NCI]

Professional guidelines

PubMed

Ippolito S, Bellevicine C, Arpaia D, Peirce C, Ciancia G, Vigliar E, Troncone G, Biondi B
Endocrine 2016 Mar;51(3):402-12. Epub 2015 Aug 20 doi: 10.1007/s12020-015-0716-5. PMID: 26289127

Recent clinical studies

Etiology

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Huang C, Wang L, Wang Y, Yang X, Li Q
Pathol Res Pract 2013 Oct;209(10):662-5. Epub 2013 Jul 15 doi: 10.1016/j.prp.2013.06.021. PMID: 23920320
Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y
Head Neck 2002 Sep;24(9):888-93. doi: 10.1002/hed.10111. PMID: 12211053
Kloboves-Prevodnik V, Jazbec J, Us-Krasovec M, Lamovec J
Diagn Cytopathol 2002 May;26(5):314-9. doi: 10.1002/dc.10107. PMID: 11992375

Diagnosis

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Adegun OK, Proctor I, Falzon M, Pomplun S
Diagn Cytopathol 2021 Aug;49(8):E325-E328. Epub 2021 Apr 1 doi: 10.1002/dc.24744. PMID: 33794064
Ippolito S, Bellevicine C, Arpaia D, Peirce C, Ciancia G, Vigliar E, Troncone G, Biondi B
Endocrine 2016 Mar;51(3):402-12. Epub 2015 Aug 20 doi: 10.1007/s12020-015-0716-5. PMID: 26289127
Magnata Filho LA, Bordallo MA, Pessoa CH, Corbo R, Bulzico DA, Dias FL, Machado AL, Soares AB, Ferman S
Arq Bras Endocrinol Metabol 2010 Oct;54(7):657-62. doi: 10.1590/s0004-27302010000700011. PMID: 21085772
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y
Head Neck 2002 Sep;24(9):888-93. doi: 10.1002/hed.10111. PMID: 12211053

Prognosis

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Ippolito S, Bellevicine C, Arpaia D, Peirce C, Ciancia G, Vigliar E, Troncone G, Biondi B
Endocrine 2016 Mar;51(3):402-12. Epub 2015 Aug 20 doi: 10.1007/s12020-015-0716-5. PMID: 26289127
Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Papi G, Corrado S, LiVolsi VA
Am J Clin Pathol 2006 Jun;125 Suppl:S95-123. doi: 10.1309/4DQW6RQX3C6KRX1J. PMID: 16830961
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y
Head Neck 2002 Sep;24(9):888-93. doi: 10.1002/hed.10111. PMID: 12211053

Clinical prediction guides

Misra RK, Mitra S, Yadav R, Bundela A
Acta Cytol 2013;57(3):303-8. Epub 2013 Apr 25 doi: 10.1159/000346704. PMID: 23635450
Kaur J, Srinivasan R, Arora SK, Rajwanshi A, Saikia UN, Dutta P, Gupta N, Nijhawan R, Dey P
Diagn Cytopathol 2012 May;40 Suppl 1:E33-7. Epub 2010 Oct 26 doi: 10.1002/dc.21568. PMID: 22619157
Xu B, Hirokawa M, Yoshimoto K, Miki H, Takahashi M, Kuma S, Sano T
Hum Pathol 2003 Feb;34(2):190-3. doi: 10.1053/hupa.2003.29. PMID: 12612889
Kloboves-Prevodnik V, Jazbec J, Us-Krasovec M, Lamovec J
Diagn Cytopathol 2002 May;26(5):314-9. doi: 10.1002/dc.10107. PMID: 11992375

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