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Malignant Somatostatinoma

MedGen UID:
224755
•Concept ID:
C1266015
•
Neoplastic Process
Synonyms: Delta Cell Carcinoma; Somatostatin cell tumor, malignant; Somatostatinoma, malignant
SNOMED CT: Somatostatin cell tumor, malignant (128643000); Somatostatinoma, malignant (128643000)

Definition

A neuroendocrine tumor arising from delta cells which produce somatostatin. It displays vascular invasion and metastasizes to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Diabetes Mellitus Secondary to Endocrine Diseases: An Update of Diagnostic and Treatment Particularities.
Popoviciu MS, Paduraru L, Nutas RM, Ujoc AM, Yahya G, Metwally K, Cavalu S
Int J Mol Sci 2023 Aug 11;24(16) doi: 10.3390/ijms241612676. PMID: 37628857Free PMC Article
Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266
Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Recent clinical studies

Therapy

Carcinoid syndrome due to a malignant somatostatinoma.
Ozbakir O, Keleştimur F, Oztürk F, Sözüer E, Unal A, Patiroğlu TE, Güven K
Postgrad Med J 1995 Nov;71(841):695-8. doi: 10.1136/pgmj.71.841.695. PMID: 7494779Free PMC Article
Malignant pancreatic somatostatinoma in a patient with dermatitis herpetiformis and coeliac disease.
Levi S, Bjarnason I, Swinson CM, Polak JM, Murray W, Levi AJ
Digestion 1988;39(1):1-6. doi: 10.1159/000199601. PMID: 2899527

Prognosis

Atypical thymic carcinoid and malignant somatostatinoma in type I multiple endocrine neoplasia syndrome: case report.
Lin FC, Lin CM, Hsieh CC, Li WY, Wang LS
Am J Clin Oncol 2003 Jun;26(3):270-2. doi: 10.1097/01.COC.0000020584.56294.72. PMID: 12796599

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