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Somatostatinoma

MedGen UID:
52416
Concept ID:
C0037661
Neoplastic Process
Synonyms: Ampullary somatostatinoma; Carcinoid somatostatinoma; Malignant islet cell tumor; Somatomedin-secreting carcinoid; Somatostatin-secreting pancreatic neoplasm
SNOMED CT: Somatostatin cell tumor (128642005); Somatostatinoma (128642005); Delta cell tumor (253006001); Somatostatinoma (253006001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0006976
Orphanet: ORPHA97283

Definition

Somatostatinoma (SSoma) is an extremely rare pancreatic neuroendocrine tumor or duodenal endocrine tumor (see these terms) that originates either in the pancreas (50%) or the gastrointestinal tract (50%) and mainly presents with non-specific symptoms of abdominal pain, weight loss, jaundice and diarrhea but, in approximately 20% of pancreatic cases, leads to a somatostatin hypersecretion syndrome (somatostatinoma syndrome) characterized by diabetes mellitus, cholelithiasis, steatorrhea and hypochlorhydria. [from ORDO]

Professional guidelines

PubMed

Popoviciu MS, Paduraru L, Nutas RM, Ujoc AM, Yahya G, Metwally K, Cavalu S
Int J Mol Sci 2023 Aug 11;24(16) doi: 10.3390/ijms241612676. PMID: 37628857Free PMC Article
Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266
Virgolini I, Traub-Weidinger T, Decristoforo C
Best Pract Res Clin Endocrinol Metab 2005 Jun;19(2):213-27. doi: 10.1016/j.beem.2004.09.001. PMID: 15763696

Recent clinical studies

Etiology

Popoviciu MS, Paduraru L, Nutas RM, Ujoc AM, Yahya G, Metwally K, Cavalu S
Int J Mol Sci 2023 Aug 11;24(16) doi: 10.3390/ijms241612676. PMID: 37628857Free PMC Article
Lam AK, Ishida H
Histol Histopathol 2021 Apr;36(4):367-382. Epub 2020 Dec 11 doi: 10.14670/HH-18-288. PMID: 33305819
de Herder WW, Rehfeld JF, Kidd M, Modlin IM
Best Pract Res Clin Endocrinol Metab 2016 Jan;30(1):3-17. Epub 2015 Oct 23 doi: 10.1016/j.beem.2015.10.004. PMID: 26971840
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Hoffmann KM, Furukawa M, Jensen RT
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):675-97. doi: 10.1016/j.bpg.2005.05.009. PMID: 16253893

Diagnosis

Hofland J, Falconi M, Christ E, Castaño JP, Faggiano A, Lamarca A, Perren A, Petrucci S, Prasad V, Ruszniewski P, Thirlwell C, Vullierme MP, Welin S, Bartsch DK
J Neuroendocrinol 2023 Aug;35(8):e13318. Epub 2023 Aug 14 doi: 10.1111/jne.13318. PMID: 37578384
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Batcher E, Madaj P, Gianoukakis AG
Endocr Res 2011;36(1):35-43. doi: 10.3109/07435800.2010.525085. PMID: 21226566
de Herder WW
Best Pract Res Clin Endocrinol Metab 2007 Mar;21(1):33-41. doi: 10.1016/j.beem.2006.12.002. PMID: 17382264
Vinik AI, Strodel WE, Eckhauser FE, Moattari AR, Lloyd R
Semin Oncol 1987 Sep;14(3):263-81. PMID: 2820062

Therapy

Yu R, Rao J, Zhai J, Hecht JR, Pisegna JR
Pancreas 2022 Sep 1;51(8):1056-1060. doi: 10.1097/MPA.0000000000002126. PMID: 36607953
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Resmini E, Minuto F, Colao A, Ferone D
Acta Diabetol 2009 Jun;46(2):85-95. Epub 2009 Mar 26 doi: 10.1007/s00592-009-0112-9. PMID: 19322513
Gorden P, Comi RJ, Maton PN, Go VL
Ann Intern Med 1989 Jan 1;110(1):35-50. doi: 10.7326/0003-4819-110-1-35. PMID: 2535688
Lamers CB
Acta Endocrinol Suppl (Copenh) 1987;286:19-25. doi: 10.1530/acta.0.115s019. PMID: 2892334

Prognosis

Lam AK, Ishida H
Histol Histopathol 2021 Apr;36(4):367-382. Epub 2020 Dec 11 doi: 10.14670/HH-18-288. PMID: 33305819
Kanakis G, Kaltsas G
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):791-802. doi: 10.1016/j.bpg.2012.12.006. PMID: 23582919
Morgan KA, Adams DB
Surg Clin North Am 2010 Apr;90(2):287-307. doi: 10.1016/j.suc.2009.12.009. PMID: 20362787
Hoffmann KM, Furukawa M, Jensen RT
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):675-97. doi: 10.1016/j.bpg.2005.05.009. PMID: 16253893
Soldati T, Del Noce G, Garino M, Farina EC, De Paolis P, Balbo G
Panminerva Med 1990 Jul-Sep;32(3):141-4. PMID: 2077482

Clinical prediction guides

Karaghiannis V, Maric D, Garrec C, Maaziz N, Buffet A, Schmitt L, Antunes V, Airaud F, Aral B, Le Roy A, Corbineau S, Mansour-Hendili L, Lesieur V, Rimbert A, Laporte F, Delamare M, Rab M, Bézieau S, Cassinat B, Galacteros F, Gimenez-Roqueplo AP, Burnichon N, Cario H, Van Wijk R, Bento C, Girodon F, Hoogewijs D, Gardie B
Haematologica 2023 Jun 1;108(6):1652-1666. doi: 10.3324/haematol.2022.281698. PMID: 36700397Free PMC Article
Dwight T, Kim E, Bastard K, Benn DE, Eisenhofer G, Richter S, Mannelli M, Rapizzi E, Prejbisz A, Pęczkowska M, Pacak K, Clifton-Bligh R
Endocr Relat Cancer 2021 Feb;28(2):97-109. doi: 10.1530/ERC-20-0280. PMID: 33300499Free PMC Article
Kanakis G, Kaltsas G
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):791-802. doi: 10.1016/j.bpg.2012.12.006. PMID: 23582919
Resmini E, Minuto F, Colao A, Ferone D
Acta Diabetol 2009 Jun;46(2):85-95. Epub 2009 Mar 26 doi: 10.1007/s00592-009-0112-9. PMID: 19322513
Azimuddin K, Chamberlain RS
Surg Clin North Am 2001 Jun;81(3):511-25. doi: 10.1016/s0039-6109(05)70140-7. PMID: 11459268

Recent systematic reviews

Giannakodimos I, Giannakodimos A, Ziogou A, Frountzas M, Kritikos N, Vlachos K, Toutouzas KG, Schizas D
J Gastrointestin Liver Dis 2022 Dec 17;31(4):459-466. doi: 10.15403/jgld-4383. PMID: 36535044

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