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Genital Rhabdomyoma

MedGen UID:
224765
•Concept ID:
C1266133
•
Neoplastic Process
Synonyms: Genital rhabdomyoma; Genital type rhabdomyoma
SNOMED CT: Genital rhabdomyoma (404050001); Genital rhabdomyoma (128748000); Genital type rhabdomyoma (128748000)

Definition

A rare benign skeletal muscle neoplasm arising from the female genital tract. It is characterized by the presence of small nucleated rhabdomyoblasts within a fibrous and myxoid stroma. [from NCI]

Recent clinical studies

Etiology

Molecular assessment of paratesticular rhabdomyomas demonstrates recurrent findings, including a novel H3C2 p.K37I mutation.
Acosta AM, McKenney JK, Sholl LM, Dickson BC, Matoso A, Lu H, Jo VY, Collins K, Ulbright TM, Fletcher CDM
Mod Pathol 2022 Dec;35(12):1921-1928. Epub 2022 Jul 16 doi: 10.1038/s41379-022-01134-3. PMID: 35842480

Diagnosis

Molecular assessment of paratesticular rhabdomyomas demonstrates recurrent findings, including a novel H3C2 p.K37I mutation.
Acosta AM, McKenney JK, Sholl LM, Dickson BC, Matoso A, Lu H, Jo VY, Collins K, Ulbright TM, Fletcher CDM
Mod Pathol 2022 Dec;35(12):1921-1928. Epub 2022 Jul 16 doi: 10.1038/s41379-022-01134-3. PMID: 35842480
Cervical rhabdomyoma a rare entity: Case report with review of literature.
Sagar N, Mandal S, Khurana N, Kumar A
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):467-469. doi: 10.4103/IJPM.IJPM_73_19. PMID: 32769342
Ovarian serous cystadenoma with mural nodules of genital rhabdomyoma.
Huang TY, Chen JT, Ho WL
Hum Pathol 2005 Apr;36(4):433-5. doi: 10.1016/j.humpath.2005.01.003. PMID: 15892006
Epididymal rhabdomyoma: report of a case, including histologic and immunohistochemical findings.
Wehner MS, Humphreys JL, Sharkey FE
Arch Pathol Lab Med 2000 Oct;124(10):1518-9. doi: 10.5858/2000-124-1518-ER. PMID: 11035587
Rhabdomyoma of the tunica vaginalis of the testis: a histologic, immunohistochemical, and ultrastructural study.
Tanda F, Rocca PC, Bosincu L, Massarelli G, Cossu A, Manca A
Mod Pathol 1997 Jun;10(6):608-11. PMID: 9195580

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