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Ulcerative

MedGen UID:
22541
•Concept ID:
C0041582
•
Pathologic Function
Synonyms: Ulcer; Ulcers
SNOMED CT: Ulcer - lesion (56208002); Ulcer (429040005); Ulcerative (255321001); Ulcer (56208002); Ulceration (56208002); Ulcerative lesion (56208002); Ulcus (56208002)

Definition

A circumscribed inflammatory and often suppurating lesion on the skin or an internal mucous surface resulting in necrosis of tissue. [from NCI]

Professional guidelines

PubMed

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease.
Seyedian SS, Nokhostin F, Malamir MD
J Med Life 2019 Apr-Jun;12(2):113-122. doi: 10.25122/jml-2018-0075. PMID: 31406511Free PMC Article

Recent clinical studies

Etiology

Nutrition and Supplementation in Ulcerative Colitis.
Radziszewska M, Smarkusz-Zarzecka J, Ostrowska L, Pogodziński D
Nutrients 2022 Jun 14;14(12) doi: 10.3390/nu14122469. PMID: 35745199Free PMC Article
Morphology of inflammatory bowel diseases (IBD).
Fabián O, Kamaradová K
Cesk Patol 2022 Spring;58(1):27-37. PMID: 35387455
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
Epidemiology and Pathogenesis of Ulcerative Colitis.
Du L, Ha C
Gastroenterol Clin North Am 2020 Dec;49(4):643-654. Epub 2020 Sep 25 doi: 10.1016/j.gtc.2020.07.005. PMID: 33121686
Diet in the Pathogenesis and Management of Ulcerative Colitis; A Review of Randomized Controlled Dietary Interventions.
Keshteli AH, Madsen KL, Dieleman LA
Nutrients 2019 Jun 30;11(7) doi: 10.3390/nu11071498. PMID: 31262022Free PMC Article

Diagnosis

Ulcerative Colitis: Rapid Evidence Review.
Adams SM, Close ED, Shreenath AP
Am Fam Physician 2022 Apr 1;105(4):406-411. PMID: 35426646
Ulcerative colitis: an update.
Segal JP, LeBlanc JF, Hart AL
Clin Med (Lond) 2021 Mar;21(2):135-139. doi: 10.7861/clinmed.2021-0080. PMID: 33762374Free PMC Article
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
Ulcerative Colitis: Where We Are and Where We Are Not in 2020.
Buchman AL
Gastroenterol Clin North Am 2020 Dec;49(4):xiii-xiv. Epub 2020 Sep 25 doi: 10.1016/j.gtc.2020.09.003. PMID: 33121698
Ulcerative colitis.
Adams SM, Bornemann PH
Am Fam Physician 2013 May 15;87(10):699-705. PMID: 23939448

Therapy

Ozanimod: A Review in Ulcerative Colitis.
Paik J
Drugs 2022 Aug;82(12):1303-1313. Epub 2022 Aug 22 doi: 10.1007/s40265-022-01762-8. PMID: 35994200Free PMC Article
Evaluating Upadacitinib in the Treatment of Moderate-to-Severe Active Ulcerative Colitis: Design, Development, and Potential Position in Therapy.
Napolitano M, D'Amico F, Ragaini E, Peyrin-Biroulet L, Danese S
Drug Des Devel Ther 2022;16:1897-1913. Epub 2022 Jun 17 doi: 10.2147/DDDT.S340459. PMID: 35747444Free PMC Article
Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis.
Sandborn WJ, Feagan BG, D'Haens G, Wolf DC, Jovanovic I, Hanauer SB, Ghosh S, Petersen A, Hua SY, Lee JH, Charles L, Chitkara D, Usiskin K, Colombel JF, Laine L, Danese S; True North Study Group
N Engl J Med 2021 Sep 30;385(14):1280-1291. doi: 10.1056/NEJMoa2033617. PMID: 34587385
The Role of Early Biologic Therapy in Inflammatory Bowel Disease.
Berg DR, Colombel JF, Ungaro R
Inflamm Bowel Dis 2019 Nov 14;25(12):1896-1905. doi: 10.1093/ibd/izz059. PMID: 30934053Free PMC Article
Review of Saccharomyces boulardii as a treatment option in IBD.
Sivananthan K, Petersen AM
Immunopharmacol Immunotoxicol 2018 Dec;40(6):465-475. Epub 2018 May 17 doi: 10.1080/08923973.2018.1469143. PMID: 29771163

Prognosis

The Burden of Inflammatory Bowel Disease in Europe in 2020.
Zhao M, Gönczi L, Lakatos PL, Burisch J
J Crohns Colitis 2021 Sep 25;15(9):1573-1587. doi: 10.1093/ecco-jcc/jjab029. PMID: 33582812
Incidence and Prevalence of Inflammatory Bowel Disease across Asia.
Park J, Cheon JH
Yonsei Med J 2021 Feb;62(2):99-108. doi: 10.3349/ymj.2021.62.2.99. PMID: 33527789Free PMC Article
Epidemiology and Pathogenesis of Ulcerative Colitis.
Du L, Ha C
Gastroenterol Clin North Am 2020 Dec;49(4):643-654. Epub 2020 Sep 25 doi: 10.1016/j.gtc.2020.07.005. PMID: 33121686
Epidemiology and risk factors for IBD.
Ananthakrishnan AN
Nat Rev Gastroenterol Hepatol 2015 Apr;12(4):205-17. Epub 2015 Mar 3 doi: 10.1038/nrgastro.2015.34. PMID: 25732745
Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis.
da Silva BC, Lyra AC, Rocha R, Santana GO
World J Gastroenterol 2014 Jul 28;20(28):9458-67. doi: 10.3748/wjg.v20.i28.9458. PMID: 25071340Free PMC Article

Clinical prediction guides

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Calprotectin: from biomarker to biological function.
Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE
Gut 2021 Oct;70(10):1978-1988. Epub 2021 Jun 18 doi: 10.1136/gutjnl-2021-324855. PMID: 34145045Free PMC Article
Predicting Outcome in Acute Severe Colitis-Controversies in Clinical Practice in 2021.
Gupta V, Mohsen W, Chapman TP, Satsangi J
J Crohns Colitis 2021 Jul 5;15(7):1211-1221. doi: 10.1093/ecco-jcc/jjaa265. PMID: 33388777Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis.
da Silva BC, Lyra AC, Rocha R, Santana GO
World J Gastroenterol 2014 Jul 28;20(28):9458-67. doi: 10.3748/wjg.v20.i28.9458. PMID: 25071340Free PMC Article

Recent systematic reviews

Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review.
Kuenzig ME, Fung SG, Marderfeld L, Mak JWY, Kaplan GG, Ng SC, Wilson DC, Cameron F, Henderson P, Kotze PG, Bhatti J, Fang V, Gerber S, Guay E, Kotteduwa Jayawarden S, Kadota L, Maldonado D F, Osei JA, Sandarage R, Stanton A, Wan M; InsightScope Pediatric IBD Epidemiology Group, Benchimol EI
Gastroenterology 2022 Apr;162(4):1147-1159.e4. Epub 2022 Jan 5 doi: 10.1053/j.gastro.2021.12.282. PMID: 34995526
Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis.
Lasa JS, Olivera PA, Danese S, Peyrin-Biroulet L
Lancet Gastroenterol Hepatol 2022 Feb;7(2):161-170. Epub 2021 Nov 29 doi: 10.1016/S2468-1253(21)00377-0. PMID: 34856198
STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.
Turner D, Ricciuto A, Lewis A, D'Amico F, Dhaliwal J, Griffiths AM, Bettenworth D, Sandborn WJ, Sands BE, Reinisch W, Schölmerich J, Bemelman W, Danese S, Mary JY, Rubin D, Colombel JF, Peyrin-Biroulet L, Dotan I, Abreu MT, Dignass A; International Organization for the Study of IBD
Gastroenterology 2021 Apr;160(5):1570-1583. Epub 2021 Feb 19 doi: 10.1053/j.gastro.2020.12.031. PMID: 33359090
First- and Second-Line Pharmacotherapies for Patients With Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis.
Singh S, Murad MH, Fumery M, Dulai PS, Sandborn WJ
Clin Gastroenterol Hepatol 2020 Sep;18(10):2179-2191.e6. Epub 2020 Jan 13 doi: 10.1016/j.cgh.2020.01.008. PMID: 31945470Free PMC Article
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646

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