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Ulcer disease

MedGen UID:
22541
Concept ID:
C0041582
Pathologic Function
Synonyms: Ulcer; Ulcers
SNOMED CT: Ulcer - lesion (56208002); Ulcer (429040005); Ulcerative (255321001); Ulcer (56208002); Ulceration (56208002); Ulcerative lesion (56208002); Ulcus (56208002)
 
Monarch Initiative: MONDO:0043839

Definition

A circumscribed inflammatory and often suppurating lesion on the skin or an internal mucous surface resulting in necrosis of tissue. [from NCI]

Professional guidelines

PubMed

Kamada T, Satoh K, Itoh T, Ito M, Iwamoto J, Okimoto T, Kanno T, Sugimoto M, Chiba T, Nomura S, Mieda M, Hiraishi H, Yoshino J, Takagi A, Watanabe S, Koike K
J Gastroenterol 2021 Apr;56(4):303-322. Epub 2021 Feb 23 doi: 10.1007/s00535-021-01769-0. PMID: 33620586Free PMC Article
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Recent clinical studies

Etiology

Laucirica I, García Iglesias P, Calvet X
Med Clin (Barc) 2023 Sep 29;161(6):260-266. Epub 2023 Jun 24 doi: 10.1016/j.medcli.2023.05.008. PMID: 37365037
Tai FWD, McAlindon ME
Clin Med (Lond) 2021 Mar;21(2):131-134. doi: 10.7861/clinmed.2021-0039. PMID: 33762373Free PMC Article
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
Narayanan M, Reddy KM, Marsicano E
Mo Med 2018 May-Jun;115(3):219-224. PMID: 30228726Free PMC Article
Yegen BC
Curr Pharm Des 2018;24(18):2034-2040. doi: 10.2174/1381612824666180510092303. PMID: 29745325

Diagnosis

Tuerk E, Doss S, Polsley K
Prim Care 2023 Sep;50(3):351-362. Epub 2023 May 24 doi: 10.1016/j.pop.2023.03.003. PMID: 37516507
Laucirica I, García Iglesias P, Calvet X
Med Clin (Barc) 2023 Sep 29;161(6):260-266. Epub 2023 Jun 24 doi: 10.1016/j.medcli.2023.05.008. PMID: 37365037
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
Kempenich JW, Sirinek KR
Surg Clin North Am 2018 Oct;98(5):933-944. doi: 10.1016/j.suc.2018.06.003. PMID: 30243454
Narayanan M, Reddy KM, Marsicano E
Mo Med 2018 May-Jun;115(3):219-224. PMID: 30228726Free PMC Article

Therapy

Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H, Holland L, Wilson K, Bhala N, Hawkey C, Hochberg M, Hunt R, Laine L, Lanas A, Patrono C, Baigent C
Lancet Gastroenterol Hepatol 2018 Apr;3(4):231-241. Epub 2018 Feb 21 doi: 10.1016/S2468-1253(18)30037-2. PMID: 29475806Free PMC Article
Ford AC, Gurusamy KS, Delaney B, Forman D, Moayyedi P
Cochrane Database Syst Rev 2016 Apr 19;4(4):CD003840. doi: 10.1002/14651858.CD003840.pub5. PMID: 27092708Free PMC Article
Chan FK, Leung WK
Lancet 2002 Sep 21;360(9337):933-41. doi: 10.1016/s0140-6736(02)11030-0. PMID: 12354485
Silberstein SD
Cephalalgia 1998 Sep;18(7):421-35. doi: 10.1046/j.1468-2982.1998.1807421.x. PMID: 9793694
Strum WB
JAMA 1983 Oct 14;250(14):1894-6. PMID: 6312110

Prognosis

Wang A, Yerxa J, Agarwal S, Turner MC, Schroder V, Youngwirth LM, Lagoo-Deenadayalan S, Pappas TN
Curr Probl Surg 2020 Feb;57(2):100728. Epub 2020 Jan 7 doi: 10.1016/j.cpsurg.2019.100728. PMID: 32138833
Ofori-Adjei D
Ghana Med J 2011 Mar;45(1):1. PMID: 21572816Free PMC Article
Malfertheiner P, Chan FK, McColl KE
Lancet 2009 Oct 24;374(9699):1449-61. Epub 2009 Aug 13 doi: 10.1016/S0140-6736(09)60938-7. PMID: 19683340
Medarov BI
Mayo Clin Proc 2009 Mar;84(3):261-7. doi: 10.4065/84.3.261. PMID: 19252114Free PMC Article
Ali W, Sikora SS, Banerjee D, Kapoor VK, Saraswat VA, Saxena R, Kaushik SP
Aust N Z J Surg 1993 Jun;63(6):466-7. doi: 10.1111/j.1445-2197.1993.tb00429.x. PMID: 8498916

Clinical prediction guides

Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L
Am J Med 2022 Oct;135(10):1231-1243.e8. Epub 2022 Jun 7 doi: 10.1016/j.amjmed.2022.05.031. PMID: 35679879Free PMC Article
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
Costable NJ, Greenwald DA
Clin Geriatr Med 2021 Feb;37(1):155-172. doi: 10.1016/j.cger.2020.09.001. PMID: 33213769
Falkeis-Veits C, Vieth M
Adv Exp Med Biol 2019;1149:121-134. doi: 10.1007/5584_2019_362. PMID: 31016630
Rahman SI, Saeian K
Crit Care Clin 2016 Apr;32(2):223-39. Epub 2016 Feb 12 doi: 10.1016/j.ccc.2015.12.002. PMID: 27016164

Recent systematic reviews

Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L
Am J Med 2022 Oct;135(10):1231-1243.e8. Epub 2022 Jun 7 doi: 10.1016/j.amjmed.2022.05.031. PMID: 35679879Free PMC Article
Gisbert JP, Alcedo J, Amador J, Bujanda L, Calvet X, Castro-Fernández M, Fernández-Salazar L, Gené E, Lanas Á, Lucendo AJ, Molina-Infante J, Nyssen OP, Pérez-Aisa A, Puig I
Gastroenterol Hepatol 2022 May;45(5):392-417. Epub 2021 Oct 7 doi: 10.1016/j.gastrohep.2021.07.011. PMID: 34629204
Kamada T, Satoh K, Itoh T, Ito M, Iwamoto J, Okimoto T, Kanno T, Sugimoto M, Chiba T, Nomura S, Mieda M, Hiraishi H, Yoshino J, Takagi A, Watanabe S, Koike K
J Gastroenterol 2021 Apr;56(4):303-322. Epub 2021 Feb 23 doi: 10.1007/s00535-021-01769-0. PMID: 33620586Free PMC Article
Du LJ, Chen BR, Kim JJ, Kim S, Shen JH, Dai N
World J Gastroenterol 2016 Mar 28;22(12):3486-95. doi: 10.3748/wjg.v22.i12.3486. PMID: 27022230Free PMC Article
Malik AA; Shams-ul-Bari, Wani KA, Khaja AR
Saudi J Gastroenterol 2010 Jan-Mar;16(1):3-7. doi: 10.4103/1319-3767.58760. PMID: 20065566Free PMC Article

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