U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ulcer disease

MedGen UID:
22541
•Concept ID:
C0041582
•
Pathologic Function
Synonyms: Ulcer; Ulcers
SNOMED CT: Ulcer - lesion (56208002); Ulcer (429040005); Ulcerative (255321001); Ulcer (56208002); Ulceration (56208002); Ulcerative lesion (56208002); Ulcus (56208002)
 
Monarch Initiative: MONDO:0043839

Definition

A circumscribed inflammatory and often suppurating lesion on the skin or an internal mucous surface resulting in necrosis of tissue. [from NCI]

Professional guidelines

PubMed

Evidence-based clinical practice guidelines for peptic ulcer disease 2020.
Kamada T, Satoh K, Itoh T, Ito M, Iwamoto J, Okimoto T, Kanno T, Sugimoto M, Chiba T, Nomura S, Mieda M, Hiraishi H, Yoshino J, Takagi A, Watanabe S, Koike K
J Gastroenterol 2021 Apr;56(4):303-322. Epub 2021 Feb 23 doi: 10.1007/s00535-021-01769-0. PMID: 33620586Free PMC Article
Diagnosis and Treatment of Peptic Ulcer Disease.
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Recent clinical studies

Etiology

Peptic ulcer.
Laucirica I, García Iglesias P, Calvet X
Med Clin (Barc) 2023 Sep 29;161(6):260-266. Epub 2023 Jun 24 doi: 10.1016/j.medcli.2023.05.008. PMID: 37365037
Non-steroidal anti-inflammatory drugs and the gastrointestinal tract.
Tai FWD, McAlindon ME
Clin Med (Lond) 2021 Mar;21(2):131-134. doi: 10.7861/clinmed.2021-0039. PMID: 33762373Free PMC Article
Diagnosis and Treatment of Peptic Ulcer Disease.
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
Peptic Ulcer Disease and Helicobacter pylori infection.
Narayanan M, Reddy KM, Marsicano E
Mo Med 2018 May-Jun;115(3):219-224. PMID: 30228726Free PMC Article
Lifestyle and Peptic Ulcer Disease.
Yegen BC
Curr Pharm Des 2018;24(18):2034-2040. doi: 10.2174/1381612824666180510092303. PMID: 29745325

Diagnosis

Peptic Ulcer Disease.
Tuerk E, Doss S, Polsley K
Prim Care 2023 Sep;50(3):351-362. Epub 2023 May 24 doi: 10.1016/j.pop.2023.03.003. PMID: 37516507
Peptic ulcer.
Laucirica I, García Iglesias P, Calvet X
Med Clin (Barc) 2023 Sep 29;161(6):260-266. Epub 2023 Jun 24 doi: 10.1016/j.medcli.2023.05.008. PMID: 37365037
Diagnosis and Treatment of Peptic Ulcer Disease.
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
Acid Peptic Disease.
Kempenich JW, Sirinek KR
Surg Clin North Am 2018 Oct;98(5):933-944. doi: 10.1016/j.suc.2018.06.003. PMID: 30243454
Peptic Ulcer Disease and Helicobacter pylori infection.
Narayanan M, Reddy KM, Marsicano E
Mo Med 2018 May-Jun;115(3):219-224. PMID: 30228726Free PMC Article

Therapy

Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials.
Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H, Holland L, Wilson K, Bhala N, Hawkey C, Hochberg M, Hunt R, Laine L, Lanas A, Patrono C, Baigent C
Lancet Gastroenterol Hepatol 2018 Apr;3(4):231-241. Epub 2018 Feb 21 doi: 10.1016/S2468-1253(18)30037-2. PMID: 29475806Free PMC Article
Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people.
Ford AC, Gurusamy KS, Delaney B, Forman D, Moayyedi P
Cochrane Database Syst Rev 2016 Apr 19;4(4):CD003840. doi: 10.1002/14651858.CD003840.pub5. PMID: 27092708Free PMC Article
Peptic-ulcer disease.
Chan FK, Leung WK
Lancet 2002 Sep 21;360(9337):933-41. doi: 10.1016/s0140-6736(02)11030-0. PMID: 12354485
Methysergide.
Silberstein SD
Cephalalgia 1998 Sep;18(7):421-35. doi: 10.1046/j.1468-2982.1998.1807421.x. PMID: 9793694
Ranitidine.
Strum WB
JAMA 1983 Oct 14;250(14):1894-6. PMID: 6312110

Prognosis

Surgical management of peptic ulcer disease.
Wang A, Yerxa J, Agarwal S, Turner MC, Schroder V, Youngwirth LM, Lagoo-Deenadayalan S, Pappas TN
Curr Probl Surg 2020 Feb;57(2):100728. Epub 2020 Jan 7 doi: 10.1016/j.cpsurg.2019.100728. PMID: 32138833
Buruli ulcer disease.
Ofori-Adjei D
Ghana Med J 2011 Mar;45(1):1. PMID: 21572816Free PMC Article
Peptic ulcer disease.
Malfertheiner P, Chan FK, McColl KE
Lancet 2009 Oct 24;374(9699):1449-61. Epub 2009 Aug 13 doi: 10.1016/S0140-6736(09)60938-7. PMID: 19683340
Milk-alkali syndrome.
Medarov BI
Mayo Clin Proc 2009 Mar;84(3):261-7. doi: 10.4065/84.3.261. PMID: 19252114Free PMC Article
Gastroduodenal tuberculosis.
Ali W, Sikora SS, Banerjee D, Kapoor VK, Saraswat VA, Saxena R, Kaushik SP
Aust N Z J Surg 1993 Jun;63(6):466-7. doi: 10.1111/j.1445-2197.1993.tb00429.x. PMID: 8498916

Clinical prediction guides

Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis.
Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L
Am J Med 2022 Oct;135(10):1231-1243.e8. Epub 2022 Jun 7 doi: 10.1016/j.amjmed.2022.05.031. PMID: 35679879Free PMC Article
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
Upper Gastrointestinal Bleeding.
Costable NJ, Greenwald DA
Clin Geriatr Med 2021 Feb;37(1):155-172. doi: 10.1016/j.cger.2020.09.001. PMID: 33213769
Non-malignant Helicobacter pylori-Associated Diseases.
Falkeis-Veits C, Vieth M
Adv Exp Med Biol 2019;1149:121-134. doi: 10.1007/5584_2019_362. PMID: 31016630
Nonvariceal Upper Gastrointestinal Bleeding.
Rahman SI, Saeian K
Crit Care Clin 2016 Apr;32(2):223-39. Epub 2016 Feb 12 doi: 10.1016/j.ccc.2015.12.002. PMID: 27016164

Recent systematic reviews

Association of Antisecretory Drugs with Upper Gastrointestinal Bleeding in Patients Using Oral Anticoagulants: A Systematic Review and Meta-Analysis.
Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L
Am J Med 2022 Oct;135(10):1231-1243.e8. Epub 2022 Jun 7 doi: 10.1016/j.amjmed.2022.05.031. PMID: 35679879Free PMC Article
V Spanish Consensus Conference on Helicobacter pylori infection treatment.
Gisbert JP, Alcedo J, Amador J, Bujanda L, Calvet X, Castro-Fernández M, Fernández-Salazar L, Gené E, Lanas Á, Lucendo AJ, Molina-Infante J, Nyssen OP, Pérez-Aisa A, Puig I
Gastroenterol Hepatol 2022 May;45(5):392-417. Epub 2021 Oct 7 doi: 10.1016/j.gastrohep.2021.07.011. PMID: 34629204
Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis.
Du LJ, Chen BR, Kim JJ, Kim S, Shen JH, Dai N
World J Gastroenterol 2016 Mar 28;22(12):3486-95. doi: 10.3748/wjg.v22.i12.3486. PMID: 27022230Free PMC Article
Ecology and transmission of Buruli ulcer disease: a systematic review.
Merritt RW, Walker ED, Small PL, Wallace JR, Johnson PD, Benbow ME, Boakye DA
PLoS Negl Trop Dis 2010 Dec 14;4(12):e911. doi: 10.1371/journal.pntd.0000911. PMID: 21179505Free PMC Article
Meckel's diverticulum-Revisited.
Malik AA; Shams-ul-Bari, Wani KA, Khaja AR
Saudi J Gastroenterol 2010 Jan-Mar;16(1):3-7. doi: 10.4103/1319-3767.58760. PMID: 20065566Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...