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AJCC grade 1 sarcoma

MedGen UID:
231330
•Concept ID:
C1332066
•
Neoplastic Process
Synonyms: AJCC G1 Sarcoma; aJCC G1 sarcoma; AJCC Grade 1 Sarcoma; aJCC grade 1 sarcoma; AJCC Grade I Sarcoma; aJCC grade I sarcoma; Well Differentiated Sarcoma; well differentiated sarcoma
 
Monarch Initiative: MONDO:0005104

Definition

Cancer cells are given a score of 1 to 3, with 1 being assigned when they look similar to normal cells and 3 being used when the cancer cells look very abnormal. Certain types of sarcoma are given a higher score automatically. See also NCIt:C9419 (Synonym of AJCC G1 Sarcoma) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAJCC grade 1 sarcoma

Professional guidelines

PubMed

Management and outcomes among patients with sarcomatoid hepatocellular carcinoma: A population-based analysis.
Wu L, Tsilimigras DI, Farooq A, Hyer JM, Merath K, Paredes AZ, Mehta R, Sahara K, Shen F, Pawlik TM
Cancer 2019 Nov 1;125(21):3767-3775. Epub 2019 Jul 12 doi: 10.1002/cncr.32396. PMID: 31299092

Recent clinical studies

Etiology

Establishment of a staging system for visceral sarcoma.
Wang B, Xu L, Fang M, Zheng B, Yan W
Cancer Med 2024 Jan;13(1):e6791. Epub 2023 Dec 16 doi: 10.1002/cam4.6791. PMID: 38102873Free PMC Article
Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.
Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
A Proposed Staging System for Improved Prognostication of MDM2-amplified Liposarcoma.
Tucci JJ, Dashti NK, Cates JMM
Am J Surg Pathol 2021 Jan;45(1):101-107. doi: 10.1097/PAS.0000000000001554. PMID: 32796171
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521

Diagnosis

Establishment of a staging system for visceral sarcoma.
Wang B, Xu L, Fang M, Zheng B, Yan W
Cancer Med 2024 Jan;13(1):e6791. Epub 2023 Dec 16 doi: 10.1002/cam4.6791. PMID: 38102873Free PMC Article
Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.
Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Nathenson MJ, Barysauskas CM, Nathenson RA, Regine WF, Hanna N, Sausville E
World J Surg Oncol 2018 Oct 11;16(1):203. doi: 10.1186/s12957-018-1505-4. PMID: 30309356Free PMC Article

Therapy

Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
A novel nomogram for predicting cancer-specific survival in women with uterine sarcoma: a large population-based study.
Li YJ, Lyu J, Li C, He HR, Wang JF, Wang YL, Fang J, Ji J
BMC Womens Health 2022 May 14;22(1):175. doi: 10.1186/s12905-022-01739-5. PMID: 35568940Free PMC Article
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Chemotherapy influences the pseudocapsule composition in soft tissue sarcomas.
O'Donnell PW, Manivel JC, Cheng EY, Clohisy DR
Clin Orthop Relat Res 2014 Mar;472(3):849-55. doi: 10.1007/s11999-013-3022-7. PMID: 23640206Free PMC Article

Prognosis

Establishment of a staging system for visceral sarcoma.
Wang B, Xu L, Fang M, Zheng B, Yan W
Cancer Med 2024 Jan;13(1):e6791. Epub 2023 Dec 16 doi: 10.1002/cam4.6791. PMID: 38102873Free PMC Article
Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
H3K27me3 and VEGF is associated with poor prognosis in patients with synovial sarcoma.
Diao Y, Zhang P, Dai R, Xu J, Feng H
Pathol Res Pract 2018 Jul;214(7):974-977. Epub 2018 May 20 doi: 10.1016/j.prp.2018.05.015. PMID: 29803658
Distant metastasis in patients with myxofibrosarcoma.
Tsuchie H, Kaya M, Nagasawa H, Emori M, Murahashi Y, Mizushima E, Miyakoshi N, Yamashita T, Shimada Y
Ups J Med Sci 2017 Aug;122(3):190-193. Epub 2017 Aug 17 doi: 10.1080/03009734.2017.1356404. PMID: 28814152Free PMC Article

Clinical prediction guides

Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Multivariate evaluation of prognostic markers in synovial sarcoma.
Larque AB, Lozano-Calderon S, Cote GM, Chen YL, Hung YP, Deshpande V, Nielsen GP, Chebib I
J Clin Pathol 2023 Dec 14;77(1):16-21. doi: 10.1136/jcp-2022-208518. PMID: 36288948
Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
A Proposed Staging System for Improved Prognostication of MDM2-amplified Liposarcoma.
Tucci JJ, Dashti NK, Cates JMM
Am J Surg Pathol 2021 Jan;45(1):101-107. doi: 10.1097/PAS.0000000000001554. PMID: 32796171
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521

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