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Low Grade Sarcoma

MedGen UID:
272799
•Concept ID:
C1334419
•
Neoplastic Process
Synonyms: Low-Grade Sarcoma; Well or Moderately Differentiated Sarcoma

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Sarcoma

Professional guidelines

PubMed

Differential diagnosis of myxoid soft tissue tumors. Experience in the Clinical University Hospital of Valencia.
Alfaro-Cervelló C, Nieto G, Navarro S
Rev Esp Patol 2022 Jul-Sep;55(3):185-191. Epub 2019 Nov 4 doi: 10.1016/j.patol.2019.07.005. PMID: 35779885
Recurrent retroperitoneal sarcomas: Clinical outcomes of surgical treatment and prognostic factors.
Tropea S, Mocellin S, Damiani GB, Stramare R, Aliberti C, Del Fiore P, Rossi CR, Rastrelli M
Eur J Surg Oncol 2021 May;47(5):1201-1206. Epub 2020 Sep 9 doi: 10.1016/j.ejso.2020.08.030. PMID: 32950313
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2.
Chokoeva AA, Tchernev G, Cardoso JC, Patterson JW, Dechev I, Valkanov S, Zanardelli M, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2015 Jun;28(2):178-86. Epub 2015 Mar 26 doi: 10.1177/0394632015575977. PMID: 25816393

Recent clinical studies

Etiology

18 F-FDG PET/CT in Extensive Follicular Dendritic Cell Sarcoma With Response Assessment to Chemotherapy.
Prakash KDJ, Sharma S, Nazar AH, Ora M, Gambhir S
Clin Nucl Med 2023 Jul 1;48(7):e347-e349. Epub 2023 May 11 doi: 10.1097/RLU.0000000000004697. PMID: 37167157
Expanding the Spectrum of the Soft Tissue Tumors with Kinase Gene Fusions: A Pediatric Spindle Cell Neoplasm Harboring MTAP-RAF1 Fusion.
Dogukan FM, Erdem ZB, Danyeli AE
Fetal Pediatr Pathol 2023 Jun;42(3):512-517. Epub 2022 Dec 9 doi: 10.1080/15513815.2022.2154135. PMID: 36484718
Retrospective analysis of 11 cases of primary cardiac valve tumors.
Li T, Liu C, Luo Y, Gong S, Xiao Y, Wang X, Wang Y
Anatol J Cardiol 2019 Jan;21(1):11-17. doi: 10.14744/AnatolJCardiol.2018.40325. PMID: 30587716Free PMC Article
Acral myxoinflammatory fibroblastic sarcomas: MRI findings in four cases.
Narváez JA, Martinez S, Dodd LG, Brigman BE
AJR Am J Roentgenol 2007 May;188(5):1302-5. doi: 10.2214/AJR.05.0141. PMID: 17449774
Microscopic margins and results of surgery for dermatofibrosarcoma protuberans.
Popov P, Böhling T, Asko-Seljavaara S, Tukiainen E
Plast Reconstr Surg 2007 May;119(6):1779-1784. doi: 10.1097/01.prs.0000246491.79337.25. PMID: 17440355

Diagnosis

Biphenotypic Sinonasal Sarcoma with PAX7 Expression.
Georgantzoglou N, Green D, Stephen SA, Kerr DA, Linos K
Int J Surg Pathol 2022 Sep;30(6):642-645. Epub 2022 Feb 11 doi: 10.1177/10668969221080082. PMID: 35147045
Primary Orbital Chondromyxoid Fibroma: A Rare Case.
Mullen MG, Somogyi M, Maxwell SP, Prabhu V, Yoo DK
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S114-S116. doi: 10.1097/IOP.0000000000000857. PMID: 28099230
A Pediatric Case of Metastatic Conventional Parosteal Osteosarcoma Treated With Multidrug Chemotherapy.
Nodomi S, Umeda K, Okamoto T, Saida S, Hiramatsu H, Watanabe K, Adachi S, Heike T
Pediatr Blood Cancer 2016 Aug;63(8):1471-3. Epub 2016 May 3 doi: 10.1002/pbc.26052. PMID: 27149276
Primary asymptomatic desmoid tumor of the mesentery.
Efthimiopoulos GA, Chatzifotiou D, Drogouti M, Zafiriou G
Am J Case Rep 2015 Mar 17;16:160-3. doi: 10.12659/AJCR.892521. PMID: 25782060Free PMC Article
Oral ectomesenchymal chondromyxoid tumor: case report and literature review.
Portnof JE, Friedman JM, Reich R, Freedman PD, Behrman DA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Oct;108(4):e20-4. Epub 2009 Aug 28 doi: 10.1016/j.tripleo.2009.05.040. PMID: 19716722

Therapy

Successful Crizotinib-targeted Therapy of Pediatric Unresectable ERC1::ALK Fusion Sarcoma.
Wood ML, Fanburg-Smith JC, Brian JM, White JC, Powell JL, Freiberg AS
J Pediatr Hematol Oncol 2024 Mar 1;46(2):e184-e187. Epub 2023 Dec 15 doi: 10.1097/MPH.0000000000002777. PMID: 38099690Free PMC Article
A Pediatric Case of Metastatic Conventional Parosteal Osteosarcoma Treated With Multidrug Chemotherapy.
Nodomi S, Umeda K, Okamoto T, Saida S, Hiramatsu H, Watanabe K, Adachi S, Heike T
Pediatr Blood Cancer 2016 Aug;63(8):1471-3. Epub 2016 May 3 doi: 10.1002/pbc.26052. PMID: 27149276
Mohs micrographic surgery for dermatofibrosarcoma protuberans (DFSP): a single-centre series of 76 patients treated by frozen-section Mohs micrographic surgery with a review of the literature.
Loghdey MS, Varma S, Rajpara SM, Al-Rawi H, Perks G, Perkins W
J Plast Reconstr Aesthet Surg 2014 Oct;67(10):1315-21. Epub 2014 May 23 doi: 10.1016/j.bjps.2014.05.021. PMID: 25012249
Imatinib as effective therapy for dermatofibrosarcoma protuberans: proof of concept of the autocrine hypothesis for cancer.
Handolias D, McArthur GA
Future Oncol 2008 Apr;4(2):211-7. doi: 10.2217/14796694.4.2.211. PMID: 18407734
Microscopic margins and results of surgery for dermatofibrosarcoma protuberans.
Popov P, Böhling T, Asko-Seljavaara S, Tukiainen E
Plast Reconstr Surg 2007 May;119(6):1779-1784. doi: 10.1097/01.prs.0000246491.79337.25. PMID: 17440355

Prognosis

Myxoid chondrosarcoma extraskeletal in pelvis location : a case report.
Chahdi H, Chafry B, Allaoui M
Tunis Med 2018 Jan;96(1):84-86. PMID: 30325000
Clear-Cell Atypical Fibroxanthoma: A Combined Immunohistochemistry Analysis.
Brau Javier CN, Valentín Colón DC, Sánchez JL, Sánchez JE
Am J Dermatopathol 2016 Oct;38(10):775-9. doi: 10.1097/DAD.0000000000000529. PMID: 26959699
Microscopic margins and results of surgery for dermatofibrosarcoma protuberans.
Popov P, Böhling T, Asko-Seljavaara S, Tukiainen E
Plast Reconstr Surg 2007 May;119(6):1779-1784. doi: 10.1097/01.prs.0000246491.79337.25. PMID: 17440355
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma.
Amant F, Steenkiste E, Schurmans K, Verbist L, Abeler VM, Tulunay G, de Jonge E, Massuger L, Moerman P, Vergote I
Int J Gynecol Cancer 2004 Nov-Dec;14(6):1118-21. doi: 10.1111/j.1048-891X.2004.14610.x. PMID: 15571618
Dermatofibrosarcoma protuberans of the vulva.
Leake JF, Buscema J, Cho KR, Currie JL
Gynecol Oncol 1991 Jun;41(3):245-9. doi: 10.1016/0090-8258(91)90317-x. PMID: 1869103

Clinical prediction guides

A novel MAP3K7CL-ERG fusion in a molecularly confirmed case of dermatofibrosarcoma protuberans with fibrosarcomatous transformation.
Maloney N, Bridge JA, de Abreu F, Korkolopoulou P, Sakellariou S, Linos K
J Cutan Pathol 2019 Jul;46(7):532-537. Epub 2019 May 3 doi: 10.1111/cup.13469. PMID: 30950098
Prognostic factors for uterine adenosarcoma: a review.
Nathenson MJ, Conley AP
Expert Rev Anticancer Ther 2018 Nov;18(11):1093-1100. Epub 2018 Sep 11 doi: 10.1080/14737140.2018.1518136. PMID: 30169984
Clear-Cell Atypical Fibroxanthoma: A Combined Immunohistochemistry Analysis.
Brau Javier CN, Valentín Colón DC, Sánchez JL, Sánchez JE
Am J Dermatopathol 2016 Oct;38(10):775-9. doi: 10.1097/DAD.0000000000000529. PMID: 26959699
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma.
Amant F, Steenkiste E, Schurmans K, Verbist L, Abeler VM, Tulunay G, de Jonge E, Massuger L, Moerman P, Vergote I
Int J Gynecol Cancer 2004 Nov-Dec;14(6):1118-21. doi: 10.1111/j.1048-891X.2004.14610.x. PMID: 15571618
Müllerian adenosarcomalike tumor of the seminal vesicle. A case report with immunohistochemical and ultrastructural observations.
Laurila P, Leivo I, Mäkisalo H, Ruutu M, Miettinen M
Arch Pathol Lab Med 1992 Oct;116(10):1072-6. PMID: 1329693

Recent systematic reviews

Radiotherapy versus limb-sparing surgery alone in low-grade soft-tissue sarcoma of the extremity and trunk wall: a systematic review and meta-analysis.
Trieu D, Gong H, Benoit D, Choong PFM
ANZ J Surg 2024 Apr;94(4):566-571. Epub 2024 Jan 15 doi: 10.1111/ans.18858. PMID: 38225730
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article

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