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Low Grade Sarcoma

MedGen UID:
272799
•Concept ID:
C1334419
•
Neoplastic Process
Synonyms: Low-Grade Sarcoma; Well or Moderately Differentiated Sarcoma

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Sarcoma

Professional guidelines

PubMed

Differential diagnosis of myxoid soft tissue tumors. Experience in the Clinical University Hospital of Valencia.
Alfaro-Cervelló C, Nieto G, Navarro S
Rev Esp Patol 2022 Jul-Sep;55(3):185-191. Epub 2019 Nov 4 doi: 10.1016/j.patol.2019.07.005. PMID: 35779885
Recurrent retroperitoneal sarcomas: Clinical outcomes of surgical treatment and prognostic factors.
Tropea S, Mocellin S, Damiani GB, Stramare R, Aliberti C, Del Fiore P, Rossi CR, Rastrelli M
Eur J Surg Oncol 2021 May;47(5):1201-1206. Epub 2020 Sep 9 doi: 10.1016/j.ejso.2020.08.030. PMID: 32950313
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2.
Chokoeva AA, Tchernev G, Cardoso JC, Patterson JW, Dechev I, Valkanov S, Zanardelli M, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2015 Jun;28(2):178-86. Epub 2015 Mar 26 doi: 10.1177/0394632015575977. PMID: 25816393

Recent clinical studies

Etiology

Different sonographic presentations of dermatofibrosarcoma protuberans.
Whittle C, Andrews A, Coulon G, Castro A
J Ultrasound 2024 Mar;27(1):61-65. Epub 2023 Jul 14 doi: 10.1007/s40477-023-00796-2. PMID: 37450197Free PMC Article
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article
Locally aggressive rarely metastazing tumors and low-grade sarcoma in children, adolescents and young adults: The benefits of a national network.
Brisset C, Carton M, Chemin-Airiau C, Karanian M, Vérité C, Corradini N, Mascard E, Gouin F, Bonvalot S, Minard-Colin V, Fayard C, Pannier S, Blay JY, Le Nail LR, Le Loarer F, Brisse HJ, Chotel F, Pierron G, Tirode F, Defachelles AS, Toulmonde M, Orbach D
Eur J Surg Oncol 2022 Mar;48(3):508-517. Epub 2021 Sep 14 doi: 10.1016/j.ejso.2021.09.006. PMID: 34561126
Role of Radiation Therapy for Newly Diagnosed Retroperitoneal Sarcoma.
Lam MB, Baldini EH, Reijers SJM, Haas RL, DeLaney TF
Curr Treat Options Oncol 2021 Jul 2;22(9):75. doi: 10.1007/s11864-021-00877-6. PMID: 34213610
Prognostic factors for uterine adenosarcoma: a review.
Nathenson MJ, Conley AP
Expert Rev Anticancer Ther 2018 Nov;18(11):1093-1100. Epub 2018 Sep 11 doi: 10.1080/14737140.2018.1518136. PMID: 30169984

Diagnosis

Superficial CD34 Positive Fibroblastic Tumour with Myxoid Stroma.
Bruce-Brand C, Conradie W, Schneider JW
Int J Surg Pathol 2023 Aug;31(5):751-754. Epub 2022 Oct 11 doi: 10.1177/10668969221126109. PMID: 36221951Free PMC Article
Low-grade endometrial stromal sarcoma-like tumors in male with JAZF1 gene fusions.
Dermawan JK, Zhang L, Singer S, Chi P, Antonescu CR
Genes Chromosomes Cancer 2022 Feb;61(2):63-70. Epub 2021 Oct 23 doi: 10.1002/gcc.23003. PMID: 34651371Free PMC Article
Cytopathology of myxoinflammatory fibroblastic sarcoma: a series of eight cases and review of the literature.
Wangsiricharoen S, Ali SZ, Wakely PE Jr
J Am Soc Cytopathol 2021 May-Jun;10(3):310-320. Epub 2021 Jan 9 doi: 10.1016/j.jasc.2020.12.004. PMID: 33431307
Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies.
Thway K, Noujaim J, Jones RL, Fisher C
Ann Diagn Pathol 2016 Dec;25:64-71. Epub 2016 Sep 27 doi: 10.1016/j.anndiagpath.2016.09.013. PMID: 27806849
Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature.
Cowan ML, Thompson LD, Leon ME, Bishop JA
Head Neck Pathol 2016 Jun;10(2):161-6. Epub 2015 Aug 15 doi: 10.1007/s12105-015-0647-8. PMID: 26276044Free PMC Article

Therapy

Radiotherapy versus limb-sparing surgery alone in low-grade soft-tissue sarcoma of the extremity and trunk wall: a systematic review and meta-analysis.
Trieu D, Gong H, Benoit D, Choong PFM
ANZ J Surg 2024 Apr;94(4):566-571. Epub 2024 Jan 15 doi: 10.1111/ans.18858. PMID: 38225730
Role of Radiation Therapy for Newly Diagnosed Retroperitoneal Sarcoma.
Lam MB, Baldini EH, Reijers SJM, Haas RL, DeLaney TF
Curr Treat Options Oncol 2021 Jul 2;22(9):75. doi: 10.1007/s11864-021-00877-6. PMID: 34213610
Metastatic Low-Grade Sarcoma with CARS-ALK Fusion Dramatically Responded to Multiple ALK Tyrosine Kinase Inhibitors: A Case Report with Comprehensive Genomic Analysis.
Jiao XD, Liu K, Xu M, Yu G, Liu D, Huang T, Qin BD, Liu M, Wu Y, Ling Y, Liu J, He X, Wang L, Li Y, Chen S, Zang YS
Oncologist 2021 Apr;26(4):e524-e529. Epub 2020 Oct 16 doi: 10.1002/onco.13543. PMID: 32997436Free PMC Article
A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in high-grade uterine sarcoma after stabilization or response to doxorubicin ± ifosfamide following surgery or in metastatic first line treatment (EORTC62113).
Ray-Coquard I, Hatcher H, Bompas E, Casado A, Westermann A, Isambert N, Casali PG, Pratap S, Stark D, Valverde C, Anand A, Huizing M, Floquet A, Lindner L, Hermes B, Seddon B, Coens C, Jones R, Reed N
Int J Gynecol Cancer 2020 Oct;30(10):1633-1637. Epub 2020 Jun 15 doi: 10.1136/ijgc-2020-001519. PMID: 32546554
Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma.
Ortiz MV, Magnan H, Slotkin EK, Ambati SR, Chou AJ, Wexler LH, Meyers PA, Walsh MF, Heaton T, Girardi LN, Wolden SL, Price AP, Kennedy JA, Zehir A, Hameed M, Berger MF, Kentsis A, Shukla N
J Pediatr Hematol Oncol 2017 Nov;39(8):e443-e445. doi: 10.1097/MPH.0000000000000754. PMID: 28060130Free PMC Article

Prognosis

Locally aggressive rarely metastazing tumors and low-grade sarcoma in children, adolescents and young adults: The benefits of a national network.
Brisset C, Carton M, Chemin-Airiau C, Karanian M, Vérité C, Corradini N, Mascard E, Gouin F, Bonvalot S, Minard-Colin V, Fayard C, Pannier S, Blay JY, Le Nail LR, Le Loarer F, Brisse HJ, Chotel F, Pierron G, Tirode F, Defachelles AS, Toulmonde M, Orbach D
Eur J Surg Oncol 2022 Mar;48(3):508-517. Epub 2021 Sep 14 doi: 10.1016/j.ejso.2021.09.006. PMID: 34561126
Role of Radiation Therapy for Newly Diagnosed Retroperitoneal Sarcoma.
Lam MB, Baldini EH, Reijers SJM, Haas RL, DeLaney TF
Curr Treat Options Oncol 2021 Jul 2;22(9):75. doi: 10.1007/s11864-021-00877-6. PMID: 34213610
Tumor grade in soft-tissue sarcoma: Prediction with magnetic resonance imaging texture analysis.
Hong JH, Jee WH, Jung CK, Chung YG
Medicine (Baltimore) 2020 Jul 2;99(27):e20880. doi: 10.1097/MD.0000000000020880. PMID: 32629676Free PMC Article
Prognostic factors for uterine adenosarcoma: a review.
Nathenson MJ, Conley AP
Expert Rev Anticancer Ther 2018 Nov;18(11):1093-1100. Epub 2018 Sep 11 doi: 10.1080/14737140.2018.1518136. PMID: 30169984
Uterine leiomyosarcoma.
Hannigan EV, Gomez LG
Am J Obstet Gynecol 1979 Jul 1;134(5):557-64. doi: 10.1016/0002-9378(79)90841-x. PMID: 453295

Clinical prediction guides

Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article
Locally aggressive rarely metastazing tumors and low-grade sarcoma in children, adolescents and young adults: The benefits of a national network.
Brisset C, Carton M, Chemin-Airiau C, Karanian M, Vérité C, Corradini N, Mascard E, Gouin F, Bonvalot S, Minard-Colin V, Fayard C, Pannier S, Blay JY, Le Nail LR, Le Loarer F, Brisse HJ, Chotel F, Pierron G, Tirode F, Defachelles AS, Toulmonde M, Orbach D
Eur J Surg Oncol 2022 Mar;48(3):508-517. Epub 2021 Sep 14 doi: 10.1016/j.ejso.2021.09.006. PMID: 34561126
Recurrent retroperitoneal sarcomas: Clinical outcomes of surgical treatment and prognostic factors.
Tropea S, Mocellin S, Damiani GB, Stramare R, Aliberti C, Del Fiore P, Rossi CR, Rastrelli M
Eur J Surg Oncol 2021 May;47(5):1201-1206. Epub 2020 Sep 9 doi: 10.1016/j.ejso.2020.08.030. PMID: 32950313
Tumor grade in soft-tissue sarcoma: Prediction with magnetic resonance imaging texture analysis.
Hong JH, Jee WH, Jung CK, Chung YG
Medicine (Baltimore) 2020 Jul 2;99(27):e20880. doi: 10.1097/MD.0000000000020880. PMID: 32629676Free PMC Article
Prognostic factors for uterine adenosarcoma: a review.
Nathenson MJ, Conley AP
Expert Rev Anticancer Ther 2018 Nov;18(11):1093-1100. Epub 2018 Sep 11 doi: 10.1080/14737140.2018.1518136. PMID: 30169984

Recent systematic reviews

Radiotherapy versus limb-sparing surgery alone in low-grade soft-tissue sarcoma of the extremity and trunk wall: a systematic review and meta-analysis.
Trieu D, Gong H, Benoit D, Choong PFM
ANZ J Surg 2024 Apr;94(4):566-571. Epub 2024 Jan 15 doi: 10.1111/ans.18858. PMID: 38225730
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review.
Turri-Zanoni M, Dalfino G, Lechner M, Dallan I, Battaglia P, Facco C, Franzi F, Gravante G, Ferrari M, Terzakis D, Jay A, Forster MD, Ambrosoli AL, Bignami M, Georgalas C, Herman P, Nicolai P, Lund VJ, Castelnuovo P
Acta Otorhinolaryngol Ital 2022 Dec;42(6):545-553. doi: 10.14639/0392-100X-N2087. PMID: 36654521Free PMC Article

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