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Sarcoma by AJCC Grade

MedGen UID:
233435
•Concept ID:
C1335919
•
Neoplastic Process
Synonym: AJCC Tumor Grade in Sarcoma

Professional guidelines

PubMed

Risk Assessment of Visceral Sarcomas: A Comparative Study of 2698 Cases from the SEER Database.
Dashti NK, Cates JMM
Ann Surg Oncol 2021 Oct;28(11):6852-6860. Epub 2021 Feb 4 doi: 10.1245/s10434-020-09576-2. PMID: 33538930
Management and outcomes among patients with sarcomatoid hepatocellular carcinoma: A population-based analysis.
Wu L, Tsilimigras DI, Farooq A, Hyer JM, Merath K, Paredes AZ, Mehta R, Sahara K, Shen F, Pawlik TM
Cancer 2019 Nov 1;125(21):3767-3775. Epub 2019 Jul 12 doi: 10.1002/cncr.32396. PMID: 31299092

Recent clinical studies

Etiology

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
Comparison of the AJCC, MSTS, and Modified Spanier Systems for Clinical and Pathologic Staging of Osteosarcoma.
Cates JM
Am J Surg Pathol 2017 Mar;41(3):405-413. doi: 10.1097/PAS.0000000000000774. PMID: 28195881
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Diagnosis

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.
Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Comparison of the AJCC, MSTS, and Modified Spanier Systems for Clinical and Pathologic Staging of Osteosarcoma.
Cates JM
Am J Surg Pathol 2017 Mar;41(3):405-413. doi: 10.1097/PAS.0000000000000774. PMID: 28195881
Staging soft tissue sarcoma: evolution and change.
Kotilingam D, Lev DC, Lazar AJ, Pollock RE
CA Cancer J Clin 2006 Sep-Oct;56(5):282-91; quiz 314-5. doi: 10.3322/canjclin.56.5.282. PMID: 17005597
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Therapy

Development and validation of a nomogram for predicting prognosis of high-grade chondrosarcoma: A surveillance, epidemiology, and end results-based population analysis.
Sun Y, Ouyang C, Zhang Y, Li Y, Liu Y, Jiang M, Nong L, Gao G
J Orthop Surg (Hong Kong) 2023 May-Aug;31(2):10225536231174255. doi: 10.1177/10225536231174255. PMID: 37147017
Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
A novel nomogram for predicting cancer-specific survival in women with uterine sarcoma: a large population-based study.
Li YJ, Lyu J, Li C, He HR, Wang JF, Wang YL, Fang J, Ji J
BMC Womens Health 2022 May 14;22(1):175. doi: 10.1186/s12905-022-01739-5. PMID: 35568940Free PMC Article
Identifying the Prognosis Factors and Predicting the Survival Probability in Patients with Non-Metastatic Chondrosarcoma from the SEER Database.
Huang R, Sun Z, Zheng H, Yan P, Hu P, Yin H, Zhang J, Meng T, Huang Z
Orthop Surg 2019 Oct;11(5):801-810. doi: 10.1111/os.12521. PMID: 31663279Free PMC Article

Prognosis

Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
H3K27me3 and VEGF is associated with poor prognosis in patients with synovial sarcoma.
Diao Y, Zhang P, Dai R, Xu J, Feng H
Pathol Res Pract 2018 Jul;214(7):974-977. Epub 2018 May 20 doi: 10.1016/j.prp.2018.05.015. PMID: 29803658
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Clinical prediction guides

Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Clinical Characteristics, Prognostic Factor and a Novel Dynamic Prediction Model for Overall Survival of Elderly Patients With Chondrosarcoma: A Population-Based Study.
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
Comparison of the AJCC, MSTS, and Modified Spanier Systems for Clinical and Pathologic Staging of Osteosarcoma.
Cates JM
Am J Surg Pathol 2017 Mar;41(3):405-413. doi: 10.1097/PAS.0000000000000774. PMID: 28195881

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