U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sarcoma by AJCC Grade

MedGen UID:
233435
•Concept ID:
C1335919
•
Neoplastic Process
Synonym: AJCC Tumor Grade in Sarcoma

Professional guidelines

PubMed

Risk Assessment of Visceral Sarcomas: A Comparative Study of 2698 Cases from the SEER Database.
Dashti NK, Cates JMM
Ann Surg Oncol 2021 Oct;28(11):6852-6860. Epub 2021 Feb 4 doi: 10.1245/s10434-020-09576-2. PMID: 33538930
Management and outcomes among patients with sarcomatoid hepatocellular carcinoma: A population-based analysis.
Wu L, Tsilimigras DI, Farooq A, Hyer JM, Merath K, Paredes AZ, Mehta R, Sahara K, Shen F, Pawlik TM
Cancer 2019 Nov 1;125(21):3767-3775. Epub 2019 Jul 12 doi: 10.1002/cncr.32396. PMID: 31299092

Recent clinical studies

Etiology

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Clinical Characteristics, Prognostic Factor and a Novel Dynamic Prediction Model for Overall Survival of Elderly Patients With Chondrosarcoma: A Population-Based Study.
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
An Evaluation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) Staging System for Retroperitoneal Sarcomas Using the National Cancer Data Base (NCDB): Does Size Matter?
Fisher SB, Chiang YJ, Feig BW, Cormier JN, Hunt KK, Torres KE, Roland CL
Am J Clin Oncol 2019 Feb;42(2):160-165. doi: 10.1097/COC.0000000000000486. PMID: 30394881Free PMC Article
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC
J Surg Oncol 2016 Oct;114(5):557-563. Epub 2016 Jul 4 doi: 10.1002/jso.24352. PMID: 27378102
Staging soft tissue sarcoma: evolution and change.
Kotilingam D, Lev DC, Lazar AJ, Pollock RE
CA Cancer J Clin 2006 Sep-Oct;56(5):282-91; quiz 314-5. doi: 10.3322/canjclin.56.5.282. PMID: 17005597

Diagnosis

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.
Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Clinical Characteristics, Prognostic Factor and a Novel Dynamic Prediction Model for Overall Survival of Elderly Patients With Chondrosarcoma: A Population-Based Study.
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Staging soft tissue sarcoma: evolution and change.
Kotilingam D, Lev DC, Lazar AJ, Pollock RE
CA Cancer J Clin 2006 Sep-Oct;56(5):282-91; quiz 314-5. doi: 10.3322/canjclin.56.5.282. PMID: 17005597
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Therapy

Development and validation of a nomogram for predicting prognosis of high-grade chondrosarcoma: A surveillance, epidemiology, and end results-based population analysis.
Sun Y, Ouyang C, Zhang Y, Li Y, Liu Y, Jiang M, Nong L, Gao G
J Orthop Surg (Hong Kong) 2023 May-Aug;31(2):10225536231174255. doi: 10.1177/10225536231174255. PMID: 37147017
Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Clinical Characteristics, Prognostic Factor and a Novel Dynamic Prediction Model for Overall Survival of Elderly Patients With Chondrosarcoma: A Population-Based Study.
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
When to consider adjuvant/neoadjuvant therapy for adult soft-tissue sarcoma.
Bramwell V
Oncology (Williston Park) 2007 Apr;21(4):511-4. PMID: 17474349

Prognosis

Clinical Characteristics, Prognostic Factor and a Novel Dynamic Prediction Model for Overall Survival of Elderly Patients With Chondrosarcoma: A Population-Based Study.
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
An Evaluation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) Staging System for Retroperitoneal Sarcomas Using the National Cancer Data Base (NCDB): Does Size Matter?
Fisher SB, Chiang YJ, Feig BW, Cormier JN, Hunt KK, Torres KE, Roland CL
Am J Clin Oncol 2019 Feb;42(2):160-165. doi: 10.1097/COC.0000000000000486. PMID: 30394881Free PMC Article
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC
J Surg Oncol 2016 Oct;114(5):557-563. Epub 2016 Jul 4 doi: 10.1002/jso.24352. PMID: 27378102
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Clinical prediction guides

Prognostic nomogram in patients with epithelioid sarcoma: A SEER-based study.
Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C
Cancer Med 2023 Feb;12(3):3079-3088. Epub 2022 Sep 8 doi: 10.1002/cam4.5230. PMID: 36073670Free PMC Article
Clinical Characteristics, Prognostic Factor and a Novel Dynamic Prediction Model for Overall Survival of Elderly Patients With Chondrosarcoma: A Population-Based Study.
Tong Y, Cui Y, Jiang L, Pi Y, Gong Y, Zhao D
Front Public Health 2022;10:901680. Epub 2022 Jun 30 doi: 10.3389/fpubh.2022.901680. PMID: 35844853Free PMC Article
Evidence-based Tumor Staging of Skeletal Chondrosarcoma.
Compton ML, Cates JMM
Am J Surg Pathol 2020 Jan;44(1):111-119. doi: 10.1097/PAS.0000000000001397. PMID: 31651521
An Evaluation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) Staging System for Retroperitoneal Sarcomas Using the National Cancer Data Base (NCDB): Does Size Matter?
Fisher SB, Chiang YJ, Feig BW, Cormier JN, Hunt KK, Torres KE, Roland CL
Am J Clin Oncol 2019 Feb;42(2):160-165. doi: 10.1097/COC.0000000000000486. PMID: 30394881Free PMC Article
Staging soft tissue sarcoma: evolution and change.
Kotilingam D, Lev DC, Lazar AJ, Pollock RE
CA Cancer J Clin 2006 Sep-Oct;56(5):282-91; quiz 314-5. doi: 10.3322/canjclin.56.5.282. PMID: 17005597

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...