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Childhood Benign Brain Neoplasm

MedGen UID:
231425
•Concept ID:
C1332482
•
Neoplastic Process
Synonyms: Benign Childhood Brain Neoplasm; Benign Childhood Brain Tumor; Benign Childhood Neoplasm of Brain; Benign Childhood Neoplasm of the Brain; Benign Childhood Tumor of Brain; Benign Childhood Tumor of the Brain; Benign Pediatric Brain Neoplasm; Benign Pediatric Brain Tumor; Benign Pediatric Neoplasm of Brain; Benign Pediatric Neoplasm of the Brain; Benign Pediatric Tumor of Brain; Benign Pediatric Tumor of the Brain

Definition

A childhood neoplasm that arises from the brain and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.
Sun LR, Lynch JK
Neurotherapeutics 2023 Apr;20(3):633-654. Epub 2023 Apr 18 doi: 10.1007/s13311-023-01373-5. PMID: 37072548Free PMC Article
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Etiology

Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Risk factors for childhood and adult primary brain tumors.
Ostrom QT, Adel Fahmideh M, Cote DJ, Muskens IS, Schraw JM, Scheurer ME, Bondy ML
Neuro Oncol 2019 Nov 4;21(11):1357-1375. doi: 10.1093/neuonc/noz123. PMID: 31301133Free PMC Article
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Medulloblastoma.
Millard NE, De Braganca KC
J Child Neurol 2016 Oct;31(12):1341-53. Epub 2015 Sep 2 doi: 10.1177/0883073815600866. PMID: 26336203Free PMC Article
Pediatric brain tumors.
Wells EM, Packer RJ
Continuum (Minneap Minn) 2015 Apr;21(2 Neuro-oncology):373-96. doi: 10.1212/01.CON.0000464176.96311.d1. PMID: 25837902

Diagnosis

Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Risk factors for childhood and adult primary brain tumors.
Ostrom QT, Adel Fahmideh M, Cote DJ, Muskens IS, Schraw JM, Scheurer ME, Bondy ML
Neuro Oncol 2019 Nov 4;21(11):1357-1375. doi: 10.1093/neuonc/noz123. PMID: 31301133Free PMC Article
Pediatric Brain Tumors.
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070
Medulloblastoma.
Millard NE, De Braganca KC
J Child Neurol 2016 Oct;31(12):1341-53. Epub 2015 Sep 2 doi: 10.1177/0883073815600866. PMID: 26336203Free PMC Article
Pediatric brain tumors.
Wells EM, Packer RJ
Continuum (Minneap Minn) 2015 Apr;21(2 Neuro-oncology):373-96. doi: 10.1212/01.CON.0000464176.96311.d1. PMID: 25837902

Therapy

Molecular-Targeted Therapy for Childhood Brain Tumors: A Moving Target.
Packer RJ, Kilburn L
J Child Neurol 2020 Oct;35(12):791-798. Epub 2020 Jun 18 doi: 10.1177/0883073820931635. PMID: 32552173
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials.
Walker DA, Meijer L, Coyle B, Halsey C
Lancet Child Adolesc Health 2020 Mar;4(3):242-250. Epub 2020 Jan 17 doi: 10.1016/S2352-4642(19)30333-5. PMID: 31958415
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591

Prognosis

Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Medulloblastoma.
Millard NE, De Braganca KC
J Child Neurol 2016 Oct;31(12):1341-53. Epub 2015 Sep 2 doi: 10.1177/0883073815600866. PMID: 26336203Free PMC Article
Pediatric brain tumors.
Wells EM, Packer RJ
Continuum (Minneap Minn) 2015 Apr;21(2 Neuro-oncology):373-96. doi: 10.1212/01.CON.0000464176.96311.d1. PMID: 25837902

Clinical prediction guides

Posterior fossa tumors in children: current insights.
Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors.
Foster JB, Griffin C, Rokita JL, Stern A, Brimley C, Rathi K, Lane MV, Buongervino SN, Smith T, Madsen PJ, Martinez D, Delaidelli A, Sorensen PH, Wechsler-Reya RJ, Karikó K, Storm PB, Barrett DM, Resnick AC, Maris JM, Bosse KR
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2021-004450. PMID: 36167467Free PMC Article
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Molecular genetics of gliomas.
Appin CL, Brat DJ
Cancer J 2014 Jan-Feb;20(1):66-72. doi: 10.1097/PPO.0000000000000020. PMID: 24445767
Childhood brain tumors.
Sklar CA
J Pediatr Endocrinol Metab 2002 May;15 Suppl 2:669-73. doi: 10.1515/jpem.2002.15.s2.669. PMID: 12092679

Recent systematic reviews

Delay in the diagnosis of paediatric brain tumours: a systematic review.
Kehoe K, Sivaguru H, Coulter I, Cowie C
Childs Nerv Syst 2023 Aug;39(8):2053-2063. Epub 2023 Jun 19 doi: 10.1007/s00381-023-06022-y. PMID: 37336792
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis.
Lassaletta Á, Morales JS, Valenzuela PL, Esteso B, Kahalley LS, Mabbott DJ, Unnikrishnan S, Panizo E, Calvo F
World J Pediatr 2023 Aug;19(8):727-740. Epub 2023 May 8 doi: 10.1007/s12519-023-00726-6. PMID: 37154861Free PMC Article
Overweight, obesity and adiposity in survivors of childhood brain tumours: a systematic review and meta-analysis.
Wang KW, Fleming A, Johnston DL, Zelcer SM, Rassekh SR, Ladhani S, Socha A, Shinuda J, Jaber S, Burrow S, Singh SK, Banfield L, de Souza RJ, Thabane L, Samaan MC
Clin Obes 2018 Feb;8(1):55-67. Epub 2017 Oct 11 doi: 10.1111/cob.12224. PMID: 29024558
Childhood Brain Tumors: a Systematic Review of the Structural Neuroimaging Literature.
Ailion AS, Hortman K, King TZ
Neuropsychol Rev 2017 Sep;27(3):220-244. Epub 2017 Jun 23 doi: 10.1007/s11065-017-9352-6. PMID: 28646252
Neuropsychiatric presentations and outcomes in children and adolescents with primary brain tumours: Systematic review.
Zyrianova Y, Alexander L, Faruqui R
Brain Inj 2016;30(1):1-9. Epub 2015 Nov 5 doi: 10.3109/02699052.2015.1075590. PMID: 26536821

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