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Benign breast phyllodes tumor

MedGen UID:
231438
Concept ID:
C1332533
Neoplastic Process
Synonyms: Benign Breast Phyllodes Tumor; benign breast phyllodes tumor; benign cystosarcoma phyllodes; Benign phyllodes neoplasm of breast; Benign Phyllodes Neoplasm of Breast; benign phyllodes neoplasm of breast; Benign Phyllodes Neoplasm of the Breast; benign phyllodes neoplasm of the breast; Benign Phyllodes Tumor of Breast; benign phyllodes tumor of breast; Benign Phyllodes Tumor of the Breast; benign phyllodes tumor of the breast; benign phyllodes tumour of breast; benign phyllodes tumour of the breast; BPT; Breast Benign Phyllodes Neoplasm; breast benign phyllodes neoplasm; breast phyllodes tumor, benign; cystosarcoma phyllode; cystosarcoma phyllode of the breast; cystosarcoma phyllodes; cystosarcoma phyllodes NOS (morphologic abnormality); cystosarcoma phylloide; cystosarcoma phylloide of the breast; phyllode tumor of the breast; phyllode tumour of the breast; Phyllodes tumor of the breast; phylloide tumor of the breast; phylloide tumour of the breast
SNOMED CT: Benign phyllodes neoplasm of breast (720344007)
 
Monarch Initiative: MONDO:0015871
Orphanet: ORPHA180261

Definition

A rare fibroepithelial neoplasm usually presenting in adult females with a well circumscribed mobile masses that grow rapidly and sometimes with additional non-specific symptoms such as dilated skin veins, nipple retraction, skin ulcers, palpable axillary lymphadenopathy or blue discoloration of the skin. The neoplasm can be benign or malignant. [from ORDO]

Professional guidelines

PubMed

Ofri A, Stuart KE, Chan B, Mak C, Warrier S, Bhadri V, Mander-Jones T, O'Toole S
Surgeon 2022 Dec;20(6):e355-e365. Epub 2022 Feb 9 doi: 10.1016/j.surge.2022.01.004. PMID: 35148937
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Recent clinical studies

Etiology

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Diagnosis

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Papas Y, Asmar AE, Ghandour F, Hajj I
Breast J 2020 Feb;26(2):240-244. Epub 2019 Sep 3 doi: 10.1111/tbj.13523. PMID: 31478587
Chugh R, Baker L
Oncology (Williston Park) 2004 May;18(5):665-73; discussion 673-6. PMID: 15209192
Khan SA, Badve S
Curr Treat Options Oncol 2001 Apr;2(2):139-47. doi: 10.1007/s11864-001-0056-y. PMID: 12057132
Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256

Prognosis

Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Parker SJ, Harries SA
Postgrad Med J 2001 Jul;77(909):428-35. doi: 10.1136/pmj.77.909.428. PMID: 11423590Free PMC Article

Clinical prediction guides

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Recent systematic reviews

Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Toussaint A, Piaget-Rossel R, Stormacq C, Mathevet P, Lepigeon K, Taffé P
Breast Cancer Res Treat 2021 Jan;185(1):21-37. Epub 2020 Sep 15 doi: 10.1007/s10549-020-05924-8. PMID: 32935237
Thind A, Patel B, Thind K, Isherwood J, Phillips B, Dhaliwal K, Remoundos DD
Ann R Coll Surg Engl 2020 Mar;102(3):165-173. Epub 2020 Jan 10 doi: 10.1308/rcsann.2019.0140. PMID: 31918563Free PMC Article
Lu Y, Chen Y, Zhu L, Cartwright P, Song E, Jacobs L, Chen K
Ann Surg Oncol 2019 May;26(5):1263-1275. Epub 2019 Jan 7 doi: 10.1245/s10434-018-07134-5. PMID: 30617873

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