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Benign testicular sertoli cell tumor

MedGen UID:
231945
•Concept ID:
C1332540
•
Neoplastic Process
Synonyms: Benign Sertoli Cell Neoplasm of Testis; benign sertoli cell neoplasm of testis; Benign Sertoli Cell Neoplasm of the Testis; benign sertoli cell neoplasm of the testis; Benign Sertoli Cell Tumor of Testis; benign sertoli cell tumor of testis; Benign Sertoli Cell Tumor of the Testis; benign sertoli cell tumor of the testis; benign sertoli cell tumour of testis; benign sertoli cell tumour of the testis; Benign Testicular Sertoli Cell Neoplasm; benign testicular sertoli cell neoplasm; Benign Testicular Sertoli Cell Tumor; benign testicular sertoli cell tumor
 
Monarch Initiative: MONDO:0020813

Definition

A non-metastasizing sex cord-stromal tumor that arises from the testis. Morphologically, it is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. [from NCI]

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the Prepubertal Testis Tumor Registry.
Ross JH, Rybicki L, Kay R
J Urol 2002 Oct;168(4 Pt 2):1675-8; discussion 1678-9. doi: 10.1097/01.ju.0000030749.27823.f5. PMID: 12352332
Management of testicular masses incidentally discovered by ultrasound.
Horstman WG, Haluszka MM, Burkhard TK
J Urol 1994 May;151(5):1263-5. doi: 10.1016/s0022-5347(17)35227-8. PMID: 8158772

Recent clinical studies

Etiology

Testicular Lesions in Infertile Men.
Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features.
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Conservative parenchymal surgery in testicular tumors.
Ibarra Rodríguez MR, Murcia Pascual FJ, Vázquez Rueda F, de Lucio Rodríguez M, Siu Uribe A, Ramnarine Sánchez SD, Escassi Gil A, Paredes Esteban RM
Cir Pediatr 2021 Jan 1;34(1):15-19. PMID: 33507639
Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.
Paffenholz P, Held L, Loosen SH, Pfister D, Heidenreich A
J Urol 2018 Aug;200(2):353-360. Epub 2018 Mar 9 doi: 10.1016/j.juro.2018.03.007. PMID: 29530784
Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature.
Kratzer SS, Ulbright TM, Talerman A, Srigley JR, Roth LM, Wahle GR, Moussa M, Stephens JK, Millos A, Young RH
Am J Surg Pathol 1997 Nov;21(11):1271-80. doi: 10.1097/00000478-199711000-00002. PMID: 9351565

Diagnosis

Testicular Lesions in Infertile Men.
Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome.
Golmard L, Vasta LM, Duflos V, Corsini C, Dubois d'Enghien C, McMaster ML, Harney LA, Carr AG, Ling A, Dijoud F, Gauthier A, Miettinen M, Cost NG, Gauthier-Villars M, Orbach D, Irtan S, Haouy S, Schultz KA, Stoppa-Lyonnet D, Coupier I, Stewart DR, Sirvent N
J Med Genet 2022 Apr;59(4):346-350. Epub 2021 Mar 29 doi: 10.1136/jmedgenet-2020-107434. PMID: 33782093Free PMC Article
Conservative parenchymal surgery in testicular tumors.
Ibarra Rodríguez MR, Murcia Pascual FJ, Vázquez Rueda F, de Lucio Rodríguez M, Siu Uribe A, Ramnarine Sánchez SD, Escassi Gil A, Paredes Esteban RM
Cir Pediatr 2021 Jan 1;34(1):15-19. PMID: 33507639
Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article
Benign testicular tumors.
Chang SY, Ma CP, Tzeng CC
Eur Urol 1987;13(4):242-5. doi: 10.1159/000472787. PMID: 3308471

Therapy

Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone.
Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F
Horm Res 2005;63(5):252-6. Epub 2005 Jun 9 doi: 10.1159/000086325. PMID: 15947469
Feminizing Sertoli cell tumor associated with Peutz-Jeghers syndrome.
Alikasifoglu A, Gonc EN, Akcoren Z, Kale G, Ciftci AO, Senocak ME, Yordam N
J Pediatr Endocrinol Metab 2002 Apr;15(4):449-52. doi: 10.1515/jpem.2002.15.4.449. PMID: 12008693

Prognosis

Ovarian Sertoli Cell Tumor with Immature Prepubertal-like Sertoli Cell Component: A Case Report and Literature Review.
Bužinskienė D, Šidlovska E, Vilutytė G
Medicina (Kaunas) 2022 Nov 13;58(11) doi: 10.3390/medicina58111638. PMID: 36422177Free PMC Article
Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features.
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.
Paffenholz P, Held L, Loosen SH, Pfister D, Heidenreich A
J Urol 2018 Aug;200(2):353-360. Epub 2018 Mar 9 doi: 10.1016/j.juro.2018.03.007. PMID: 29530784
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908
Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature.
Kratzer SS, Ulbright TM, Talerman A, Srigley JR, Roth LM, Wahle GR, Moussa M, Stephens JK, Millos A, Young RH
Am J Surg Pathol 1997 Nov;21(11):1271-80. doi: 10.1097/00000478-199711000-00002. PMID: 9351565

Clinical prediction guides

Phenotype evolution and health issues of adults with Beckwith-Wiedemann syndrome.
Gazzin A, Carli D, Sirchia F, Molinatto C, Cardaropoli S, Palumbo G, Zampino G, Ferrero GB, Mussa A
Am J Med Genet A 2019 Sep;179(9):1691-1702. Epub 2019 Jul 24 doi: 10.1002/ajmg.a.61301. PMID: 31339634
Case Report of Misleading Features of a Rare Sertoli Cell Testicular Tumor.
Anglickis M, Stulpinas R, Anglickienė G, Gabrilevičius J, Jaškevičius A
Medicina (Kaunas) 2019 May 20;55(5) doi: 10.3390/medicina55050170. PMID: 31137577Free PMC Article
Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.
Paffenholz P, Held L, Loosen SH, Pfister D, Heidenreich A
J Urol 2018 Aug;200(2):353-360. Epub 2018 Mar 9 doi: 10.1016/j.juro.2018.03.007. PMID: 29530784
Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies.
Munari E, Chaux A, Vaghasia AM, Taheri D, Karram S, Bezerra SM, Gonzalez Roibon N, Nelson WG, Yegnasubramanian S, Netto GJ, Haffner MC
PLoS One 2016;11(1):e0146302. Epub 2016 Jan 19 doi: 10.1371/journal.pone.0146302. PMID: 26785262Free PMC Article
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

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