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Benign testicular sertoli cell tumor

MedGen UID:
231945
•Concept ID:
C1332540
•
Neoplastic Process
Synonyms: Benign Sertoli Cell Neoplasm of Testis; benign sertoli cell neoplasm of testis; Benign Sertoli Cell Neoplasm of the Testis; benign sertoli cell neoplasm of the testis; Benign Sertoli Cell Tumor of Testis; benign sertoli cell tumor of testis; Benign Sertoli Cell Tumor of the Testis; benign sertoli cell tumor of the testis; benign sertoli cell tumour of testis; benign sertoli cell tumour of the testis; Benign Testicular Sertoli Cell Neoplasm; benign testicular sertoli cell neoplasm; Benign Testicular Sertoli Cell Tumor; benign testicular sertoli cell tumor
 
Monarch Initiative: MONDO:0020813

Definition

A non-metastasizing sex cord-stromal tumor that arises from the testis. Morphologically, it is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. [from NCI]

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the Prepubertal Testis Tumor Registry.
Ross JH, Rybicki L, Kay R
J Urol 2002 Oct;168(4 Pt 2):1675-8; discussion 1678-9. doi: 10.1097/01.ju.0000030749.27823.f5. PMID: 12352332
Management of testicular masses incidentally discovered by ultrasound.
Horstman WG, Haluszka MM, Burkhard TK
J Urol 1994 May;151(5):1263-5. doi: 10.1016/s0022-5347(17)35227-8. PMID: 8158772

Recent clinical studies

Etiology

Testicular Lesions in Infertile Men.
Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features.
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Conservative parenchymal surgery in testicular tumors.
Ibarra Rodríguez MR, Murcia Pascual FJ, Vázquez Rueda F, de Lucio Rodríguez M, Siu Uribe A, Ramnarine Sánchez SD, Escassi Gil A, Paredes Esteban RM
Cir Pediatr 2021 Jan 1;34(1):15-19. PMID: 33507639
Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.
Paffenholz P, Held L, Loosen SH, Pfister D, Heidenreich A
J Urol 2018 Aug;200(2):353-360. Epub 2018 Mar 9 doi: 10.1016/j.juro.2018.03.007. PMID: 29530784
Organ-sparing surgery for testicular tumours.
Djaladat H
Curr Opin Urol 2015 Mar;25(2):116-20. doi: 10.1097/MOU.0000000000000150. PMID: 25581544

Diagnosis

Testicular Lesions in Infertile Men.
Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome.
Golmard L, Vasta LM, Duflos V, Corsini C, Dubois d'Enghien C, McMaster ML, Harney LA, Carr AG, Ling A, Dijoud F, Gauthier A, Miettinen M, Cost NG, Gauthier-Villars M, Orbach D, Irtan S, Haouy S, Schultz KA, Stoppa-Lyonnet D, Coupier I, Stewart DR, Sirvent N
J Med Genet 2022 Apr;59(4):346-350. Epub 2021 Mar 29 doi: 10.1136/jmedgenet-2020-107434. PMID: 33782093Free PMC Article
Conservative parenchymal surgery in testicular tumors.
Ibarra Rodríguez MR, Murcia Pascual FJ, Vázquez Rueda F, de Lucio Rodríguez M, Siu Uribe A, Ramnarine Sánchez SD, Escassi Gil A, Paredes Esteban RM
Cir Pediatr 2021 Jan 1;34(1):15-19. PMID: 33507639
Organ-sparing surgery for testicular tumours.
Djaladat H
Curr Opin Urol 2015 Mar;25(2):116-20. doi: 10.1097/MOU.0000000000000150. PMID: 25581544
Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article

Therapy

Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone.
Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F
Horm Res 2005;63(5):252-6. Epub 2005 Jun 9 doi: 10.1159/000086325. PMID: 15947469
Feminizing Sertoli cell tumor associated with Peutz-Jeghers syndrome.
Alikasifoglu A, Gonc EN, Akcoren Z, Kale G, Ciftci AO, Senocak ME, Yordam N
J Pediatr Endocrinol Metab 2002 Apr;15(4):449-52. doi: 10.1515/jpem.2002.15.4.449. PMID: 12008693

Prognosis

Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features.
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.
Paffenholz P, Held L, Loosen SH, Pfister D, Heidenreich A
J Urol 2018 Aug;200(2):353-360. Epub 2018 Mar 9 doi: 10.1016/j.juro.2018.03.007. PMID: 29530784
The prevalence of DICER1 pathogenic variation in population databases.
Kim J, Field A, Schultz KAP, Hill DA, Stewart DR
Int J Cancer 2017 Nov 15;141(10):2030-2036. Epub 2017 Aug 21 doi: 10.1002/ijc.30907. PMID: 28748527Free PMC Article
Pathologic Risk Factors in Pediatric and Adolescent Patients With Clinical Stage I Testicular Stromal Tumors.
Rove KO, Maroni PD, Cost CR, Fairclough DL, Giannarini G, Harris AK, Schultz KA, Cost NG
J Pediatr Hematol Oncol 2015 Nov;37(8):e441-6. doi: 10.1097/MPH.0000000000000445. PMID: 26479987
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

Clinical prediction guides

The sclerosing sertoli cell tumor of the testis: a case report.
Tang X, Hu Y, Zhou H, Zhou Y
Diagn Pathol 2023 May 15;18(1):61. doi: 10.1186/s13000-023-01351-7. PMID: 37189109Free PMC Article
Phenotype evolution and health issues of adults with Beckwith-Wiedemann syndrome.
Gazzin A, Carli D, Sirchia F, Molinatto C, Cardaropoli S, Palumbo G, Zampino G, Ferrero GB, Mussa A
Am J Med Genet A 2019 Sep;179(9):1691-1702. Epub 2019 Jul 24 doi: 10.1002/ajmg.a.61301. PMID: 31339634
Testis Sparing Surgery for Benign Testicular Masses: Diagnostics and Therapeutic Approaches.
Paffenholz P, Held L, Loosen SH, Pfister D, Heidenreich A
J Urol 2018 Aug;200(2):353-360. Epub 2018 Mar 9 doi: 10.1016/j.juro.2018.03.007. PMID: 29530784
Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies.
Munari E, Chaux A, Vaghasia AM, Taheri D, Karram S, Bezerra SM, Gonzalez Roibon N, Nelson WG, Yegnasubramanian S, Netto GJ, Haffner MC
PLoS One 2016;11(1):e0146302. Epub 2016 Jan 19 doi: 10.1371/journal.pone.0146302. PMID: 26785262Free PMC Article
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

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