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Congenital mesoblastic nephroma

MedGen UID:
232058
•Concept ID:
C1332965
•
Neoplastic Process
Synonyms: Congenital Mesoblastic Nephroma; Congenital Mesoblastic Nephromas; Mesoblastic Nephroma, Congenital; Mesoblastic Nephromas, Congenital; Nephroma, Congenital Mesoblastic; Nephromas, Congenital Mesoblastic
 
HPO: HP:0100881
Monarch Initiative: MONDO:0017043
Orphanet: ORPHA2665

Definition

Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital mesoblastic nephroma

Professional guidelines

PubMed

Congenital mesoblastic nephroma: review of current management and outcomes in a single centre.
Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: Experience at a single center in China.
Chen YX, Huang C, He QM, Wang Z, Huang L, Wang HY, Mei SS, Chai CW, Zhang GL, Zhong W, Li DZ
Prenat Diagn 2021 May;41(6):766-771. Epub 2021 Apr 5 doi: 10.1002/pd.5942. PMID: 33782977
Incidence, treatment, and outcomes of primary and recurrent Non-Wilms renal tumors in children: Report of 109 patients treated at a single institution.
Qureshi SS, Bhagat M, Verma K, Yadav S, Prasad M, Vora T, Chinnaswamy G, Amin N, Smriti V, Baheti A, Laskar S, Khanna N, Ramadwar M, Shah S
J Pediatr Urol 2020 Aug;16(4):475.e1-475.e9. Epub 2020 Jun 5 doi: 10.1016/j.jpurol.2020.05.168. PMID: 32620510

Recent clinical studies

Etiology

Congenital mesoblastic nephroma: review of current management and outcomes in a single centre.
Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
Imaging manifestations of congenital mesoblastic nephroma.
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
Congenital mesoblastic nephroma: a single-centre series.
Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B
Ann R Coll Surg Engl 2020 Jan;102(1):67-70. Epub 2019 Sep 11 doi: 10.1308/rcsann.2019.0111. PMID: 31508997Free PMC Article
Congenital mesoblastic nephroma 50 years after its recognition: A narrative review.
Gooskens SL, Houwing ME, Vujanic GM, Dome JS, Diertens T, Coulomb-l'Herminé A, Godzinski J, Pritchard-Jones K, Graf N, van den Heuvel-Eibrink MM
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2017 Jan 26 doi: 10.1002/pbc.26437. PMID: 28124468
Ultrastructure of cellular congenital mesoblastic nephroma.
O'Malley DP, Mierau GW, Beckwith JB, Weeks DA
Ultrastruct Pathol 1996 Sep-Oct;20(5):417-27. doi: 10.3109/01913129609016344. PMID: 8883325

Diagnosis

Mesenchymal neoplasms with NTRK and other kinase gene alterations.
Davis JL, Al-Ibraheemi A, Rudzinski ER, Surrey LF
Histopathology 2022 Jan;80(1):4-18. doi: 10.1111/his.14443. PMID: 34958503
Neonatal Renal Tumors.
Sze SK
Clin Perinatol 2021 Mar;48(1):71-81. Epub 2021 Jan 11 doi: 10.1016/j.clp.2020.11.004. PMID: 33583508
Imaging manifestations of congenital mesoblastic nephroma.
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
Neonatal solid tumors.
Chandrasekaran A
Pediatr Neonatol 2018 Feb;59(1):65-70. Epub 2017 Jul 11 doi: 10.1016/j.pedneo.2016.12.007. PMID: 28736178
Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand?
Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451

Therapy

Neonatal congenital mesoblastic nephroma that caused respiratory oncologic emergency early after birth: a case report.
Kato H, Mitani Y, Goda T, Yamaue H
BMC Pediatr 2022 Mar 17;22(1):139. doi: 10.1186/s12887-022-03210-8. PMID: 35300628Free PMC Article
Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma: A case report and management of neonatal hypercalcemia: Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma.
Tanné C, Pracros JP, Dijoud F, Mure PY, Bordet F, Duncan A, Bacchetta J
Arch Pediatr 2022 Feb;29(2):153-156. Epub 2022 Jan 14 doi: 10.1016/j.arcped.2021.11.013. PMID: 35039190
Congenital mesoblastic nephroma: a single-centre series.
Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B
Ann R Coll Surg Engl 2020 Jan;102(1):67-70. Epub 2019 Sep 11 doi: 10.1308/rcsann.2019.0111. PMID: 31508997Free PMC Article
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.
Vokuhl C, Nourkami-Tutdibi N, Furtwängler R, Gessler M, Graf N, Leuschner I
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26925. PMID: 29286563

Prognosis

Report and follow-up on two new patients with congenital mesoblastic nephroma.
Serra G, Cimador M, Giuffrè M, Insinga V, Montante C, Pensabene M, Piro E, Salerno S, Schierz IAM, Corsello G
Ital J Pediatr 2023 Sep 19;49(1):124. doi: 10.1186/s13052-023-01523-7. PMID: 37726782Free PMC Article
Congenital mesoblastic nephroma: review of current management and outcomes in a single centre.
Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.
Vokuhl C, Nourkami-Tutdibi N, Furtwängler R, Gessler M, Graf N, Leuschner I
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26925. PMID: 29286563
Neonatal solid tumors.
Chandrasekaran A
Pediatr Neonatol 2018 Feb;59(1):65-70. Epub 2017 Jul 11 doi: 10.1016/j.pedneo.2016.12.007. PMID: 28736178
Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand?
Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451

Clinical prediction guides

Report and follow-up on two new patients with congenital mesoblastic nephroma.
Serra G, Cimador M, Giuffrè M, Insinga V, Montante C, Pensabene M, Piro E, Salerno S, Schierz IAM, Corsello G
Ital J Pediatr 2023 Sep 19;49(1):124. doi: 10.1186/s13052-023-01523-7. PMID: 37726782Free PMC Article
Imaging manifestations of congenital mesoblastic nephroma.
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Genetics of pediatric renal tumors.
Royer-Pokora B
Pediatr Nephrol 2013 Jan;28(1):13-23. Epub 2012 Mar 30 doi: 10.1007/s00467-012-2146-4. PMID: 22461142
Ultrastructure of cellular congenital mesoblastic nephroma.
O'Malley DP, Mierau GW, Beckwith JB, Weeks DA
Ultrastruct Pathol 1996 Sep-Oct;20(5):417-27. doi: 10.3109/01913129609016344. PMID: 8883325

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