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Childhood kidney Wilms tumor

MedGen UID:
232073
•Concept ID:
C1333015
•
Neoplastic Process
Synonyms: Childhood Kidney Nephroblastoma; Childhood Kidney Wilms Tumor; childhood kidney Wilms tumor; Childhood Renal Wilms Tumor; childhood renal Wilms tumor; childhood renal Wilms tumour; Childhood Renal Wilms' Tumor; childhood renal Wilms' tumor; childhood renal Wilms' tumour; childhood Wilms tumor; childhood Wilms tumour
 
Monarch Initiative: MONDO:0024676

Definition

A Wilms tumor of the kidney which occurs in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood kidney Wilms tumor

Professional guidelines

PubMed

Cardiomyopathy in Children: Classification and Diagnosis: A Scientific Statement From the American Heart Association.
Lipshultz SE, Law YM, Asante-Korang A, Austin ED, Dipchand AI, Everitt MD, Hsu DT, Lin KY, Price JF, Wilkinson JD, Colan SD
Circulation 2019 Jul 2;140(1):e9-e68. Epub 2019 May 28 doi: 10.1161/CIR.0000000000000682. PMID: 31132865
Pharmacotherapeutic Management of Wilms Tumor: An Update.
Oostveen RM, Pritchard-Jones K
Paediatr Drugs 2019 Feb;21(1):1-13. doi: 10.1007/s40272-018-0323-z. PMID: 30604241
Management of Wilms Tumor: ICMR Consensus Document.
Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, Kapoor G, Chinnaswamy G, Radhakrishnan V, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):437-445. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2305-5. PMID: 28367612

Recent clinical studies

Etiology

Wilms Tumor.
Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707
Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges.
Libes J, Hol J, Neto JCA, Vallance KL, Tinteren HV, Benedetti DJ, Villar GLR, Duncan C, Ehrlich PF
Pediatr Blood Cancer 2023 May;70 Suppl 2:e30343. doi: 10.1002/pbc.30343. PMID: 37096796
Wilms tumour.
Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, Gessler M, Maschietto M, Behjati S, Polanco A, Paintsil V, Luna-Fineman S, Pritchard-Jones K
Nat Rev Dis Primers 2021 Oct 14;7(1):75. doi: 10.1038/s41572-021-00308-8. PMID: 34650095
Wilms Tumor: Challenges and Newcomers in Prognosis.
Parsons LN
Surg Pathol Clin 2020 Dec;13(4):683-693. doi: 10.1016/j.path.2020.08.007. PMID: 33183727
Intra-tumor genetic heterogeneity in Wilms tumor samples.
de Sá Pereira BM, Azevedo RM, Aguirre Neto JC, Menezes CF, Rodrigues KE, Faria PA, Camargo B, Maschietto M
Rev Assoc Med Bras (1992) 2019 Dec;65(12):1496-1501. doi: 10.1590/1806-9282.65.12.1496. PMID: 31994632

Diagnosis

Wilms Tumor.
Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707
Wilms tumour.
Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, Gessler M, Maschietto M, Behjati S, Polanco A, Paintsil V, Luna-Fineman S, Pritchard-Jones K
Nat Rev Dis Primers 2021 Oct 14;7(1):75. doi: 10.1038/s41572-021-00308-8. PMID: 34650095
Wilms Tumor: Challenges and Newcomers in Prognosis.
Parsons LN
Surg Pathol Clin 2020 Dec;13(4):683-693. doi: 10.1016/j.path.2020.08.007. PMID: 33183727
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J
Nat Commun 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. PMID: 32161258Free PMC Article
Renal dysplasia.
Chen RY, Chang H
Arch Pathol Lab Med 2015 Apr;139(4):547-51. doi: 10.5858/arpa.2013-0660-RS. PMID: 25822765

Therapy

Clinical Care for People Who Survive Childhood Cancer: A Review.
Bhatia S, Tonorezos ES, Landier W
JAMA 2023 Sep 26;330(12):1175-1186. doi: 10.1001/jama.2023.16875. PMID: 37750876
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.
Kendsersky NM, Lindsay J, Kolb EA, Smith MA, Teicher BA, Erickson SW, Earley EJ, Mosse YP, Martinez D, Pogoriler J, Krytska K, Patel K, Groff D, Tsang M, Ghilu S, Wang Y, Seaman S, Feng Y, Croix BS, Gorlick R, Kurmasheva R, Houghton PJ, Maris JM
Clin Cancer Res 2021 May 15;27(10):2938-2946. Epub 2021 Feb 22 doi: 10.1158/1078-0432.CCR-20-4221. PMID: 33619171Free PMC Article
Progress toward liquid biopsies in pediatric solid tumors.
Weiser DA, West-Szymanski DC, Fraint E, Weiner S, Rivas MA, Zhao CWT, He C, Applebaum MA
Cancer Metastasis Rev 2019 Dec;38(4):553-571. doi: 10.1007/s10555-019-09825-1. PMID: 31836951Free PMC Article
Pharmacotherapeutic Management of Wilms Tumor: An Update.
Oostveen RM, Pritchard-Jones K
Paediatr Drugs 2019 Feb;21(1):1-13. doi: 10.1007/s40272-018-0323-z. PMID: 30604241
Management of bilateral Wilms tumours.
Millar AJ, Cox S, Davidson A
Pediatr Surg Int 2017 Apr;33(4):461-469. Epub 2017 Jan 4 doi: 10.1007/s00383-016-4047-2. PMID: 28054101

Prognosis

Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
Wilms tumour.
Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, Gessler M, Maschietto M, Behjati S, Polanco A, Paintsil V, Luna-Fineman S, Pritchard-Jones K
Nat Rev Dis Primers 2021 Oct 14;7(1):75. doi: 10.1038/s41572-021-00308-8. PMID: 34650095
Wilms Tumor: Challenges and Newcomers in Prognosis.
Parsons LN
Surg Pathol Clin 2020 Dec;13(4):683-693. doi: 10.1016/j.path.2020.08.007. PMID: 33183727
Intra-tumor genetic heterogeneity in Wilms tumor samples.
de Sá Pereira BM, Azevedo RM, Aguirre Neto JC, Menezes CF, Rodrigues KE, Faria PA, Camargo B, Maschietto M
Rev Assoc Med Bras (1992) 2019 Dec;65(12):1496-1501. doi: 10.1590/1806-9282.65.12.1496. PMID: 31994632
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

Clinical prediction guides

Clinical Care for People Who Survive Childhood Cancer: A Review.
Bhatia S, Tonorezos ES, Landier W
JAMA 2023 Sep 26;330(12):1175-1186. doi: 10.1001/jama.2023.16875. PMID: 37750876
Development and Validation of a Prediction Model for Kidney Failure in Long-Term Survivors of Childhood Cancer.
Wu NL, Chen Y, Dieffenbach BV, Ehrhardt MJ, Hingorani S, Howell RM, Jefferies JL, Mulrooney DA, Oeffinger KC, Robison LL, Weil BR, Yuan Y, Yasui Y, Hudson MM, Leisenring WM, Armstrong GT, Chow EJ
J Clin Oncol 2023 Apr 20;41(12):2258-2268. Epub 2023 Feb 16 doi: 10.1200/JCO.22.01926. PMID: 36795981Free PMC Article
Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.
Kendsersky NM, Lindsay J, Kolb EA, Smith MA, Teicher BA, Erickson SW, Earley EJ, Mosse YP, Martinez D, Pogoriler J, Krytska K, Patel K, Groff D, Tsang M, Ghilu S, Wang Y, Seaman S, Feng Y, Croix BS, Gorlick R, Kurmasheva R, Houghton PJ, Maris JM
Clin Cancer Res 2021 May 15;27(10):2938-2946. Epub 2021 Feb 22 doi: 10.1158/1078-0432.CCR-20-4221. PMID: 33619171Free PMC Article
Wilms tumor genetics.
Huff V
Am J Med Genet 1998 Oct 2;79(4):260-7. doi: 10.1002/(sici)1096-8628(19981002)79:4<260::aid-ajmg6>3.0.co;2-q. PMID: 9781905

Recent systematic reviews

Maternal lifestyle characteristics and Wilms tumor risk in the offspring: A systematic review and meta-analysis.
Doganis D, Katsimpris A, Panagopoulou P, Bouka P, Bouka E, Moschovi M, Polychronopoulou S, Papakonstantinou E, Tragiannidis A, Katzilakis N, Dana H, Antoniadi K, Stefanaki K, Strantzia K, Dessypris N, Schüz J, Petridou ET
Cancer Epidemiol 2020 Aug;67:101769. Epub 2020 Jul 10 doi: 10.1016/j.canep.2020.101769. PMID: 32659726
Clinical features, treatment, and outcomes of bilateral Wilms' tumor: A systematic review and meta-analysis.
Han Q, Li K, Dong K, Xiao X, Yao W, Liu G
J Pediatr Surg 2018 Dec;53(12):2465-2469. Epub 2018 Sep 1 doi: 10.1016/j.jpedsurg.2018.08.022. PMID: 30274708
Biomarkers for Wilms Tumor: A Systematic Review.
Cone EB, Dalton SS, Van Noord M, Tracy ET, Rice HE, Routh JC
J Urol 2016 Nov;196(5):1530-1535. Epub 2016 May 31 doi: 10.1016/j.juro.2016.05.100. PMID: 27259655Free PMC Article
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006647. doi: 10.1002/14651858.CD006647.pub3. PMID: 21249679
Risk of Wilms' tumour with multicystic kidney disease: a systematic review.
Narchi H
Arch Dis Child 2005 Feb;90(2):147-9. doi: 10.1136/adc.2004.051243. PMID: 15665166Free PMC Article

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