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Adenosquamous colon carcinoma

MedGen UID:
232083
•Concept ID:
C1333082
•
Neoplastic Process
Synonyms: Adenosquamous Carcinoma of Colon; adenosquamous carcinoma of colon; Adenosquamous Carcinoma of the Colon; adenosquamous carcinoma of the colon; Adenosquamous Colon Carcinoma; adenosquamous colon carcinoma; colon adenosquamous cancer; Colon Adenosquamous Carcinoma; colon adenosquamous carcinoma; Colonic Adenosquamous Carcinoma; colonic adenosquamous carcinoma
 
Monarch Initiative: MONDO:0003554

Definition

An unusual colon carcinoma characterized by the presence of glandular and squamous carcinomatous components. The two carcinomatous components may be admixed within the tumor, or the two may appear separately in different areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenosquamous colon carcinoma

Professional guidelines

PubMed

Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984

Recent clinical studies

Etiology

Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Adeno-squamous and squamous cell carcinoma of the gallbladder: The importance of histology in surgical management.
Leigh N, Solomon D, Pletcher E, Sullivan B, Sarpel U, Labow DM, Magge DR, Golas BJ
Am J Surg 2020 Nov;220(5):1242-1248. Epub 2020 Jul 1 doi: 10.1016/j.amjsurg.2020.06.050. PMID: 32646581
Ratio between maximum standardized uptake value of N1 lymph nodes and tumor predicts N2 disease in patients with non-small cell lung cancer in 18F-FDG PET-CT scan.
Honguero Martínez AF, García Jiménez MD, García Vicente A, López-Torres Hidalgo J, Colon MJ, van Gómez López O, Soriano Castrejón ÁM, León Atance P
Rev Esp Med Nucl Imagen Mol 2016 May-Jun;35(3):159-64. Epub 2015 Oct 26 doi: 10.1016/j.remn.2015.08.004. PMID: 26514322
Unsuspected metastases presenting as solitary soft tissue lesions: a fourteen-year review.
Glockner JF, White LM, Sundaram M, McDonald DJ
Skeletal Radiol 2000 May;29(5):270-4. doi: 10.1007/s002560050606. PMID: 10883446
Carcinoma of the endometrium.
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Diagnosis

Colorectal Adenosquamous Carcinoma: Demographics, Tumor Characteristics, and Survival Benefits of Surgery with Chemoradiation.
Ullah A, Kenol GS, Lee KT, Yasinzai AQK, Wali A, Waheed A, Heneidi S, Ramamoorthy BU, Karki NR, Blakely AM
J Gastrointest Cancer 2024 Sep;55(3):1079-1088. Epub 2024 Apr 12 doi: 10.1007/s12029-024-01052-4. PMID: 38607504
Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Ratio between maximum standardized uptake value of N1 lymph nodes and tumor predicts N2 disease in patients with non-small cell lung cancer in 18F-FDG PET-CT scan.
Honguero Martínez AF, García Jiménez MD, García Vicente A, López-Torres Hidalgo J, Colon MJ, van Gómez López O, Soriano Castrejón ÁM, León Atance P
Rev Esp Med Nucl Imagen Mol 2016 May-Jun;35(3):159-64. Epub 2015 Oct 26 doi: 10.1016/j.remn.2015.08.004. PMID: 26514322
Unsuspected metastases presenting as solitary soft tissue lesions: a fourteen-year review.
Glockner JF, White LM, Sundaram M, McDonald DJ
Skeletal Radiol 2000 May;29(5):270-4. doi: 10.1007/s002560050606. PMID: 10883446
Carcinoma of the endometrium.
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Therapy

Application of colon interposition among the esophageal cancer patients with partial gastrectomy.
Chen Q, Mao W, Yu H, Liang Y, Wang J, Chen G
J Cancer Res Ther 2016 Dec;12(Supplement):C212-C216. doi: 10.4103/0973-1482.200602. PMID: 28230019
A phase I trial of irinotecan alternating with epirubicin in patients with advanced malignancies.
Goff LW, Rothenberg ML, Lockhart AC, Roth BJ, VerMeulen WL, Chan E, Berlin JD
Am J Clin Oncol 2008 Oct;31(5):413-6. doi: 10.1097/COC.0b013e318168ef2a. PMID: 18838875
Adenosquamous carcinoma of the rectum showing endocrine-cell differentiation: report of a case.
Kono T, Yamamoto Y, Kakisaka A, Tokusasi Y, Miyokawa N, Kasai S
Dis Colon Rectum 1999 Aug;42(8):1089-92. doi: 10.1007/BF02236710. PMID: 10458137
Squamous-cell carcinoma of the colon responsive to combination chemotherapy: report of two cases and review of the literature.
Juturi JV, Francis B, Koontz PW, Wilkes JD
Dis Colon Rectum 1999 Jan;42(1):102-9. doi: 10.1007/BF02235191. PMID: 10211528
Carcinoma of the endometrium.
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Prognosis

Colorectal Adenosquamous Carcinoma: Demographics, Tumor Characteristics, and Survival Benefits of Surgery with Chemoradiation.
Ullah A, Kenol GS, Lee KT, Yasinzai AQK, Wali A, Waheed A, Heneidi S, Ramamoorthy BU, Karki NR, Blakely AM
J Gastrointest Cancer 2024 Sep;55(3):1079-1088. Epub 2024 Apr 12 doi: 10.1007/s12029-024-01052-4. PMID: 38607504
Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study.
Cheng C, Luo Z, Xiong W, Shi Z, Tan H
Int J Colorectal Dis 2022 Jul;37(7):1581-1592. Epub 2022 Jun 9 doi: 10.1007/s00384-022-04198-4. PMID: 35678851
Ratio between maximum standardized uptake value of N1 lymph nodes and tumor predicts N2 disease in patients with non-small cell lung cancer in 18F-FDG PET-CT scan.
Honguero Martínez AF, García Jiménez MD, García Vicente A, López-Torres Hidalgo J, Colon MJ, van Gómez López O, Soriano Castrejón ÁM, León Atance P
Rev Esp Med Nucl Imagen Mol 2016 May-Jun;35(3):159-64. Epub 2015 Oct 26 doi: 10.1016/j.remn.2015.08.004. PMID: 26514322
Unsuspected metastases presenting as solitary soft tissue lesions: a fourteen-year review.
Glockner JF, White LM, Sundaram M, McDonald DJ
Skeletal Radiol 2000 May;29(5):270-4. doi: 10.1007/s002560050606. PMID: 10883446

Clinical prediction guides

Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study.
Cheng C, Luo Z, Xiong W, Shi Z, Tan H
Int J Colorectal Dis 2022 Jul;37(7):1581-1592. Epub 2022 Jun 9 doi: 10.1007/s00384-022-04198-4. PMID: 35678851
Adenosquamous carcinoma of the right colon with diffuse signet-ring mucinous component.
Di Prete M, Baciorri F, Franceschilli M, Bagaglini G, Sica G, Doldo E, Palmieri G, Orlandi A
Clin J Gastroenterol 2020 Aug;13(4):555-559. Epub 2020 Feb 5 doi: 10.1007/s12328-020-01101-y. PMID: 32026256
Ratio between maximum standardized uptake value of N1 lymph nodes and tumor predicts N2 disease in patients with non-small cell lung cancer in 18F-FDG PET-CT scan.
Honguero Martínez AF, García Jiménez MD, García Vicente A, López-Torres Hidalgo J, Colon MJ, van Gómez López O, Soriano Castrejón ÁM, León Atance P
Rev Esp Med Nucl Imagen Mol 2016 May-Jun;35(3):159-64. Epub 2015 Oct 26 doi: 10.1016/j.remn.2015.08.004. PMID: 26514322
Colorectal cancer: prognostic values.
Manxhuka-Kerliu S, Telaku S, Ahmetaj H, Baruti A, Loxha S, Kerliu A
Bosn J Basic Med Sci 2009 Feb;9(1):19-24. doi: 10.17305/bjbms.2009.2851. PMID: 19284390Free PMC Article
Squamous metaplasia in colorectal polyps.
Almagro UA, Pintar K, Zellmer RB
Cancer 1984 Jun 15;53(12):2679-82. doi: 10.1002/1097-0142(19840615)53:12<2679::aid-cncr2820531219>3.0.co;2-6. PMID: 6722726

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