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Colon small cell neuroendocrine carcinoma

MedGen UID:
232087
Concept ID:
C1333099
Neoplastic Process
Synonyms: colon Oat cell carcinoma; Colon Small Cell Carcinoma; colon small cell carcinoma; colon small cell neuroendocrine cancer; Colon Small Cell Neuroendocrine Carcinoma; colon small cell neuroendocrine carcinoma; colonic Oat cell carcinoma; Colonic Small Cell Carcinoma; colonic small cell carcinoma; Oat cell carcinoma of colon; Oat cell carcinoma of the colon; Oat cell colon carcinoma; Small Cell Carcinoma of Colon; small cell carcinoma of colon; Small Cell Carcinoma of the Colon; small cell carcinoma of the colon; Small Cell Colon Carcinoma; small cell colon carcinoma
 
Monarch Initiative: MONDO:0003978

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Shen H, Cao D, Zhang X
Curr Top Med Chem 2023;23(10):921-930. doi: 10.2174/1568026623666230504101208. PMID: 37150988
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874
Von Pawel J
Bull Cancer 2004 May 1;91(5):E70-6. PMID: 15582898

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Oster P, Vaillant L, Riva E, McMillan B, Begka C, Truntzer C, Richard C, Leblond MM, Messaoudene M, Machremi E, Limagne E, Ghiringhelli F, Routy B, Verdeil G, Velin D
Gut 2022 Mar;71(3):457-466. Epub 2021 Jul 12 doi: 10.1136/gutjnl-2020-323392. PMID: 34253574Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Wu YL, Cheng Y, Zhou X, Lee KH, Nakagawa K, Niho S, Tsuji F, Linke R, Rosell R, Corral J, Migliorino MR, Pluzanski A, Sbar EI, Wang T, White JL, Nadanaciva S, Sandin R, Mok TS
Lancet Oncol 2017 Nov;18(11):1454-1466. Epub 2017 Sep 25 doi: 10.1016/S1470-2045(17)30608-3. PMID: 28958502

Diagnosis

Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Zhu KJ, Lee PJ, Austin KKS, Solomon MJ
Dis Colon Rectum 2019 Feb;62(2):196-202. doi: 10.1097/DCR.0000000000001249. PMID: 30640835
Carter BW, Halpenny DF, Ginsberg MS, Papadimitrakopoulou VA, de Groot PM
J Thorac Imaging 2017 Sep;32(5):300-312. doi: 10.1097/RTI.0000000000000291. PMID: 28786858
Owen RW
IARC Sci Publ 2001;154:101-11. PMID: 11220650

Therapy

Roskoski R Jr
Pharmacol Res 2022 Jan;175:106037. Epub 2021 Dec 15 doi: 10.1016/j.phrs.2021.106037. PMID: 34921994
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Perez-Ruiz E, Minute L, Otano I, Alvarez M, Ochoa MC, Belsue V, de Andrea C, Rodriguez-Ruiz ME, Perez-Gracia JL, Marquez-Rodas I, Llacer C, Alvarez M, de Luque V, Molina C, Teijeira A, Berraondo P, Melero I
Nature 2019 May;569(7756):428-432. Epub 2019 May 1 doi: 10.1038/s41586-019-1162-y. PMID: 31043740
Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R
Science 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043. PMID: 28912244Free PMC Article

Prognosis

Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Kasajima A, Klöppel G
Pathol Int 2022 Oct;72(10):488-495. Epub 2022 Aug 19 doi: 10.1111/pin.13266. PMID: 35983917
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Wu YL, Cheng Y, Zhou X, Lee KH, Nakagawa K, Niho S, Tsuji F, Linke R, Rosell R, Corral J, Migliorino MR, Pluzanski A, Sbar EI, Wang T, White JL, Nadanaciva S, Sandin R, Mok TS
Lancet Oncol 2017 Nov;18(11):1454-1466. Epub 2017 Sep 25 doi: 10.1016/S1470-2045(17)30608-3. PMID: 28958502

Clinical prediction guides

Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Xia T, Zhang Z, Zhang X, Li Q
Cell Cycle 2022 Apr;21(7):741-753. Epub 2022 Mar 8 doi: 10.1080/15384101.2021.2023305. PMID: 35258413Free PMC Article
Oster P, Vaillant L, Riva E, McMillan B, Begka C, Truntzer C, Richard C, Leblond MM, Messaoudene M, Machremi E, Limagne E, Ghiringhelli F, Routy B, Verdeil G, Velin D
Gut 2022 Mar;71(3):457-466. Epub 2021 Jul 12 doi: 10.1136/gutjnl-2020-323392. PMID: 34253574Free PMC Article
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Delladetsima I, Sakellariou S, Govaere O, Poulaki E, Felekouras E, Tiniakos D
Histopathology 2018 May;72(6):1060-1065. Epub 2018 Feb 14 doi: 10.1111/his.13450. PMID: 29220096

Recent systematic reviews

Fassi E, Mandruzzato M, Zamparini M, Bianchi S, Petrelli F, Baggi A, Alberti A, Grisanti S, Berruti A
Lung Cancer 2023 May;179:107176. Epub 2023 Mar 22 doi: 10.1016/j.lungcan.2023.107176. PMID: 37015149
Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
Zhang H, Huang Z, Zou X, Liu T
Oncotarget 2016 Dec 13;7(50):82473-82481. doi: 10.18632/oncotarget.12666. PMID: 27756883Free PMC Article
Fiorino S, Bacchi-Reggiani L, de Biase D, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Acquaviva G, di Tommaso L, Bondi A, Visani M, Sabbatani S, Pontoriero L, Fabbri C, Cuppini A, Pession A, Jovine E
World J Gastroenterol 2015 Dec 7;21(45):12896-953. doi: 10.3748/wjg.v21.i45.12896. PMID: 26668515Free PMC Article
Linardou H, Dahabreh IJ, Kanaloupiti D, Siannis F, Bafaloukos D, Kosmidis P, Papadimitriou CA, Murray S
Lancet Oncol 2008 Oct;9(10):962-72. Epub 2008 Sep 17 doi: 10.1016/S1470-2045(08)70206-7. PMID: 18804418

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

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