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Esophageal Non-Hodgkin Lymphoma

MedGen UID:
232165
•Concept ID:
C1333464
•
Neoplastic Process
Synonyms: Esophageal Non-Hodgkin's Lymphoma; Esophagus Non-Hodgkin Lymphoma; Non-Hodgkin's Esophagus Lymphoma; Non-Hodgkin's Lymphoma of Esophagus; Non-Hodgkin's Lymphoma of the Esophagus; Primary Esophageal Non-Hodgkin's Lymphoma

Definition

An extranodal non-Hodgkin lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus. Dysphagia may be the presenting symptom. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.
Corso S, Cargnelutti M, Durando S, Menegon S, Apicella M, Migliore C, Capeloa T, Ughetto S, Isella C, Medico E, Bertotti A, Sassi F, Sarotto I, Casorzo L, Pisacane A, Mangioni M, Sottile A, Degiuli M, Fumagalli U, Sgroi G, Molfino S, De Manzoni G, Rosati R, De Simone M, Marrelli D, Saragoni L, Rausei S, Pallabazzer G, Roviello F, Cassoni P, Sapino A, Bass A, Giordano S
Neoplasia 2018 May;20(5):443-455. Epub 2018 Mar 23 doi: 10.1016/j.neo.2018.02.003. PMID: 29574251Free PMC Article
FDG-PET/CT based response-adapted treatment.
de Geus-Oei LF, Vriens D, Arens AI, Hutchings M, Oyen WJ
Cancer Imaging 2012 Sep 28;12(2):324-35. doi: 10.1102/1470-7330.2012.9006. PMID: 23023063Free PMC Article
Ascorbic acid in the prevention and treatment of cancer.
Head KA
Altern Med Rev 1998 Jun;3(3):174-86. PMID: 9630735

Recent clinical studies

Etiology

Zanidatamab, a novel bispecific antibody, for the treatment of locally advanced or metastatic HER2-expressing or HER2-amplified cancers: a phase 1, dose-escalation and expansion study.
Meric-Bernstam F, Beeram M, Hamilton E, Oh DY, Hanna DL, Kang YK, Elimova E, Chaves J, Goodwin R, Lee J, Nabell L, Rha SY, Mayordomo J, El-Khoueiry A, Pant S, Raghav K, Kim JW, Patnaik A, Gray T, Davies R, Ozog MA, Woolery J, Lee KW
Lancet Oncol 2022 Dec;23(12):1558-1570. Epub 2022 Nov 16 doi: 10.1016/S1470-2045(22)00621-0. PMID: 36400106
Red and processed meat consumption and cancer outcomes: Umbrella review.
Huang Y, Cao D, Chen Z, Chen B, Li J, Guo J, Dong Q, Liu L, Wei Q
Food Chem 2021 Sep 15;356:129697. Epub 2021 Mar 27 doi: 10.1016/j.foodchem.2021.129697. PMID: 33838606
Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis.
Soteriades ES, Kim J, Christophi CA, Kales SN
Asian Pac J Cancer Prev 2019 Nov 1;20(11):3221-3231. doi: 10.31557/APJCP.2019.20.11.3221. PMID: 31759344Free PMC Article
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, Fleming T, Forouzanfar MH, Hancock J, Hay RJ, Hunter-Merrill R, Huynh C, Hosgood HD, Johnson CO, Jonas JB, Khubchandani J, Kumar GA, Kutz M, Lan Q, Larson HJ, Liang X, Lim SS, Lopez AD, MacIntyre MF, Marczak L, Marquez N, Mokdad AH, Pinho C, Pourmalek F, Salomon JA, Sanabria JR, Sandar L, Sartorius B, Schwartz SM, Shackelford KA, Shibuya K, Stanaway J, Steiner C, Sun J, Takahashi K, Vollset SE, Vos T, Wagner JA, Wang H, Westerman R, Zeeb H, Zoeckler L, Abd-Allah F, Ahmed MB, Alabed S, Alam NK, Aldhahri SF, Alem G, Alemayohu MA, Ali R, Al-Raddadi R, Amare A, Amoako Y, Artaman A, Asayesh H, Atnafu N, Awasthi A, Saleem HB, Barac A, Bedi N, Bensenor I, Berhane A, Bernabé E, Betsu B, Binagwaho A, Boneya D, Campos-Nonato I, Castañeda-Orjuela C, Catalá-López F, Chiang P, Chibueze C, Chitheer A, Choi JY, Cowie B, Damtew S, das Neves J, Dey S, Dharmaratne S, Dhillon P, Ding E, Driscoll T, Ekwueme D, Endries AY, Farvid M, Farzadfar F, Fernandes J, Fischer F, G/Hiwot TT, Gebru A, Gopalani S, Hailu A, Horino M, Horita N, Husseini A, Huybrechts I, Inoue M, Islami F, Jakovljevic M, James S, Javanbakht M, Jee SH, Kasaeian A, Kedir MS, Khader YS, Khang YH, Kim D, Leigh J, Linn S, Lunevicius R, El Razek HMA, Malekzadeh R, Malta DC, Marcenes W, Markos D, Melaku YA, Meles KG, Mendoza W, Mengiste DT, Meretoja TJ, Miller TR, Mohammad KA, Mohammadi A, Mohammed S, Moradi-Lakeh M, Nagel G, Nand D, Le Nguyen Q, Nolte S, Ogbo FA, Oladimeji KE, Oren E, Pa M, Park EK, Pereira DM, Plass D, Qorbani M, Radfar A, Rafay A, Rahman M, Rana SM, Søreide K, Satpathy M, Sawhney M, Sepanlou SG, Shaikh MA, She J, Shiue I, Shore HR, Shrime MG, So S, Soneji S, Stathopoulou V, Stroumpoulis K, Sufiyan MB, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tessema GA, Thakur JS, Tran BX, Ukwaja KN, Uzochukwu BSC, Vlassov VV, Weiderpass E, Wubshet Terefe M, Yebyo HG, Yimam HH, Yonemoto N, Younis MZ, Yu C, Zaidi Z, Zaki MES, Zenebe ZM, Murray CJL, Naghavi M
JAMA Oncol 2017 Apr 1;3(4):524-548. doi: 10.1001/jamaoncol.2016.5688. PMID: 27918777Free PMC Article
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Diagnosis

Gender Differences in Obesity-Related Cancers.
Argyrakopoulou G, Dalamaga M, Spyrou N, Kokkinos A
Curr Obes Rep 2021 Jun;10(2):100-115. Epub 2021 Feb 1 doi: 10.1007/s13679-021-00426-0. PMID: 33523397
AIDS-associated Esophageal Plasmablastic Lymphoma.
Abdulla HM, Cohn S
Clin Gastroenterol Hepatol 2021 Jan;19(1):A18. Epub 2019 Dec 27 doi: 10.1016/j.cgh.2019.12.027. PMID: 31887446
Primary cardiac lymphoma.
Chia AXF, Zhao Z, Lim SL
BMJ Case Rep 2019 Dec 2;12(12) doi: 10.1136/bcr-2019-230468. PMID: 31796452Free PMC Article
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, Fleming T, Forouzanfar MH, Hancock J, Hay RJ, Hunter-Merrill R, Huynh C, Hosgood HD, Johnson CO, Jonas JB, Khubchandani J, Kumar GA, Kutz M, Lan Q, Larson HJ, Liang X, Lim SS, Lopez AD, MacIntyre MF, Marczak L, Marquez N, Mokdad AH, Pinho C, Pourmalek F, Salomon JA, Sanabria JR, Sandar L, Sartorius B, Schwartz SM, Shackelford KA, Shibuya K, Stanaway J, Steiner C, Sun J, Takahashi K, Vollset SE, Vos T, Wagner JA, Wang H, Westerman R, Zeeb H, Zoeckler L, Abd-Allah F, Ahmed MB, Alabed S, Alam NK, Aldhahri SF, Alem G, Alemayohu MA, Ali R, Al-Raddadi R, Amare A, Amoako Y, Artaman A, Asayesh H, Atnafu N, Awasthi A, Saleem HB, Barac A, Bedi N, Bensenor I, Berhane A, Bernabé E, Betsu B, Binagwaho A, Boneya D, Campos-Nonato I, Castañeda-Orjuela C, Catalá-López F, Chiang P, Chibueze C, Chitheer A, Choi JY, Cowie B, Damtew S, das Neves J, Dey S, Dharmaratne S, Dhillon P, Ding E, Driscoll T, Ekwueme D, Endries AY, Farvid M, Farzadfar F, Fernandes J, Fischer F, G/Hiwot TT, Gebru A, Gopalani S, Hailu A, Horino M, Horita N, Husseini A, Huybrechts I, Inoue M, Islami F, Jakovljevic M, James S, Javanbakht M, Jee SH, Kasaeian A, Kedir MS, Khader YS, Khang YH, Kim D, Leigh J, Linn S, Lunevicius R, El Razek HMA, Malekzadeh R, Malta DC, Marcenes W, Markos D, Melaku YA, Meles KG, Mendoza W, Mengiste DT, Meretoja TJ, Miller TR, Mohammad KA, Mohammadi A, Mohammed S, Moradi-Lakeh M, Nagel G, Nand D, Le Nguyen Q, Nolte S, Ogbo FA, Oladimeji KE, Oren E, Pa M, Park EK, Pereira DM, Plass D, Qorbani M, Radfar A, Rafay A, Rahman M, Rana SM, Søreide K, Satpathy M, Sawhney M, Sepanlou SG, Shaikh MA, She J, Shiue I, Shore HR, Shrime MG, So S, Soneji S, Stathopoulou V, Stroumpoulis K, Sufiyan MB, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tessema GA, Thakur JS, Tran BX, Ukwaja KN, Uzochukwu BSC, Vlassov VV, Weiderpass E, Wubshet Terefe M, Yebyo HG, Yimam HH, Yonemoto N, Younis MZ, Yu C, Zaidi Z, Zaki MES, Zenebe ZM, Murray CJL, Naghavi M
JAMA Oncol 2017 Apr 1;3(4):524-548. doi: 10.1001/jamaoncol.2016.5688. PMID: 27918777Free PMC Article
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373

Therapy

Zanidatamab, a novel bispecific antibody, for the treatment of locally advanced or metastatic HER2-expressing or HER2-amplified cancers: a phase 1, dose-escalation and expansion study.
Meric-Bernstam F, Beeram M, Hamilton E, Oh DY, Hanna DL, Kang YK, Elimova E, Chaves J, Goodwin R, Lee J, Nabell L, Rha SY, Mayordomo J, El-Khoueiry A, Pant S, Raghav K, Kim JW, Patnaik A, Gray T, Davies R, Ozog MA, Woolery J, Lee KW
Lancet Oncol 2022 Dec;23(12):1558-1570. Epub 2022 Nov 16 doi: 10.1016/S1470-2045(22)00621-0. PMID: 36400106
Sugemalimab: First Approval.
Dhillon S, Duggan S
Drugs 2022 Apr;82(5):593-599. doi: 10.1007/s40265-022-01693-4. PMID: 35298827
Red and processed meat consumption and cancer outcomes: Umbrella review.
Huang Y, Cao D, Chen Z, Chen B, Li J, Guo J, Dong Q, Liu L, Wei Q
Food Chem 2021 Sep 15;356:129697. Epub 2021 Mar 27 doi: 10.1016/j.foodchem.2021.129697. PMID: 33838606
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Prognosis

Gender Differences in Obesity-Related Cancers.
Argyrakopoulou G, Dalamaga M, Spyrou N, Kokkinos A
Curr Obes Rep 2021 Jun;10(2):100-115. Epub 2021 Feb 1 doi: 10.1007/s13679-021-00426-0. PMID: 33523397
Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis.
Soteriades ES, Kim J, Christophi CA, Kales SN
Asian Pac J Cancer Prev 2019 Nov 1;20(11):3221-3231. doi: 10.31557/APJCP.2019.20.11.3221. PMID: 31759344Free PMC Article
A good start of immunotherapy in esophageal cancer.
Zhao Q, Yu J, Meng X
Cancer Med 2019 Aug;8(10):4519-4526. Epub 2019 Jun 23 doi: 10.1002/cam4.2336. PMID: 31231980Free PMC Article
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, Fleming T, Forouzanfar MH, Hancock J, Hay RJ, Hunter-Merrill R, Huynh C, Hosgood HD, Johnson CO, Jonas JB, Khubchandani J, Kumar GA, Kutz M, Lan Q, Larson HJ, Liang X, Lim SS, Lopez AD, MacIntyre MF, Marczak L, Marquez N, Mokdad AH, Pinho C, Pourmalek F, Salomon JA, Sanabria JR, Sandar L, Sartorius B, Schwartz SM, Shackelford KA, Shibuya K, Stanaway J, Steiner C, Sun J, Takahashi K, Vollset SE, Vos T, Wagner JA, Wang H, Westerman R, Zeeb H, Zoeckler L, Abd-Allah F, Ahmed MB, Alabed S, Alam NK, Aldhahri SF, Alem G, Alemayohu MA, Ali R, Al-Raddadi R, Amare A, Amoako Y, Artaman A, Asayesh H, Atnafu N, Awasthi A, Saleem HB, Barac A, Bedi N, Bensenor I, Berhane A, Bernabé E, Betsu B, Binagwaho A, Boneya D, Campos-Nonato I, Castañeda-Orjuela C, Catalá-López F, Chiang P, Chibueze C, Chitheer A, Choi JY, Cowie B, Damtew S, das Neves J, Dey S, Dharmaratne S, Dhillon P, Ding E, Driscoll T, Ekwueme D, Endries AY, Farvid M, Farzadfar F, Fernandes J, Fischer F, G/Hiwot TT, Gebru A, Gopalani S, Hailu A, Horino M, Horita N, Husseini A, Huybrechts I, Inoue M, Islami F, Jakovljevic M, James S, Javanbakht M, Jee SH, Kasaeian A, Kedir MS, Khader YS, Khang YH, Kim D, Leigh J, Linn S, Lunevicius R, El Razek HMA, Malekzadeh R, Malta DC, Marcenes W, Markos D, Melaku YA, Meles KG, Mendoza W, Mengiste DT, Meretoja TJ, Miller TR, Mohammad KA, Mohammadi A, Mohammed S, Moradi-Lakeh M, Nagel G, Nand D, Le Nguyen Q, Nolte S, Ogbo FA, Oladimeji KE, Oren E, Pa M, Park EK, Pereira DM, Plass D, Qorbani M, Radfar A, Rafay A, Rahman M, Rana SM, Søreide K, Satpathy M, Sawhney M, Sepanlou SG, Shaikh MA, She J, Shiue I, Shore HR, Shrime MG, So S, Soneji S, Stathopoulou V, Stroumpoulis K, Sufiyan MB, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tessema GA, Thakur JS, Tran BX, Ukwaja KN, Uzochukwu BSC, Vlassov VV, Weiderpass E, Wubshet Terefe M, Yebyo HG, Yimam HH, Yonemoto N, Younis MZ, Yu C, Zaidi Z, Zaki MES, Zenebe ZM, Murray CJL, Naghavi M
JAMA Oncol 2017 Apr 1;3(4):524-548. doi: 10.1001/jamaoncol.2016.5688. PMID: 27918777Free PMC Article
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373

Clinical prediction guides

Incidence of cancer (other than gastric cancer) in pernicious anaemia: A systematic review with meta-analysis.
Lahner E, Capasso M, Carabotti M, Annibale B
Dig Liver Dis 2018 Aug;50(8):780-786. Epub 2018 May 24 doi: 10.1016/j.dld.2018.05.012. PMID: 29887343
Association between the ERCC2 Asp312Asn polymorphism and risk of cancer.
Xiao F, Pu J, Wen Q, Huang Q, Zhang Q, Huang B, Huang S, Lan A, Zhang Y, Li J, Zhao D, Shen J, Wu H, He Y, Li H, Yang X
Oncotarget 2017 Jul 18;8(29):48488-48506. doi: 10.18632/oncotarget.17290. PMID: 28489582Free PMC Article
Antiviral therapy: why does it fail in HCV-related chronic hepatitis?
Masarone M, Persico M
Expert Rev Anti Infect Ther 2011 May;9(5):535-43. doi: 10.1586/eri.11.10. PMID: 21609265
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327
Hepatic and renal toxicities associated with perchloroethylene.
Lash LH, Parker JC
Pharmacol Rev 2001 Jun;53(2):177-208. PMID: 11356983

Recent systematic reviews

Primary esophageal non-Hodgkin's lymphoma: demographics, clinical characteristics, histopathologic types, and survival in 179 patients from the SEER program and systematic review of the literature.
Quiroga-Centeno AC, Bautista-Parada IR, Tapias LF, Gómez-Ochoa SA
Esophagus 2021 Oct;18(4):734-742. Epub 2021 Apr 20 doi: 10.1007/s10388-021-00842-0. PMID: 33880688
Vitamin D Receptor Polymorphisms and Cancer.
Gnagnarella P, Raimondi S, Aristarco V, Johansson HA, Bellerba F, Corso F, Gandini S
Adv Exp Med Biol 2020;1268:53-114. doi: 10.1007/978-3-030-46227-7_4. PMID: 32918214
A systematic review of epidemiologic studies of styrene and cancer.
Collins JJ, Delzell E
Crit Rev Toxicol 2018 Jul;48(6):443-470. Epub 2018 Mar 28 doi: 10.1080/10408444.2018.1445700. PMID: 29589466
Eradication of Helicobacter pylori and Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies.
Doorakkers E, Lagergren J, Engstrand L, Brusselaers N
J Natl Cancer Inst 2016 Sep;108(9) Epub 2016 Jul 14 doi: 10.1093/jnci/djw132. PMID: 27416750
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

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