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Grade 2 Rectal Adenocarcinoma

MedGen UID:
232567
Concept ID:
C1333865
Neoplastic Process
Synonyms: Grade II Rectal Adenocarcinoma; Moderately Differentiated Rectal Adenocarcinoma

Definition

A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Rectal Adenocarcinoma

Professional guidelines

PubMed

Graure G, Preda D, Cartu D, Margaritescu D, Ramboiu S, Bica M, Patrascu AM, Cazacu S, Turcu A, Radu R, Patrascu S, Matei M, Surlin V
Chirurgia (Bucur) 2023 Oct;118(5):513-524. doi: 10.21614/chirurgia.2023.v.118.i.5.p.513. PMID: 37965835
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Chin RI, Roy A, Pedersen KS, Huang Y, Hunt SR, Glasgow SC, Tan BR, Wise PE, Silviera ML, Smith RK, Suresh R, Badiyan SN, Shetty AS, Henke LE, Mutch MG, Kim H
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):715-725. Epub 2021 Oct 12 doi: 10.1016/j.ijrobp.2021.10.004. PMID: 34653579

Recent clinical studies

Etiology

Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Goedegebuure RSA, Harrasser M, de Klerk LK, van Schooten TS, van Grieken NCT, Eken M, Grifhorst MS, Pocorni N, Jordanova ES, van Berge Henegouwen MI, Pouw RE, Verheul HMW, van der Vliet JJ, van Laarhoven HWM, Thijssen VLJL, Bass AJ, De Gruijl TD, Derks S
Oncoimmunology 2021;10(1):1954807. Epub 2021 Aug 4 doi: 10.1080/2162402X.2021.1954807. PMID: 34377591Free PMC Article
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Petrillo A, Fusco R, Petrillo M, Granata V, Sansone M, Avallone A, Delrio P, Pecori B, Tatangelo F, Ciliberto G
Eur Radiol 2015 Jul;25(7):1935-45. Epub 2015 Jan 11 doi: 10.1007/s00330-014-3581-3. PMID: 25577525
Stipa S, Nicolanti V, Botti C, Cosimelli M, Mannella E, Stipa F, Giannarelli D, Bangrazi C, Cavaliere R
J Surg Oncol Suppl 1991;2:155-60. doi: 10.1002/jso.2930480532. PMID: 1892525

Diagnosis

Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr
N Engl J Med 2022 Jun 23;386(25):2363-2376. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2201445. PMID: 35660797Free PMC Article
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Lamfichekh N, Juzyna B, Jouffroy-Zeller C, Rullier E, Marchal F, Gourgou S, Castan F, Borg C; Unicancer Gastrointestinal Group and Partenariat de Recherche en Oncologie Digestive (PRODIGE) Group
Lancet Oncol 2021 May;22(5):702-715. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00079-6. PMID: 33862000
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740

Therapy

Thompson HM, Omer DM, Lin S, Kim JK, Yuval JB, Verheij FS, Qin LX, Gollub MJ, Wu AJ, Lee M, Patil S, Hezel AF, Marcet JE, Cataldo PA, Polite BN, Herzig DO, Liska D, Oommen S, Friel CM, Ternent CA, Coveler AL, Hunt SR, Garcia-Aguilar J; OPRA Consortium
JAMA Netw Open 2024 Jan 2;7(1):e2350903. doi: 10.1001/jamanetworkopen.2023.50903. PMID: 38194231Free PMC Article
Gerard JP, Barbet N, Schiappa R, Magné N, Martel I, Mineur L, Deberne M, Zilli T, Dhadda A, Myint AS; ICONE group
Lancet Gastroenterol Hepatol 2023 Apr;8(4):356-367. Epub 2023 Feb 16 doi: 10.1016/S2468-1253(22)00392-2. PMID: 36801007
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Lamfichekh N, Juzyna B, Jouffroy-Zeller C, Rullier E, Marchal F, Gourgou S, Castan F, Borg C; Unicancer Gastrointestinal Group and Partenariat de Recherche en Oncologie Digestive (PRODIGE) Group
Lancet Oncol 2021 May;22(5):702-715. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00079-6. PMID: 33862000
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740

Prognosis

Lin ZY, Zhang P, Chi P, Xiao Y, Xu XM, Zhang AM, Qiu XF, Wu JX, Yuan Y, Wang ZN, Qu XJ, Li X, Nie X, Yang M, Cai KL, Zhang WK, Huang Y, Sun Z, Hou ZG, Ma C, Cheng FZ, Tao KX, Zhang T
Ann Oncol 2024 Oct;35(10):882-891. Epub 2024 Jul 2 doi: 10.1016/j.annonc.2024.06.015. PMID: 38964714
Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Wilson JW, Nostro MC, Balzi M, Faraoni P, Cianchi F, Becciolini A, Potten CS
Br J Cancer 2000 Jan;82(1):178-85. doi: 10.1054/bjoc.1999.0897. PMID: 10638987Free PMC Article
Halvorsen TB, Seim E
J Clin Pathol 1989 Feb;42(2):162-6. doi: 10.1136/jcp.42.2.162. PMID: 2921357Free PMC Article
Newland RC, Chapuis PH, Pheils MT, MacPherson JG
Cancer 1981 Mar 15;47(6):1424-9. doi: 10.1002/1097-0142(19810315)47:6<1424::aid-cncr2820470630>3.0.co;2-o. PMID: 7226068

Clinical prediction guides

Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Kirste S, Jacobasch L, Allgäuer M, Flentje M, Germer CT, Grützmann R, Hildebrandt G, Schwarzbach M, Bechstein WO, Sülberg H, Friede T, Gaedcke J, Ghadimi M, Hofheinz RD, Rödel C; German Rectal Cancer Study Group
JAMA Oncol 2022 Jan 1;8(1):e215445. Epub 2022 Jan 20 doi: 10.1001/jamaoncol.2021.5445. PMID: 34792531Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article
Petrillo A, Fusco R, Petrillo M, Granata V, Sansone M, Avallone A, Delrio P, Pecori B, Tatangelo F, Ciliberto G
Eur Radiol 2015 Jul;25(7):1935-45. Epub 2015 Jan 11 doi: 10.1007/s00330-014-3581-3. PMID: 25577525

Recent systematic reviews

Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038
Peng J, Lv J, Peng J
Int J Colorectal Dis 2021 Aug;36(8):1781-1790. Epub 2021 Mar 24 doi: 10.1007/s00384-021-03911-z. PMID: 33760952
Sajid MS, Farag S, Leung P, Sains P, Miles WF, Baig MK
Colorectal Dis 2014 Jan;16(1):2-14. doi: 10.1111/codi.12474. PMID: 24330432
Ranpura V, Hapani S, Chuang J, Wu S
Acta Oncol 2010 Apr;49(3):287-97. doi: 10.3109/02841860903524396. PMID: 20156114

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